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MMP9 — RELA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Kumar et al., FEBS Lett 1999
:
These results suggest that HIV-tat
induces MMP-9 in human monocytes through activation of PTPase and
NF-kappaB
Ricca et al., Int J Cancer 2000
(Breast Neoplasms) :
bcl-2 over-expression enhances
NF-kappaB activity and
induces mmp-9 transcription in human MCF7 ( ADR ) breast-cancer cells
Mengshol et al., Arthritis Rheum 2000
(MAP Kinase Signaling System) :
In chondrosarcoma cells,
MMP-1 induction depends on p38 and MEK ( an MAPK kinase of the extracellular signal regulated kinase pathway ) and does not
require JNK or
NF-kappaB
Azuma et al., Arthritis Rheum 2000
:
Because
matrix metalloproteinase 9 (MMP-9) is
regulated by nuclear factor kappaB
(NF-kappaB) , we investigated the effect of a super-repressor form of inhibitor of nuclear factor kappaBalpha ( srIkappaBalpha ) on the suppression of TNFalpha induced MMP-9 production in acinar cells
Hozumi et al., Am J Physiol Lung Cell Mol Physiol 2001
(Pneumonia) :
In this study, we determined whether the proinflammatory cytokines tumor necrosis factor (TNF)-alpha and interleukin-1 beta contribute to the regulation of matrix metalloproteinase (MMP)-9 in human bronchial epithelial cells and whether the induction of
MMP-9 is
regulated by the transcription factor
nuclear factor (NF)-kappa B
Yoo et al., Biochem Biophys Res Commun 2002
:
Electrophoretic mobility shift assay and site directed mutagenesis study on the consensus binding site for NF-kappaB revealed that the activation of
NF-kappaB is
required for the IL-1beta induced activation of
MMP-9 promoter
Hah et al., Biochem Biophys Res Commun 2003
(Carcinoma, Hepatocellular...) :
An absolute
role of the PKC dependent
NF-kappaB activation for induction of
MMP-9 in hepatocellular carcinoma cells
Woo et al., Cancer Res 2003
(Neoplasm Invasiveness) :
These data demonstrate a
role for
NF kappa B in the regulation of
MMP-9 expression and the ability of dykellic acid to suppress this action of NF kappa B
Takahra et al., Int J Biochem Cell Biol 2004
:
Induction of myofibroblast
MMP-9 transcription in three-dimensional collagen I gel cultures : regulation by
NF-kappaB , AP-1 and Sp1
Yamanaka et al., Clin Cancer Res 2004
(Neoplasm Invasiveness...) :
In vivo expression of IL-1beta and
MMP-9 and
activation of
NF-kappaB in 10 surgically resected gastric carcinoma specimens were examined immunohistochemically ... A
NF-kappaB inhibitor, pyrrolidine dithiocarbamate,
suppressed both
MMP-9 expression and invasiveness of IL-1beta treated GCTM-1 cells
Kim et al., Circ J 2004
(Carotid Stenosis) :
TWEAK induced activation of
MMP-9 was
mediated by activation of
NF-kappaB
Shukla et al., Neoplasia (New York, N.Y.) 2004
(Adenocarcinoma...) :
The nuclear levels of NF-kappaB/p65 correlated with concurrent increase in cytosolic levels of IkappaBalpha along with
NF-kappaB dependent expression of Bcl2, cyclin D1,
MMP-9 , and VEGF ... The nuclear levels of NF-kappaB/p65 correlated with concurrent increase in cytosolic levels of IkappaBalpha along with
NF-kappaB dependent expression of Bcl2, cyclin D1,
MMP-9 , and VEGF
Xie et al., J Biol Chem 2004
:
These observations suggest that 1 ) activation of ERK1/2 and JNKs plays a critical role in the regulation of MMP-9, not MMP-2, expression and activity ; 2 ) PKC-alpha/beta1 act upstream of JNKs, not ERK1/2 ; 3 ) PKC-zeta and -theta, not PKC-epsilon, act upstream of JNKs, ERK1/2, and NF-kappaB ; and 4 ) activation of
NF-kappaB stimulates expression and activity of
MMP-2 and -9
Sousa et al., FASEB J 2005
(Amyloid Neuropathies, Familial) :
Biglycan, NGAL, and
MMP-9 are transcriptionally
up-regulated by
NF-kappaB , a transcription factor that is activated in FAP nerves and SG
Kato et al., J Biol Chem 2005
(Melanoma, Experimental) :
