◀ Back to IL2

IL2 — IL2RB

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: IL2RB → IL2 (increases, IL2 Activity)
  Evidence: See Appendix IV: Chemokines and Their Receptors
• BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → SOCS3 (modification, activates)
• BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → SOCS1 (modification, activates)
• BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → IRS-1 (IRS1) (modification, activates)
• BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → SHP-1 (PTPN6) (modification, activates)
• BioCarta il 2 signaling pathway: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3/LCK/SYK complex (IL2-IL2RA-JAK3-JAK1-SYK-IL2RG-IL2RB-LCK) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• BioCarta il-2 receptor beta chain in t cell activation: SOCS3 → IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) (modification, inhibits)
  
• BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → CBL (modification, activates)
• BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → SHP-1 (PTPN6) (modification, activates)
• BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → SOCS1 (modification, activates)
• BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• BioCarta il-2 receptor beta chain in t cell activation: IL-2 (IL2) → IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-IL2RA-IL2RG-JAK1-JAK3) (modification, collaborate)
  
• BioCarta il-2 receptor beta chain in t cell activation: IL-2 (IL2) → IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) (modification, collaborate)
  
• BioCarta il-2 receptor beta chain in t cell activation: IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-IL2RA-IL2RG-JAK1-JAK3) → IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) (modification, collaborate)
  
• BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → SOCS3 (modification, activates)
• BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → SOCS1 (modification, activates)
• BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → Nmi/STAT5 complex (NMI-STAT5A_STAT5B) (modification, activates)
  
• BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → SHP-1 (PTPN6) (modification, activates)
• BioCarta il 2 signaling pathway: SYK → IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) (modification, collaborate)
  
• BioCarta il 2 signaling pathway: SYK → IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3/LCK/SYK complex (IL2-IL2RA-JAK3-JAK1-SYK-IL2RG-IL2RB-LCK) (modification, collaborate)
  
• BioCarta il 2 signaling pathway: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → LCK (modification, collaborate)
• BioCarta il 2 signaling pathway: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3/LCK/SYK complex (IL2-IL2RA-JAK3-JAK1-SYK-IL2RG-IL2RB-LCK) (modification, collaborate)
  
• BioCarta il 2 signaling pathway: LCK → IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3/LCK/SYK complex (IL2-IL2RA-JAK3-JAK1-SYK-IL2RG-IL2RB-LCK) (modification, collaborate)
  
• BioCarta il-2 receptor beta chain in t cell activation: SOCS3 → IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) (modification, inhibits)
  
• BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → CRKL (modification, activates)
• BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → SHP-1 (PTPN6) (modification, activates)
• BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → SOCS1 (modification, activates)
• KEGG Measles: IL2 → IL2RA/IL2RB/IL2RG (protein-protein, activation)
• KEGG Cytokine-cytokine receptor interaction: IL2 → Complex of IL2RA-IL2RB-IL2RG (protein-protein, activation)
  
