Gene interactions and pathways from curated databases and text-mining
Mol Cell 2002, PMID: 11983168

Cyclin G recruits PP2A to dephosphorylate Mdm2.

Okamoto, Koji; Li, Hongyun; Jensen, Michael R; Zhang, Tingting; Taya, Yoichi; Thorgeirsson, Snorri S; Prives, Carol

The function of cyclin G, a commonly induced p53 target, has remained elusive. We show that cyclin G forms a quaternary complex in vivo and in vitro with enzymatically active phosphatase 2A (PP2A) holoenzymes containing B' subunits. Interestingly, cyclin G also binds in vivo and in vitro to Mdm2 and markedly stimulates the ability of PP2A to dephosphorylate Mdm2 at T216. Consistent with these data, cyclin G null cells have both Mdm2 that is hyperphosphorylated at T216 and markedly higher levels of p53 protein when compared to wild-type cells. Cyclin G expression also results in reduced phosphorylation of human Hdm2 at S166. Thus, our data suggest that cyclin G recruits PP2A in order to modulate the phosphorylation of Mdm2 and thereby to regulate both Mdm2 and p53.

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Text Mining Data

Hdm2 ⊣ Cyclin: " Cyclin G expression also results in reduced phosphorylation of human Hdm2 at S166 "

p53 — Mdm2: " Thus, our data suggest that cyclin G recruits PP2A in order to modulate the phosphorylation of Mdm2 and thereby to regulate both Mdm2 and p53 "

p53 — PP2A: " Thus, our data suggest that cyclin G recruits PP2A in order to modulate the phosphorylation of Mdm2 and thereby to regulate both Mdm2 and p53 "

Mdm2 — PP2A: " Thus, our data suggest that cyclin G recruits PP2A in order to modulate the phosphorylation of Mdm2 and thereby to regulate both Mdm2 and p53 "

Manually curated Databases

  • IRef Biogrid Interaction: PYGM — PPP2R5A (direct interaction, enzymatic study)
  • NCI Pathway Database p53 pathway: Cyclin G1/PP2A-Bprime complex (PPP2CA-PPP2R4-CCNG1) → PP2A-Bprime complex (PPP2CA-PPP2R4) (modification, collaborate)
    Evidence: physical interaction
  • NCI Pathway Database p53 pathway: Cyclin G1/PP2A-Bprime complex (PPP2CA-PPP2R4-CCNG1) → Cyclin G1 (CCNG1) (modification, collaborate)
    Evidence: physical interaction
  • NCI Pathway Database p53 pathway: PP2A-Bprime complex (PPP2CA-PPP2R4) → Cyclin G1 (CCNG1) (modification, collaborate)
    Evidence: physical interaction
In total, 7 gene pairs are associated to this article in curated databases