These data suggest that PLD, mitogen activated protein kinases ( extracellular signal regulated kinases 1/2 and p38 ), and
NF kappa B mediate the acidic pHe signaling to
induce MMP-9 expression
Lu et al., J Leukoc Biol 2005
:
The
role of
NF-kappaB in regulation of
MMP-9 was demonstrated further by the inhibition of MMP-9 production by proteasome inhibitors, lactacystin and MG-132, which prevented the ubiquitination and dissociation of IkappaB from NF-kappaB
Dai et al., Ann Rheum Dis 2005
(Arthritis...) :
In chondrocytes responding to IL18, IL18 ( 1-100 ng/ml ) slightly increased the production of MMP-1,
MMP-3 , and MMP-13, which was
blocked by
NF-kappaB inhibitor and p38 mitogen activated protein kinase inhibitor
Parodi et al., J Vasc Surg 2005
(Aortic Aneurysm, Abdominal...) :
MMP-9 is one of the enzymes involved in aneurysm disease, and its production may be
induced in part by activation of the transcription factor
NF-kappaB
Ko et al., FEBS Lett 2005
:
PAF increased mRNA expression, protein synthesis, and
MMP-9 activity in ECV304 cells, in a
NF-kappaB dependent manner ... These data indicate that
NF-kappaB dependent
MMP-9 plays a key role in PAF induced angiogenesis
Wu et al., World J Gastroenterol 2005
(Helicobacter Infections...) :
These effects appear to be mediated through a NF-kappaB and COX-2 mediated pathway, as COX-2 or
NF-kappaB inhibitor significantly
attenuate the invasiveness of gastric cancer cells and the expressions of
MMP-9 and VEGF protein
Ho et al., Ann N Y Acad Sci 2005
:
In conclusion, these data suggest that relaxin induced
MMP-9 expression in THP-1 cells
involves NF-kappaB activation
Koh et al., Toxicology 2005
(Brain Ischemia...) :
Plasma MMP-9 increased maximally at 4h and then decreased rapidly, brain
MMP-9 increased maximally at 24 h and persisted until 72 h, and
NF-kappaB increased maximally at 24h and then decreased slowly in both groups
Lee et al., Virology 2005
:
Moreover,
NF-kappaB dependent expression of matrix metalloproteinase (MMP)-2 and
MMP-9 was observed in PRRSV infected cells, an observation which implies that NF-kappaB activation is a biologically significant aspect of PRRSV pathogenesis
Matsuyama et al., Am J Respir Cell Mol Biol 2005
(Sarcoidosis, Pulmonary) :
The inhibitor of
NF-kappaB inhibited the production of MCP-1 and
MMP-9
Ko et al., FEBS Lett 2005
:
Recently, we reported that PAF upregulates
MMP-9 expression in a
NF-kappaB dependent manner ... Our results suggest that PAF induced
MMP-9 expression, in a
NF-kappaB dependent manner, is regulated by Ca ( 2+ ), PI3K and ERK signaling pathways
Zhang et al., Pancreas 2006
(Neoplasm Invasiveness...) :
Subsequently, the EGF induced
MMP-9 and uPA expression and MMP-9 activity, as well as cell invasiveness, were also
inhibited by these
NF-kappaB inhibitors
Kim et al., FEBS Lett 2006
:
In summary, hirsutenone
inhibits the TPA induced upregulation of COX-2 and
MMP-9 in human breast epithelial cells, possibly by targeting
NF-kappaB , which may contribute to its chemopreventive effects
Yoshida et al., Respirology 2006
(Pulmonary Emphysema) :
A specific inhibitor of
NF-kappaB reduced
MMP production by alveolar macrophages from SP-D-/- mice
Fan et al., Rheumatol Int 2006
:
Role of mitogen activated protein kinases and
NFkappaB on IL-1beta induced effects on collagen type II,
MMP-1 and 13 mRNA expression in normal articular human chondrocytes
Chandrasekar et al., J Biol Chem 2006
(Atherosclerosis) :
IL-18 treatment increased both mRNA and protein expression of
MMP9 in human coronary artery SMCs. Gel shift, enzyme linked immunosorbent, and chromatin immunoprecipitation assays revealed a strong induction of IL-18 mediated AP-1 ( c-Fos, c-Jun, and Fra-1 ) and
NF-kappaB ( p50 and p65 )
activation and stimulation of MMP9 promoter dependent reporter gene activity in an AP-1- and NF-kappaB dependent manner
