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PPP2CA — TP53

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: PPP2CA — TP53 Zhao et al., Mol Cancer Res 2003*
• IRef Bind_translation Interaction: PPP2CA — TP53 (affinity chromatography technology) Zhao et al., Mol Cancer Res 2003*
• IRef Hprd Interaction: TP53 — PPP2CA (in vitro) Zhao et al., Mol Cancer Res 2003*
• IRef Intact Interaction: Complex of 244 proteins (association, pull down) Komarova et al., Mol Cell Proteomics 2011
• IRef Intact Interaction: Complex of MDM2-PPP2CA-PPP2R5C-TP53 (association, anti bait coimmunoprecipitation) Shouse et al., Oncogene 2011*
• IRef Intact Interaction: Complex of PPP2R5C-TP53-PPP2CA (association, anti tag coimmunoprecipitation) Shouse et al., Oncogene 2011*
• IRef Ophid Interaction: PPP2CA — TP53 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Okamoto et al., Mol Cell 2002 : Thus, our data suggest that cyclin G recruits PP2A in order to modulate the phosphorylation of Mdm2 and thereby to regulate both Mdm2 and p53
Messner et al., J Cell Biochem 2006 : Inhibition of PP2A , but not PP5, mediates p53 activation by low levels of okadaic acid in rat liver epithelial cells
Gwinn et al., Mol Cell 2013 : In this issue of Molecular Cell, Reid et al. ( 2013 ) show that glutamine withdrawal causes PP2A mediated activation of p53 through its regulator EDD, linking levels of a critical metabolite to an important regulator of cell survival and proliferation