Mol Cell 2002,
PMID: 11983168
Okamoto, Koji; Li, Hongyun; Jensen, Michael R; Zhang, Tingting; Taya, Yoichi; Thorgeirsson, Snorri S; Prives, Carol
The function of cyclin G, a commonly induced p53 target, has remained elusive. We show that cyclin G forms a quaternary complex in vivo and in vitro with enzymatically active phosphatase 2A (PP2A) holoenzymes containing B' subunits. Interestingly, cyclin G also binds in vivo and in vitro to Mdm2 and markedly stimulates the ability of PP2A to dephosphorylate Mdm2 at T216. Consistent with these data, cyclin G null cells have both Mdm2 that is hyperphosphorylated at T216 and markedly higher levels of p53 protein when compared to wild-type cells. Cyclin G expression also results in reduced phosphorylation of human Hdm2 at S166. Thus, our data suggest that cyclin G recruits PP2A in order to modulate the phosphorylation of Mdm2 and thereby to regulate both Mdm2 and p53.
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Text Mining Data
Hdm2 ⊣ Cyclin: "
Cyclin G expression also
results in reduced phosphorylation of human
Hdm2 at S166
"
p53 — Mdm2: "
Thus, our data suggest that cyclin G recruits PP2A in order to modulate the phosphorylation of Mdm2 and thereby to regulate both Mdm2 and p53
"
p53 — PP2A: "
Thus, our data suggest that cyclin G recruits PP2A in order to modulate the phosphorylation of Mdm2 and thereby to regulate both Mdm2 and p53
"
Mdm2 — PP2A: "
Thus, our data suggest that cyclin G recruits PP2A in order to modulate the phosphorylation of Mdm2 and thereby to regulate both Mdm2 and p53
"
Manually curated Databases
-
IRef Biogrid Interaction:
PYGM
—
PPP2R5A
(direct interaction, enzymatic study)
-
NCI Pathway Database p53 pathway:
Cyclin G1/PP2A-Bprime complex (PPP2CA-PPP2R4-CCNG1)
→
PP2A-Bprime complex (PPP2CA-PPP2R4)
(modification, collaborate)
Evidence: physical interaction
-
NCI Pathway Database p53 pathway:
Cyclin G1/PP2A-Bprime complex (PPP2CA-PPP2R4-CCNG1)
→
Cyclin G1 (CCNG1)
(modification, collaborate)
Evidence: physical interaction
-
NCI Pathway Database p53 pathway:
PP2A-Bprime complex (PPP2CA-PPP2R4)
→
Cyclin G1 (CCNG1)
(modification, collaborate)
Evidence: physical interaction
In total, 7 gene pairs are associated to this article in curated databases