Rangaswami et al., Glycoconj J 2006
(Melanoma) :
Taken together, NIK acts as crucial regulator in OPN induced MAPK/IKK mediated
NF-kappaB dependent uPA secretion and
MMP-9 activation thereby controlling melanoma cell motility and chemoinvasion
Nguyen et al., Immunol Lett 2006
:
In this study, we investigated the intracellular signaling pathways underlying
TNF-alpha/NF-kappaB dependent expression of
MMP-9 in monocytes using chemical inhibitors that specifically inhibit distinct kinase pathways
Rhee et al., Mol Immunol 2007
:
These results lead us to a conclusion that
NF-kappaB activation is
required for
MMP-9 gene expression ... In summary, our data suggest that
NF-kappaB dependent expression of
MMP-9 in response to CpG-ODN plays an important role in the recruitment of immune cells
Lee et al., Biochem Biophys Res Commun 2006
(MAP Kinase Signaling System) :
Reporter gene, electrophoretic mobility shift, and Western blotting assays showed that wogonin
inhibits MMP-9 gene transcriptional activity by blocking the activation of
NF-kappaB via MAPK signaling pathways
Kim et al., Immunology 2006
(Atherosclerosis...) :
Stimulation of GITR caused
nuclear factor (NF)-kappaB dependent
activation of
matrix metalloproteinase-9 (MMP-9) and pro-inflammatory cytokine expression in both the human and mouse monocytic/macrophage cell lines, THP-1 and RAW264.7, respectively
Sun et al., Biochem Biophys Res Commun 2007
(Mechanotransduction, Cellular) :
Involvement of integrins, MAPK, and
NF-kappaB in regulation of the shear stress
induced MMP-9 expression in endothelial cells ... Inhibition of
NF-kappaB resulted in remarkable downregulation of stress induced
MMP-9 expression ... Our findings demonstrated that the shear stress induced
MMP-9 expression
involved integrins-p38 MAPK or
ERK1/2-NF-kappaB signaling pathways
Fukuyama et al., Mol Carcinog 2007
(Colorectal Neoplasms) :
However, it is not fully understood to what extent
NFkappaB contributes to induction of the metastasis associated
matrix metalloprotease-9 (MMP-9) gene and sensitivity to the commonly used chemotherapeutic 5-fluorouracil ( 5-Fu ) in CRC ...
NFkappaB plays a predominant role in
MMP-9 gene induction in RKO cells, as evidenced by the failure of tumor necrosis factor alpha (TNFalpha) to induce MMP-9 in either of the NFkappaB signaling mutants ... Our results suggest that TNFalpha dependent induction of
MMP-9 gene expression is tightly
regulated by oscillatory/cumulative activation of
NFkappaB and that 5-Fu stimulates NFkappaB and RKO CRC cell survival through induction of IKK activity
Doller et al., J Am Soc Nephrol 2007
(Disease Progression...) :
It is interesting that only the JNK inhibitor SP600125 impaired the cytokine triggered MMP-9 level, suggesting that CsA, via inhibition of the JNK pathway, negatively interferes with the
NF-kappaB dependent transcriptional control of
MMP-9
Duxbury et al., Biochem Biophys Res Commun 2007
(Adenocarcinoma...) :
RRM2 induces
NF-kappaB dependent
MMP-9 activation and enhances cellular invasiveness ... RRM2 overexpression increases pancreatic adenocarcinoma cellular invasiveness and
MMP-9 expression in a
NF-kappaB dependent manner
Rhee et al., J Biochem Mol Biol 2007
:
Chromatin immunoprecipitation ( ChIP ) assays showed that functional interaction between
NF-kappaB and the MMP-9 promoter element is
necessary for LPS activated
MMP-9 induction in RAW 264.7 cells ... In conclusion, our observations demonstrate that
NF-kappaB contributes to LPS induced
MMP-9 gene expression in a mouse macrophage cell line
Bachmeier et al., Cell Physiol Biochem 2007
(Breast Neoplasms...) :
68 % of Curcumin treated but only 17 % of untreated animals showed no or very few lung metastases, most likely as a consequence of down-regulation of
NFkappa B/AP-1 dependent