• KEGG Cytokine-cytokine receptor interaction: IL2 → Complex of IL2RB-IL2RG (protein-protein, activation)
• NCI Pathway Database IL2-mediated signaling events: IL2R gamma/JAK3/SOCS1 complex (IL2RG-JAK3-SOCS1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) (modification, inhibits)
  Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
  Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → IL2R alpha (IL2RA) (modification, collaborate) Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
  Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → IL2R beta/JAK1/LCK complex (IL2RB-JAK1-LCK) (modification, collaborate)
  Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
  Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → IL2 (IL2) (modification, collaborate) Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
  Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → IL2R gamma/JAK3 complex (IL2RG-JAK3) (modification, collaborate)
  Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
  Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2R beta/JAK1/LCK/SOCS3 complex (IL2RB-JAK1-LCK-SOCS3) → IL2 (IL2) (modification, inhibits) Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
  Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2R beta/JAK1/LCK/SOCS1 complex (IL2RB-JAK1-LCK-SOCS1) → IL2 (IL2) (modification, inhibits) Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
  Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2R beta/JAK1/LCK complex (IL2RB-JAK1-LCK) → IL2 (IL2) (modification, collaborate) Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
  Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2 (IL2) → IL2R beta/JAK1/LCK/CISH complex (IL2RB-JAK1-LCK-CISH) (modification, collaborate)
  Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
  Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → Aiolos (IKZF3) (modification, activates) Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → RasGAP/Dok-R complex (RASA1-DOK2) (modification, activates)
  Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → SOCS3/RasGAP complex (SOCS3-RASA1) (modification, activates)
  Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → None (modification, activates) Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → RAS family/GDP/Aiolos complex (HRAS_KRAS_HRAS_KRAS_NRAS-IKZF3) (modification, activates)
  Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → None (modification, activates) Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/PYK2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-PTK2B) (modification, collaborate)
  Miyazaki et al., Genes Dev 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → PYK2 (PTK2B) (modification, collaborate) Miyazaki et al., Genes Dev 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/PYK2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-PTK2B) → PYK2 (PTK2B) (modification, collaborate) Miyazaki et al., Genes Dev 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL2 signaling events mediated by PI3K: None → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) (modification, collaborate)
  Augustine et al., Mol Cell Biol 1991, Gómez et al., J Immunol 1997
  Evidence: assay, other species
• NCI Pathway Database IL2 signaling events mediated by PI3K: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) → PKC zeta (PRKCZ) (modification, activates) Gómez et al., Exp Cell Res 1995, Gómez et al., J Immunol 1997
  Evidence: mutant phenotype, other species
• NCI Pathway Database IL2-mediated signaling events: IL2R beta/JAK1/LCK complex (IL2RB-JAK1-LCK) → IL2 (IL2) (modification, collaborate) Delespine-Carmagnat et al., FEBS Lett 1999, Tsujino et al., Genes Cells 1999, Tsujino et al., Proc Natl Acad Sci U S A 2000, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, González-García et al., J Biol Chem 1997, Fujii et al., EMBO J 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) (modification, collaborate)
