Gene interactions and pathways from curated databases and text-mining
Immunity 1997, PMID: 9133424

STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction.

Takeshita, T; Arita, T; Higuchi, M; Asao, H; Endo, K; Kuroda, H; Tanaka, N; Murata, K; Ishii, N; Sugamura, K

We previously identified a putative signal transducing adaptor molecule, named STAM, that contains an Src homology 3 (SH3) domain and immunoreceptor tyrosine-based activation motif (ITAM). In this report, we demonstrate the functional significance of STAM in cytokine-mediated signal transduction. STAM is associated with Jak3 and Jak2 tyrosine kinases via its ITAM region and phosphorylated by Jak3 and Jak2 upon stimulation with IL-2 and GM-CSF, respectively. An SH3 deletion mutant of STAM confers a dominant-negative effect on DNA synthesis mediated by IL-2 and GM-CSF. Furthermore, the wild-type STAM, but not STAM mutants deleted of SH3 and ITAM, significantly enhances c-myc induction mediated by IL-2 and GM-CSF. These results strongly implicate STAM in the signaling pathways for cell growth and c-myc induction immediately downstream of the Jaks associated with the cytokine receptors.

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Text Mining Data

STAM → GM-CSF: " STAM is associated with Jak3 and Jak2 tyrosine kinases via its ITAM region and phosphorylated by Jak3 and Jak2 upon stimulation with IL-2 and GM-CSF , respectively "

STAM → IL-2: " STAM is associated with Jak3 and Jak2 tyrosine kinases via its ITAM region and phosphorylated by Jak3 and Jak2 upon stimulation with IL-2 and GM-CSF, respectively "

Jak2 → GM-CSF: " STAM is associated with Jak3 and Jak2 tyrosine kinases via its ITAM region and phosphorylated by Jak3 and Jak2 upon stimulation with IL-2 and GM-CSF , respectively "

Jak2 → IL-2: " STAM is associated with Jak3 and Jak2 tyrosine kinases via its ITAM region and phosphorylated by Jak3 and Jak2 upon stimulation with IL-2 and GM-CSF, respectively "

Jak3 → GM-CSF: " STAM is associated with Jak3 and Jak2 tyrosine kinases via its ITAM region and phosphorylated by Jak3 and Jak2 upon stimulation with IL-2 and GM-CSF , respectively "

Jak3 → IL-2: " STAM is associated with Jak3 and Jak2 tyrosine kinases via its ITAM region and phosphorylated by Jak3 and Jak2 upon stimulation with IL-2 and GM-CSF, respectively "

Manually curated Databases

  • IRef Biogrid Interaction: STAM — JAK3 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: STAM — JAK2 (direct interaction, enzymatic study)
  • IRef Biogrid Interaction: STAM — JAK2 (physical association, affinity chromatography technology)
  • IRef Hprd Interaction: STAM — JAK2 (in vivo)
  • IRef Hprd Interaction: STAM — JAK1 (in vivo)
  • IRef Ophid Interaction: STAM — JAK2 (aggregation, confirmational text mining)
  • NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/STAM1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-STAM2_STAM) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) (modification, collaborate)
    Evidence: mutant phenotype, physical interaction
  • NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/STAM1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-STAM2_STAM) → STAM1-2 (STAM2/STAM) (modification, collaborate)
    Evidence: mutant phenotype, physical interaction
  • NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → STAM1-2 (STAM2/STAM) (modification, collaborate)
    Evidence: mutant phenotype, physical interaction
In total, 46 gene pairs are associated to this article in curated databases