MMP expression and direct apoptotic effects on circulating tumor cells but not on established metastases
Liang et al., J Cell Physiol 2007
(MAP Kinase Signaling System) :
Finally, the reporter gene assay revealed that MAPKs and
NF-kappaB are
required for IL-1beta induced
MMP-9 luciferase activity in HTSMCs. MMP-9 promoter activity was enhanced by IL-1beta in HTSMCs transfected with MMP-9-Luc, which was inhibited by helenalin, U0126, SB202190, and SP600125
Hsu et al., Food Chem Toxicol 2007
(Carcinoma, Hepatocellular...) :
Furthermore, EAC also inhibited the TNF-alpha activated
NF-kappaB dependent reporter gene expression of
MMP-9 and VEGF, and the invasion of cancer cells
Caruso et al., J Immunol 2007
(Gastritis...) :
Analysis of signaling pathways leading to MMP production reveals that IL-21 enhances NF-kappaB but not MAPK activation, and inhibition of
NF-kappaB activation
reduces IL-21 induced MMP-2 and
MMP-9 production
Jin et al., Mol Cancer Res 2007
(Neoplasm Invasiveness...) :
SN50, a specific inhibitor of
NF-kappaB , which could inhibit in vitro invasive and migratory abilities of gastric cancer cells,
reduced expression of uPA and
MMP9 proteins and increased expression of TIMP1 protein
Lee et al., Cardiovasc Res 2007
:
Down-regulation of NQO1
inhibits MMP-9 gene expression by suppressing activation of
nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1), well-known key elements mediating MMP-9 gene expression in its promoter, via the p38 MAPK and JNK pathways
Xue et al., Arthritis Rheum 2007
(Arthritis, Rheumatoid...) :
Furthermore, APC directly suppressed the production of tumor necrosis factor (TNF) and the activation of NF-kappaB and MAP kinase p38, and inhibitors of NF-kappaB or p38 reduced the production of MMP-9, suggesting that APC
inhibits MMP-9 by blocking TNF,
NF-kappaB , and p38
Safina et al., Oncogene 2008
(Lung Neoplasms...) :
TAK1 mediated regulation of
MMP-9 involves
NF-kappaB signaling ... Dn-TAK1 reduces NF-kappaB transcriptional response and inhibition of
NF-kappaB reduces expression of
MMP-9 and activity of the MMP-9 promoter reporter
Srivastava et al., J Biol Chem 2007
:
Overexpression of a dominant negative inhibitor of
NF-kappaB or AP-1
blocked the TNF-alpha induced expression of
MMP-9 in myotubes ... Furthermore, overexpression of a dominant negative mutant of TAK1 blocked the TNF-alpha induced expression of
MMP-9 and
activation of
NF-kappaB and AP-1
Bogatkevich et al., Arthritis Rheum 2007
(MAP Kinase Signaling System...) :
Inhibition of
MMP activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not
prevent HGF induced ERK-1/2 phosphorylation and
NF-kappaB activity, but significantly restored HGF inhibited collagen and CTGF accumulation
Yu et al., Biomed Pharmacother 2008
(Carcinoma, Hepatocellular...) :
NF-kappa B inhibitor
induced a marked reduction in
MMP-9 expression, and it suggested that NF-kappa B could play an important role in TNF-alpha mediated MMP-9 expression
Lee et al., Biochem Biophys Res Commun 2008
(MAP Kinase Signaling System...) :
Suppression of PMA induced tumor cell invasion by capillarisin via the inhibition of
NF-kappaB dependent
MMP-9 expression ... Capillarisin has been found to suppress PMA induced MMP-9 expression through inhibition of the
NF-kappaB dependent transcriptional activity of
MMP-9 gene via p38 MAPK and JNK signaling pathways ... These results suggest that capillarisin represents a potential anti-metastatic agent suppressing cancer cell invasion through specific inhibition of
NF-kappaB dependent
MMP-9 gene expression
Liao et al., Leuk Res 2008
:
In addition, the
NF-kappaB inhibitors ( pyrrolidinedithiocarbamate, BAY-11-7082 and lactacystin )
suppress the TPA induced
MMP-9 enzyme activity
Adya et al., Diabetes Care 2008
(Diabetes Mellitus, Type 2...) :
Visfatin induced
NF-kappaB signaling in human endothelial cells