  Burns et al., J Biol Chem 1993, Ravichandran et al., J Biol Chem 1994, Ravichandran et al., Proc Natl Acad Sci U S A 1996, Friedmann et al., Proc Natl Acad Sci U S A 1996, Lord et al., J Immunol 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1) → SHC (SHC1) (modification, collaborate) Burns et al., J Biol Chem 1993, Ravichandran et al., J Biol Chem 1994, Ravichandran et al., Proc Natl Acad Sci U S A 1996, Friedmann et al., Proc Natl Acad Sci U S A 1996, Lord et al., J Immunol 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → SHC (SHC1) (modification, collaborate) Burns et al., J Biol Chem 1993, Ravichandran et al., J Biol Chem 1994, Ravichandran et al., Proc Natl Acad Sci U S A 1996, Friedmann et al., Proc Natl Acad Sci U S A 1996, Lord et al., J Immunol 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2R beta/JAK1/LCK complex (IL2RB-JAK1-LCK) → IL2/IL2R beta/gamma/JAK1/LCK/JAK3 complex (IL2RB-JAK1-LCK-IL2-IL2RG-JAK3) (modification, collaborate)
  Delespine-Carmagnat et al., FEBS Lett 1999, Tsujino et al., Genes Cells 1999, Tsujino et al., Proc Natl Acad Sci U S A 2000, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, González-García et al., J Biol Chem 1997, Fujii et al., EMBO J 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2 (IL2) → IL2/IL2R beta/gamma/JAK1/LCK/JAK3 complex (IL2RB-JAK1-LCK-IL2-IL2RG-JAK3) (modification, collaborate)
  Delespine-Carmagnat et al., FEBS Lett 1999, Tsujino et al., Genes Cells 1999, Tsujino et al., Proc Natl Acad Sci U S A 2000, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, González-García et al., J Biol Chem 1997, Fujii et al., EMBO J 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2R gamma/JAK3 complex (IL2RG-JAK3) → IL2/IL2R beta/gamma/JAK1/LCK/JAK3 complex (IL2RB-JAK1-LCK-IL2-IL2RG-JAK3) (modification, collaborate)
  Delespine-Carmagnat et al., FEBS Lett 1999, Tsujino et al., Genes Cells 1999, Tsujino et al., Proc Natl Acad Sci U S A 2000, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, González-García et al., J Biol Chem 1997, Fujii et al., EMBO J 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R beta/gamma/JAK1/LCK/JAK3 complex (IL2RB-JAK1-LCK-IL2-IL2RG-JAK3) → PKC beta (PRKCB) (modification, activates) Gómez et al., Exp Cell Res 1995
  Evidence: mutant phenotype, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → Dok-R (DOK2) (modification, activates) Nelms et al., Immunity 1998
• NCI Pathway Database SHP2 signaling: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database SHP2 signaling: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database SHP2 signaling: PI3K complex (PIK3CA-PIK3R1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database SHP2 signaling: RHOA/GTP complex (RHOA) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, activates)
  Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL2-mediated signaling events: STAT1 (STAT1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) (modification, collaborate)
  Delespine-Carmagnat et al., Eur J Immunol 2000, Frank et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995
  Evidence: assay, physical interaction
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → STAT1 (dimer) complex (STAT1) (modification, activates)
  Delespine-Carmagnat et al., Eur J Immunol 2000, Frank et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995
  Evidence: assay, physical interaction
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: IL2/IL2R complex (IL2RA-IL2RB-IL2RG-IL2) → OX40 (TNFRSF4) (transcription, activates) Verdeil et al., J Immunol 2006*
  Evidence: expresssion pattern
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/IRS1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-IRS2_IRS1) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Johnston et al., J Biol Chem 1995
  Evidence: physical interaction
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/IRS1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-IRS2_IRS1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/IRS1-2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-IRS2_IRS1-PIK3CA-PIK3R1) (modification, collaborate)
  Johnston et al., J Biol Chem 1995
  Evidence: physical interaction
• NCI Pathway Database IL2-mediated signaling events: PI3K complex (PIK3CA-PIK3R1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/IRS1-2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-IRS2_IRS1-PIK3CA-PIK3R1) (modification, collaborate)
  Johnston et al., J Biol Chem 1995
  Evidence: physical interaction
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) (modification, collaborate)
