Gene interactions and pathways from curated databases and text-mining
FEBS Lett 2005, PMID: 16288746

Platelet-activating factor induces matrix metalloproteinase-9 expression through Ca(2+)- or PI3K-dependent signaling pathway in a human vascular endothelial cell line.

Ko, Hyun-Mi; Kang, Jee-Hae; Choi, Jung-Hwa; Park, Sung Jun; Bai, Suk; Im, Suhn-Young

Platelet-activating factor (PAF) augments angiogenesis by promoting the synthesis of a variety of angiogenic factors, via the nuclear factor (NF)-kappaB activation. Recently, we reported that PAF upregulates MMP-9 expression in a NF-kappaB-dependent manner. In this study, we investigated the signaling pathway involved in PAF-induced MMP-9 expression in ECV304 cells. Our current data indicate that the Ca(2+)- or phosphatidylinositol 3-kinase (PI3K)-dependent signaling pathway is necessary for PAF-induced MMP-9 expression. Furthermore, PAF-induced NF-kappaB activation was blocked by selective inhibitors of Ca(2+), PI3K, or extracellular signal-regulated kinase (ERK). Our results suggest that PAF-induced MMP-9 expression, in a NF-kappaB-dependent manner, is regulated by Ca(2+), PI3K and ERK signaling pathways.

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Text Mining Data

MMP-9 → PAF: " Recently, we reported that PAF upregulates MMP-9 expression in a NF-kappaB dependent manner "

MMP-9 — NF-kappaB: " Recently, we reported that PAF upregulates MMP-9 expression in a NF-kappaB dependent manner "

MMP-9 → PAF: " In this study, we investigated the signaling pathway involved in PAF induced MMP-9 expression in ECV304 cells "

MMP-9 → PAF: " Our current data indicate that the Ca ( 2+ ) - or phosphatidylinositol 3-kinase (PI3K) dependent signaling pathway is necessary for PAF induced MMP-9 expression "

NF-kappaB ⊣ PI3K: " Furthermore, PAF induced NF-kappaB activation was blocked by selective inhibitors of Ca ( 2+ ), PI3K , or extracellular signal regulated kinase ( ERK ) "

NF-kappaB ⊣ PI3K: " Furthermore, PAF induced NF-kappaB activation was blocked by selective inhibitors of Ca ( 2+ ), PI3K , or extracellular signal regulated kinase ( ERK ) "

NF-kappaB → PAF: " Furthermore, PAF induced NF-kappaB activation was blocked by selective inhibitors of Ca ( 2+ ), PI3K, or extracellular signal regulated kinase ( ERK ) "

MMP-9 → PAF: " Our results suggest that PAF induced MMP-9 expression, in a NF-kappaB dependent manner, is regulated by Ca ( 2+ ), PI3K and ERK signaling pathways "

MMP-9 → ERK: " Our results suggest that PAF induced MMP-9 expression, in a NF-kappaB dependent manner, is regulated by Ca ( 2+ ), PI3K and ERK signaling pathways "

MMP-9 → PI3K: " Our results suggest that PAF induced MMP-9 expression, in a NF-kappaB dependent manner, is regulated by Ca ( 2+ ), PI3K and ERK signaling pathways "

ERK — NF-kappaB: " Our results suggest that PAF induced MMP-9 expression, in a NF-kappaB dependent manner, is regulated by Ca ( 2+ ), PI3K and ERK signaling pathways "

MMP-9 — NF-kappaB: " Our results suggest that PAF induced MMP-9 expression, in a NF-kappaB dependent manner, is regulated by Ca ( 2+ ), PI3K and ERK signaling pathways "

PI3K — NF-kappaB: " Our results suggest that PAF induced MMP-9 expression, in a NF-kappaB dependent manner, is regulated by Ca ( 2+ ), PI3K and ERK signaling pathways "

Manually curated Databases

No curated data.