affects the activation of gelatinases
MMP-2 and -9 , suggesting an important role of visfatin in the pathogenesis of vascular inflammation in obesity and type 2 diabetes
Ohno et al., Oral Microbiol Immunol 2008
(Inflammation) :
The
NF-kappaB inhibitor
suppressed the expression of CCL5 and
MMP9 , but not that of CXCL10, whereas P. gingivalis infection induced significant CCL5 expression in MyD88 ( -/- ) osteoblasts
Yu et al., Br J Nutr 2008
(Atherosclerosis) :
In this study, we investigated the effects of CA on TNF-alpha induced cell migration, the formation of intracellular reactive oxygen species, the translocation of
NF-kappaB and the
activation and expression of
MMP-9 in human aortic smooth muscle cells ( HASMC )
Lin et al., Toxicol Appl Pharmacol 2008
:
Furthermore, the
involvement of
NF-kappaB in TNF-alpha induced
MMP-9 production was consistent with that TNF-alpha stimulated degradation of IkappaB-alpha and translocation of NF-kappaB into the nucleus which were blocked by helenalin, but not by U0126 and SP600125, revealed by immunofluorescence staining ... The
regulation of
MMP-9 gene transcription by MAPKs and
NF-kappaB was further confirmed by gene luciferase activity assay
Tai et al., Oncogene 2008
(MAP Kinase Signaling System...) :
Axl promotes cell invasion by
inducing MMP-9 activity through activation of
NF-kappaB and Brg-1
Kim et al., Biochem Biophys Res Commun 2008
(Astrocytoma) :
The specific MEK inhibitor, U0126, significantly blocks TRAIL mediated
NF-kappaB activation and subsequent
MMP-9 induction
Zhang et al., Zhonghua Xue Ye Xue Za Zhi 2008
(Multiple Myeloma) :
BDNF plays an important role in the angiogenesis of MM to promote the up-regulation of
MMP-9 , which may be
induced by enhanced
NF-kappaB activity in MM cells
Kim et al., Mol Cancer Res 2008
(Glioma) :
Here, we report that the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin ( 17-AAG ) blocks
MMP-9 secretion and that HA-induced nuclear factor-kappaB (NF-kappaB) activation is
mediated by
IkappaB kinase , which phosphorylates the NF-kappaB inhibitor IkappaBalpha and promotes its degradation ... Based on our data, we propose that 17-AAG is a candidate drug for treatment of highly invasive gliomas resulting from HA-induced,
NF-kappaB mediated
MMP-9 secretion
Yagi et al., Stroke 2009
(Brain Ischemia...) :
We demonstrate that edaravone inhibits rtPA induced cerebral hemorrhage in the ischemic brain of rats via the inhibition of MMP-9 expression in vivo, which is substantiated by inhibition of
MMP-9 expression and
NF-kappaB activation in HBECs
Ju et al., Exp Mol Med 2009
(AIDS Dementia Complex...) :
Taken together, our results indicate that HIV-1 Tat can up-regulate expression of
MMP-9 via
MAPK-NF-kappaB dependent mechanisms as well as Tat induced TNF-alpha production in astrocytes
Wu et al., Cancer Lett 2009
(Carcinoma, Hepatocellular...) :
Inhibition of
NF-kappaB activity significantly reduced proliferation and invasion of Hep3B cells as well as
down-regulated the expression of invasion related molecules including matrix metalloproteinase (MMP)-2,
MMP-9 , membrane type-1 MMP (MT1-MMP), urokinase plasminogen activator (uPA) and vascular endothelial growth factor ( VEGF )
Castier et al., Antioxid Redox Signal 2009
:
Hence, induction of
NF-kappaB by shear stress
contributes to
MMP induction and allows long-term flow induced vascular enlargement
Park et al., Carcinogenesis 2009
(Breast Neoplasms...) :
Using specific inhibitors, we confirmed that PMA induced cell invasion and
MMP-9 expression is primarily
regulated by
nuclear factor-kappa B (NF-kappaB) activation via phosphatidylinositol 3-kinase (PI3K)/Akt and activator protein-1 (AP-1) activation via extracellular signal regulated kinase ( ERK ) 1/2
Yu et al., Nutr Metab Cardiovasc Dis 2010
:
In this study, we investigated the effects of curcumin on tumor necrosis factor-alpha (TNF-alpha) induced cell migration, the formation of intracellular reactive oxygen species ( ROS ), the translocation of
nuclear factor-kappaB (NFkappaB) and the
activation and expression of
MMP-9 in human aortic smooth muscle cells ( HASMCs )
Oh et al., Gynecol Oncol 2009
(Adenocarcinoma...) :
The transcriptional
activation of
MMP-9 by
NF-kappaB was up-regulated in syndecan-1 overexpression ... These findings provide evidence that supports that syndecan-1 may have a critical role in carcinogenic progression, particularly, contributing to the development of proliferative and invasive phenotype through
NF-kappaB mediated
MMP-9 gene expression in endometrial cancer
Qi et al., Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2009
:
Curcumin can restrain expression of MMP-2 and
MMP-9 in cystiform tissue of air-pouch animal models, and expression of MMP-2 and MMP-9 may be
regulated by the activation of
NF-kappaB
Lin et al., Cell Signal 2009
:
These results suggested that in A549 cells, the activation of p42/p44 MAPK, p38 MAPK, JNK1/2,
NF-kappaB , and AP-1 are
essential for the IL-1 beta induced
MMP-9 gene expression and cell migration
Gordon et al., J Cell Physiol 2009
:
Our data suggest TGF-beta mediated
MMP-9 induction may be
regulated by the
NF-kappaB , Smad3, and JNK pathways, whereas the IL-1beta mediated induction may be regulated by the NF-kappaB and p38 pathways
Sheng et al., J Huazhong Univ Sci Technolog Med Sci 2009
:
The relation between the expression and activity of
MMP-9 in C-reactive protein (CRP) induced human THP-1 mononuclear cells and the
activation of
nuclear factor kappa-B (NF-kappaB) was studied to investigate the possible role of CRP in plaque destabilization
Lee et al., Exp Dermatol 2010
:
In addition, NF-kappaB or JNK mediated the MMP-1 expression induced by TLR2, TLR3 and TLR5, whereas
NF-kappaB , JNK or p38 MAPK
mediated the
MMP-9 expression induced by TLR2, TLR3 and TLR5
Hsieh et al., Neurotox Res 2010
:
Taken together, these results suggested that in RBA-1 cells, activation of
NF-kappaB by a c-Src dependent PI3K/Akt-p42/p44 MAPK activation mediated through transactivation of PDGFR is
essential for
MMP-9 gene upregulation induced by LTA
Tacon et al., Am J Respir Cell Mol Biol 2010
(Inflammation...) :
We therefore investigated the
role of
NF-kappaB in HRV induced
MMP-9 expression ... The
role of
NF-kappaB in HRV induced
MMP-9 expression was further confirmed using MMP-9 promoter luciferase constructs, which demonstrated that an NF-kappaB site at -620/-607 base pairs was necessary for HRV induced MMP-9 expression
Shin et al., J Med Food 2009
(Carcinoma, Hepatocellular...) :
They also inhibited expression of matrix metalloproteinase (MMP)-2 and
MMP-9 and
activation of
nuclear factor kappaB (NF-kappaB) stimulated by tumor necrosis factor alpha
Choi et al., Food Chem Toxicol 2010
(Lung Neoplasms...) :
Suppression of PMA induced tumor cell invasion and metastasis by aqueous extract isolated from Prunella vulgaris via the inhibition of
NF-kappaB dependent
MMP-9 expression
Kim et al., Neurochem Int 2010
(Parkinson Disease) :
These results collectively suggest that ROS, PI3 kinase,
NF-kappaB , and AP-1 are commonly
involved in 6-OHDA- and MPP ( + ) -induced
MMP-9 gene expression, and that p38 MAPK is differentially involved
Bahar-Shany et al., J Cell Physiol 2010
:
Employing specific inhibitors we established that the induction of
MMP-9 by TNFalpha was
dependent on the activity of the epidermal growth factor receptor, c-Jun-N-terminal kinase (JNK),
NFkappaB and extracellular signal regulated kinase-1/2
Park et al., Mol Cells 2010
(MAP Kinase Signaling System...) :
Furthermore, as evidenced by MMP-9 promoter assays, melittin
inhibited MMP-9 gene expression by blocking the PMA stimulated activations of activator protein-1 (AP-1) and