  Gu et al., Mol Cell Biol 2000, Zhu et al., J Biol Chem 1994, Ravichandran et al., J Biol Chem 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1) → GAB2/GRB2/SOS1 complex (GRB2-SOS1-GAB2) (modification, collaborate)
  Gu et al., Mol Cell Biol 2000, Zhu et al., J Biol Chem 1994, Ravichandran et al., J Biol Chem 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → GAB2/GRB2/SOS1 complex (GRB2-SOS1-GAB2) (modification, collaborate)
  Gu et al., Mol Cell Biol 2000, Zhu et al., J Biol Chem 1994, Ravichandran et al., J Biol Chem 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: Erk1-2-active (MAPK3/MAPK1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL2-mediated signaling events: Erk1-2-active (MAPK3/MAPK1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/ERK1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-MAPK3_MAPK1) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL2-mediated signaling events: Erk1-2-active (MAPK3/MAPK1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → SHP2 (PTPN11) (modification, collaborate) Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/ERK1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-MAPK3_MAPK1) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL2-mediated signaling events: SHP2 (PTPN11) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/ERK1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-MAPK3_MAPK1) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL2-mediated signaling events: SHP2 (PTPN11) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/ERK1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-MAPK3_MAPK1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL2-mediated signaling events: IL2R beta/JAK1/LCK/SOCS3 complex (IL2RB-JAK1-LCK-SOCS3) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) (modification, inhibits)
  Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Delespine-Carmagnat et al., Eur J Immunol 2000, Gilmour et al., Proc Natl Acad Sci U S A 1995, Gaffen et al., Proc Natl Acad Sci U S A 1995, Johnston et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995, Lin et al., Immunity 1995, Fujii et al., Proc Natl Acad Sci U S A 1995, Wakao et al., EMBO J 1995, Beadling et al., EMBO J 1994, Friedmann et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Liu et al., Curr Biol 1997, Fujii et al., EMBO J 1998
  Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2R beta/JAK1/LCK/SOCS1 complex (IL2RB-JAK1-LCK-SOCS1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) (modification, inhibits)
  Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Delespine-Carmagnat et al., Eur J Immunol 2000, Gilmour et al., Proc Natl Acad Sci U S A 1995, Gaffen et al., Proc Natl Acad Sci U S A 1995, Johnston et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995, Lin et al., Immunity 1995, Fujii et al., Proc Natl Acad Sci U S A 1995, Wakao et al., EMBO J 1995, Beadling et al., EMBO J 1994, Friedmann et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Liu et al., Curr Biol 1997, Fujii et al., EMBO J 1998
  Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → STAT5 (STAT5A/STAT5B) (modification, activates) Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Delespine-Carmagnat et al., Eur J Immunol 2000, Gilmour et al., Proc Natl Acad Sci U S A 1995, Gaffen et al., Proc Natl Acad Sci U S A 1995, Johnston et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995, Lin et al., Immunity 1995, Fujii et al., Proc Natl Acad Sci U S A 1995, Wakao et al., EMBO J 1995, Beadling et al., EMBO J 1994, Friedmann et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Liu et al., Curr Biol 1997, Fujii et al., EMBO J 1998
  Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → STAT5 (dimer)-active (STAT5B/STAT5A) (modification, activates)
  Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Delespine-Carmagnat et al., Eur J Immunol 2000, Gilmour et al., Proc Natl Acad Sci U S A 1995, Gaffen et al., Proc Natl Acad Sci U S A 1995, Johnston et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995, Lin et al., Immunity 1995, Fujii et al., Proc Natl Acad Sci U S A 1995, Wakao et al., EMBO J 1995, Beadling et al., EMBO J 1994, Friedmann et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Liu et al., Curr Biol 1997, Fujii et al., EMBO J 1998
  Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B) → IL2/IL2R complex (IL2RA-IL2RB-IL2RG-IL2) (modification, activates)
  
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: IL2 (IL2) → IL2R complex (IL2RA-IL2RB-IL2RG) (modification, collaborate)
  
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: IL2 (IL2) → IL2/IL2R complex (IL2RA-IL2RB-IL2RG-IL2) (modification, collaborate)
  
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: IL2R complex (IL2RA-IL2RB-IL2RG) → IL2/IL2R complex (IL2RA-IL2RB-IL2RG-IL2) (modification, collaborate)
  
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R beta/gamma/JAK1/Fyn/JAK3 complex (IL2RB-JAK1-FYN-IL2-IL2RG-JAK3) → IL2/IL2R beta/gamma/JAK1/Fyn/JAK3/PI3K complex (IL2RB-JAK1-FYN-IL2-IL2RG-JAK3-PIK3CA-PIK3R1) (modification, collaborate)
  Augustine et al., Mol Cell Biol 1991
  Evidence: assay, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R beta/gamma/JAK1/Fyn/JAK3 complex (IL2RB-JAK1-FYN-IL2-IL2RG-JAK3) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Augustine et al., Mol Cell Biol 1991
  Evidence: assay, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R beta/gamma/JAK1/Fyn/JAK3/PI3K complex (IL2RB-JAK1-FYN-IL2-IL2RG-JAK3-PIK3CA-PIK3R1) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Augustine et al., Mol Cell Biol 1991
  Evidence: assay, other species
• NCI Pathway Database IL2 signaling events mediated by PI3K: None → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) (modification, activates)
  Gu et al., Mol Cell Biol 2000, Lindemann et al., J Biol Chem 2003, Akbar et al., Eur J Immunol 1996, Ahmed et al., Proc Natl Acad Sci U S A 1997, Reif et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R beta/gamma/JAK1/LCK/JAK3/PI3K complex (IL2RB-JAK1-LCK-IL2-IL2RG-JAK3-PIK3CA-PIK3R1) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Tsujino et al., Genes Cells 1999, Merida et al., J Immunol 1991, Taichman et al., J Biol Chem 1993, González-García et al., J Biol Chem 1997
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R beta/gamma/JAK1/LCK/JAK3/PI3K complex (IL2RB-JAK1-LCK-IL2-IL2RG-JAK3-PIK3CA-PIK3R1) → IL2/IL2R beta/gamma/JAK1/LCK/JAK3 complex (IL2RB-JAK1-LCK-IL2-IL2RG-JAK3) (modification, collaborate)
  Tsujino et al., Genes Cells 1999, Merida et al., J Immunol 1991, Taichman et al., J Biol Chem 1993, González-García et al., J Biol Chem 1997
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: PI3K complex (PIK3CA-PIK3R1) → IL2/IL2R beta/gamma/JAK1/LCK/JAK3 complex (IL2RB-JAK1-LCK-IL2-IL2RG-JAK3) (modification, collaborate)
  Tsujino et al., Genes Cells 1999, Merida et al., J Immunol 1991, Taichman et al., J Biol Chem 1993, González-García et al., J Biol Chem 1997
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database SHP2 signaling: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → SHP2 (PTPN11) (modification, collaborate) Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997, Gadina et al., J Immunol 1999
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997, Gadina et al., J Immunol 1999
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: PI3K complex (PIK3CA-PIK3R1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997, Gadina et al., J Immunol 1999
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database SHP2 signaling: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL2-mediated signaling events: RHOA/GTP complex (RHOA) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, activates)
  Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997, Gadina et al., J Immunol 1999
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database SHP2 signaling: SHP2 (PTPN11) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL2 signaling events mediated by STAT5: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) → STAT5 (dimer)-active (STAT5B/STAT5A) (transcription, activates)
  Moriggl et al., Immunity 1999, Brennan et al., Immunity 1997
  Evidence: mutant phenotype, other species
• NCI Pathway Database IL12-mediated signaling events: STAT3 (STAT3) → IL2/IL2R complex (IL2RA-IL2RB-IL2RG-IL2) (modification, collaborate)
  Gollob et al., J Immunol 1999
  Evidence: mutant phenotype, assay