nuclear factor-kappa B (NF-kappaB)
Kim et al., Immune network 2009
:
Stimulation of CD147 with its specific monoclonal antibody induced the expression of
matrix metalloproteinase (MMP)-9 in THP-1 cells and it was
suppressed by inhibitors of both ERK and
NF-kappaB
Moon et al., Int Immunopharmacol 2010
(Arthritis, Experimental...) :
Additionally, by altering
nuclear factor (NF)-kappaB transcription activity in FLSs, curcumin
inhibited PGE ( 2 ) production, COX-2 expression, and
MMP secretion
Tobar et al., Mol Cell Biochem 2010
:
Our results shows that TGF-beta1 stimulation of uPA and
MMP-9 expression
involve NOXs dependent ROS and
NFkappaB , activation, demonstrated by using DPI, NOXs inhibitor, ROS scavenger N-acetylcysteine and SN50, an NFkb inhibitor ... Thus,
ROS-NFkappaB acts as the crucial signal in TGF-beta1 induced uPA and
MMP-9 expression thereby mediating the enhancement of cellular malignity by TGF-beta1
Martinez-Orozco et al., Eur J Cell Biol 2010
(Neoplasm Invasiveness) :
We demonstrate here that AA promotes an increase in vimentin and N-cadherin expression,
MMP-9 secretion, a decrease in E-cadherin junctional levels, and the
activation of FAK, Src and
NF-kappaB in MCF10A cells ... We demonstrate here that AA promotes an increase in vimentin and N-cadherin expression,
MMP-9 secretion, a decrease in E-cadherin junctional levels, and the
activation of FAK, Src and
NF-kappaB in MCF10A cells
Liu et al., Cancer Lett 2010
(Prostatic Neoplasms) :
In this study, we investigated the roles of OPN in human prostate cancer cells and provided clues about the possible functions of IkappaB kinase (IKK) in
NF-kappaB mediated OPN induced activations of MMP-2 and
MMP-9
Bangaru et al., Anticancer Res 2010
(Cerebellar Neoplasms...) :
The expression of both bcl-2 and
MMP-9 is
regulated by the transcription factor
NF-kappaB
Liu et al., Mol Nutr Food Res 2010
(Adenocarcinoma...) :
Nuclear factor (NF)-kappaB inhibitor
induced a marked reduction in
MMP-9 and MMP-2 expression, suggesting NF-kappaB pathway could play an important role
Ho et al., Food Chem Toxicol 2010
(Adenocarcinoma...) :
It is possible that the suppressive effect of GA on
MMP-2/9 might
involve the inhibition of
NF-kappaB activity
Balasubramanian et al., J Biol Chem 2011
:
The interferon-gamma induced GTPase, mGBP-2,
inhibits tumor necrosis factor alpha (TNF-alpha) induction of
matrix metalloproteinase-9 (MMP-9) by inhibiting
NF-kappaB and Rac protein
Zhao et al., Behav Brain Res 2013
(Diabetes Mellitus, Experimental) :
Inhibition of
NF-kappaB activation by Pyrrolidine dithiocarbamate partially
attenuates hippocampal
MMP-9 activation and improves cognitive deficits in streptozotocin induced diabetic rats
Chen et al., Exp Lung Res 2013
(Carcinoma, Non-Small-Cell Lung...) :
In addition, we found that the knockdown of NUAK1 suppressed the expression of MMP-2 and
MMP-9 and the
activation of
NF-kB , which can regulate the transcription of MMP-2 and MMP-9
Sato et al., J Biol Chem 1993
:
Binding sites for
NF-kB , Sp-1, and AP-1 are reportedly
required for induction of
MMP-9 gene expression by tumor necrosis factor-alpha or 12-O-tetradecanoylphorbol-13-acetate
Yoshizaki et al., Proc Natl Acad Sci U S A 1998
(Cell Transformation, Neoplastic...) :
Here we report that binding sites for
NF-kappaB , SP-1, and AP-1 also
contribute to induction of the
MMP9 promoter by the viral protein, LMP1, mainly through the NF-kappaB and, to a lesser extent, the SP-1 and AP-1 sites
Bond et al., FEBS Lett 1998
(Inflammation) :
Using a recently developed adenovirus that overexpresses the inhibitory subunit, IkappaB alpha, we demonstrated an absolute
requirement for
NF-kappaB in upregulation of
MMP-9 ... Activation of
NF-kappaB binding by inflammatory cytokines was therefore
necessary but not sufficient for synergistic upregulation of
MMP-9