• NCI Pathway Database IL12-mediated signaling events: IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2) → IL2/IL2R complex (IL2RA-IL2RB-IL2RG-IL2) (modification, activates)
  Gollob et al., J Immunol 1999
  Evidence: mutant phenotype, assay
• NCI Pathway Database IL12-mediated signaling events: p38 alpha (MAPK14) → IL2/IL2R complex (IL2RA-IL2RB-IL2RG-IL2) (modification, activates)
  Gollob et al., J Immunol 1999
  Evidence: mutant phenotype, assay
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R beta/gamma/JAK1/Fyn/JAK3 complex (IL2RB-JAK1-FYN-IL2-IL2RG-JAK3) → IL2 (IL2) (modification, collaborate) Kobayashi et al., Proc Natl Acad Sci U S A 1993
  Evidence: assay, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R beta/gamma/JAK1/Fyn/JAK3 complex (IL2RB-JAK1-FYN-IL2-IL2RG-JAK3) → IL2R gamma/JAK3 complex (IL2RG-JAK3) (modification, collaborate)
  Kobayashi et al., Proc Natl Acad Sci U S A 1993
  Evidence: assay, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R beta/gamma/JAK1/Fyn/JAK3 complex (IL2RB-JAK1-FYN-IL2-IL2RG-JAK3) → IL2R beta/JAK1/Fyn complex (IL2RB-JAK1-FYN) (modification, collaborate)
  Kobayashi et al., Proc Natl Acad Sci U S A 1993
  Evidence: assay, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2 (IL2) → IL2R beta/JAK1/Fyn complex (IL2RB-JAK1-FYN) (modification, collaborate)
  Kobayashi et al., Proc Natl Acad Sci U S A 1993
  Evidence: assay, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IRS1-2 (IRS2/IRS1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) (modification, collaborate)
  Johnston et al., J Biol Chem 1995
  Evidence: physical interaction
• NCI Pathway Database IL2-mediated signaling events: IRS1-2 (IRS2/IRS1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/IRS1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-IRS2_IRS1) (modification, collaborate)
  Johnston et al., J Biol Chem 1995
  Evidence: physical interaction
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/IRS1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-IRS2_IRS1) (modification, collaborate)
  Johnston et al., J Biol Chem 1995
  Evidence: physical interaction
• NCI Pathway Database IL2-mediated signaling events: RAF1 (RAF1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) (modification, activates)
  Blanchard et al., Oncogene 2000, Lundin Brockdorff et al., Cytokine 2002, Karnitz et al., Mol Cell Biol 1995
  Evidence: mutant phenotype, other species
• NCI Pathway Database IL2-mediated signaling events: SYK (SYK) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) (modification, collaborate)
  Zhou et al., Mol Cell Biol 2000, Jiang et al., Blood 2003, Minami et al., Immunity 1995
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL2-mediated signaling events: SYK (SYK) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SYK complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SYK) (modification, collaborate)
  Zhou et al., Mol Cell Biol 2000, Jiang et al., Blood 2003, Minami et al., Immunity 1995
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SYK complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SYK) (modification, collaborate)
  Zhou et al., Mol Cell Biol 2000, Jiang et al., Blood 2003, Minami et al., Immunity 1995
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL12-mediated signaling events: STAT1 (STAT1) → IL2/IL2R complex (IL2RA-IL2RB-IL2RG-IL2) (modification, collaborate)
  Gollob et al., J Immunol 1999
  Evidence: mutant phenotype, assay
• NCI Pathway Database IL12-mediated signaling events: IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2) → IL2/IL2R complex (IL2RA-IL2RB-IL2RG-IL2) (modification, activates)
  Gollob et al., J Immunol 1999
  Evidence: mutant phenotype, assay
• NCI Pathway Database IL12-mediated signaling events: p38 alpha (MAPK14) → IL2/IL2R complex (IL2RA-IL2RB-IL2RG-IL2) (modification, activates)
  Gollob et al., J Immunol 1999
  Evidence: mutant phenotype, assay
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1) → p38alpha-beta-active (MAPK14/MAPK11) (modification, activates)
  Hunt et al., J Biol Chem 1999, Crawley et al., J Biol Chem 1997
  Evidence: mutant phenotype, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1) → p38alpha-beta (MAPK14/MAPK11) (modification, activates)
  Hunt et al., J Biol Chem 1999, Crawley et al., J Biol Chem 1997
  Evidence: mutant phenotype, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SYK complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SYK) → PI3K complex (PIK3CA-PIK3R1) (modification, activates)
  Jiang et al., Blood 2003
  Evidence: mutant phenotype
• NCI Pathway Database IL2-mediated signaling events: None → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) (modification, collaborate)
  Gómez et al., J Immunol 1997
  Evidence: mutant phenotype, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → RHOA/GTP complex (RHOA) (modification, activates) Gómez et al., J Immunol 1997
  Evidence: mutant phenotype, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → RHOA/GDP complex (RHOA) (modification, activates) Gómez et al., J Immunol 1997
  Evidence: mutant phenotype, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → None (modification, activates) Gómez et al., J Immunol 1997
  Evidence: mutant phenotype, other species
• NCI Pathway Database IL2-mediated signaling events: PP2A (PPP2R5D) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) (positive regulation of cell-cell adhesion, collaborate)
  Brockdorff et al., Cytokine 1997
  Evidence: mutant phenotype, other species
• NCI Pathway Database SHP2 signaling: RAF1 (RAF1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) (modification, activates)
  Blanchard et al., Oncogene 2000, Lundin Brockdorff et al., Cytokine 2002, Karnitz et al., Mol Cell Biol 1995
  Evidence: mutant phenotype
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/STAM1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-STAM2_STAM) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) (modification, collaborate)
  Endo et al., FEBS Lett 2000, Takeshita et al., Immunity 1997
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/STAM1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-STAM2_STAM) → STAM1-2 (STAM2/STAM) (modification, collaborate) Endo et al., FEBS Lett 2000, Takeshita et al., Immunity 1997
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → STAM1-2 (STAM2/STAM) (modification, collaborate) Endo et al., FEBS Lett 2000, Takeshita et al., Immunity 1997
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL2 signaling events mediated by PI3K: IL2/IL2R beta/gamma/JAK1/LCK/JAK3/PI3K complex (IL2RB-JAK1-LCK-IL2-IL2RG-JAK3-PIK3CA-PIK3R1) → BCL-X (BCL2L1) (transcription, activates) González-García et al., J Biol Chem 1997
  Evidence: mutant phenotype, other species
• NCI Pathway Database IL2-mediated signaling events: STAT3 (STAT3) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) (modification, collaborate)
  Delespine-Carmagnat et al., Eur J Immunol 2000, Fung et al., Cell Signal 2003, Nielsen et al., Eur J Immunol 1994, Frank et al., Proc Natl Acad Sci U S A 1995, Johnston et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995, Lin et al., Immunity 1995, Ng et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → MEK1-2 (MAP2K1/MAP2K2) (modification, activates) Delespine-Carmagnat et al., Eur J Immunol 2000, Fung et al., Cell Signal 2003, Nielsen et al., Eur J Immunol 1994, Frank et al., Proc Natl Acad Sci U S A 1995, Johnston et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995, Lin et al., Immunity 1995, Ng et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction
• Reactome Reaction: IL2RB → IL2 (reaction) Zhou et al., Mol Cell Biol 2000, Rickert et al., J Mol Biol 2004, Stauber et al., Proc Natl Acad Sci U S A 2006, Johnston et al., Proc Natl Acad Sci U S A 1995, Johnston et al., Nature 1994, Friedmann et al., Proc Natl Acad Sci U S A 1996
• Reactome Reaction: IL2RB → IL2 (direct_complex) Friedmann et al., Proc Natl Acad Sci U S A 1996
• Reactome Reaction: IL2RB → IL2 (indirect_complex) Rickert et al., J Mol Biol 2004, Stauber et al., Proc Natl Acad Sci U S A 2006
• WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway: CSF3/EPO/IFNA7/CSH1/IFNA7/IFNA7/IFNA7/IFNA7/IFNA7/IFNA7/IFNA7/IFNA7/IFNB1/IL2/OSM/PRL/IFNA7/IFNA7 → IL3RA/IL2RB/IFNAR1/OSMR/PRLR/IL7R/IL6R/CSF3R/IL2RA/EPOR/IL4R/IL2RG/IFNAR2/GHR (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: IL2 — IL2RB Mills et al., J Biol Chem 1990
• IRef Bind_translation Interaction: IL2 — IL2RB (cross-linking study) Mills et al., J Biol Chem 1990
• MIPS CORUM IL2-IL2RA-IL2RB complex: IL2-IL2RA-IL2RB complex complex (IL2-IL2RA-IL2RB) Mills et al., J Biol Chem 1990
• IRef Dip Interaction: Complex of IL2RG-IL2-IL2RB-IL2-IL2RB-IL2RG-IL2-IL2RG-IL2RB (direct interaction, x-ray crystallography) Levin et al., Nature 2012*
• IRef Dip Interaction: IL2 — IL2RB (direct interaction, biophysical) Nakarai et al., J Exp Med 1994*
• IRef Dip Interaction: IL2 — IL2RB (direct interaction, isothermal titration calorimetry) Levin et al., Nature 2012*
• IRef Dip Interaction: IL2 — IL2RB (direct interaction, surface plasmon resonance) Levin et al., Nature 2012*
• IRef Hprd Interaction: IL2 — IL2RB (in vivo) Eckenberg et al., J Immunol 2000*, Johnson et al., Eur Cytokine Netw 1994*
• IRef Innatedb Interaction: Complex of IL2-IL2RA-IL2RB-IL2RA-IL2RB-IL2-IL2RB-IL2-IL2RA (unknown, -) Rickert et al., J Mol Biol 2004
• IRef Innatedb Interaction: IL2 — IL2RB (unknown, -) Rickert et al., J Mol Biol 2004
• IRef Innatedb Interaction: IL2 — IL2RB (unknown, -) Arima et al., J Immunol 1991
• IRef Innatedb Interaction: IL2 — IL2RB (unknown, -) Sharon et al., Science 1986
• IRef Innatedb Interaction: IL2 — IL2RB (unknown, -) Teshigawara et al., J Exp Med 1987*
• IRef Innatedb Interaction: Complex of IL2RA-IL2-IL2RB-IL2RB-IL2RG-IL2-IL2RA-IL2RG (unknown, -) de Jong et al., J Immunol 1996*
• IRef Ophid Interaction: IL2 — IL2RB (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Ishikawa et al., Int Immunol 1991 : Although IL-2 induced IL-2R p75 down-regulation was seen more quickly, IL-2 did not contribute to the process of the IL-4 induced decrease of IL-2R p75
Shameli et al., Eur J Immunol 2013 (Diabetes Mellitus, Type 1) : We show that decreased IL-2 production impairs the regulatory capacity of memory-like autoregulatory CD8 ( + ) CD122 ( + ) T cells
Pekalski et al., J Immunol 2013 : Although CD25 naive T cells respond to lower concentrations of IL-2 as compared with their CD25 counterparts, IL-2 responsiveness is further increased in CD31 naive T cells by their expression of the signaling IL-2 receptor ß-chain CD122 , forming with common ?-chain functional high-affinity IL-2 receptors
Granelli-Piperno et al., J Exp Med 1986 : Exogenous IL-2 had little ( IFN ) or no ( IL-2 ) effect on lymphokine mRNAs, but significantly increased c-myc, IL-2-R and heat shock protein mRNAs
Yodoi et al., J Immunol 1985 (Cell Transformation, Neoplastic...) : Furthermore, neither recombinant IL 2 nor gamma-interferon could induce IL 2-R on YT cells, suggesting the presence of a unique IL 2-R inducing factor in PBL or spleen CM
Nishimura et al., J Immunol 1989 : In contrast, IL-2 induced cell proliferation, IL-2R expression, and LFA-1 expression were enhanced by the addition of PMA
Reed et al., Proc Natl Acad Sci U S A 1986 : These data indicate that c-fos, c-myc, IL2 , and IL2R belong to a group of genes expressed early, whereas c-myb, N-ras, and TFR belong to a group of genes expressed later in PHA activated PBMC, and that the products of the c-fos and c-myc protooncogenes are not required for expression of IL2 or IL2R genes
Nagel et al., J Clin Invest 1988 : The results suggest that decreased expression of both IL2 and IL2R mRNA contributes to the low synthesis of IL2 and membrane IL2R , respectively, and is partially responsible for the diminished proliferative activity observed in lymphocytes from the elderly
Horgan et al., Ann Surg 1994 (Burns) : Expression and function of IL-2R were determined by monoclonal antibodies to the p55 and p75 chains of the IL-2R, binding of fluorescein labeled IL-2, and response to exogenous recombinant IL-2
Toyooka et al., Int Immunol 1996 : Conversely, IL-2R was not induced by bm12 B cell stimulation in the presence of IL-2