Gene interactions and pathways from curated databases and text-mining

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HMOX1 — NOS3

Text-mined interactions from Literome

Datta et al., J Am Soc Nephrol 1999 (Glomerulonephritis...) : Heme oxygenase-1 induction attenuates inducible nitric oxide synthase expression and proteinuria in glomerulonephritis
Coito et al., Transplantation 2002 (Obesity...) : Heme oxygenase-1 gene transfer inhibits inducible nitric oxide synthase expression and protects genetically fat Zucker rat livers from ischemia-reperfusion injury ... HO-1 gene transfer significantly prolongs survival of steatotic orthotopic liver transplants, depresses macrophage infiltration, suppresses local expression of inducible nitric oxide synthase , and modulates pro- and antiapoptotic pathways
Vicente et al., J Pharmacol Exp Ther 2003 (Inflammation) : Up-regulation of HO-1 by hemin administration resulted in inhibition of nitric-oxide synthase-2 activity, cellular infiltration into the air pouch exudate, and plasmatic exudation
Ling et al., Hepatology 2004 (Hepatopulmonary Syndrome) : Endothelin-1 (ET-1) stimulation of endothelial nitric oxide synthase (eNOS) via pulmonary endothelial endothelin B ( ET ( B ) ) receptors and pulmonary intravascular macrophage accumulation with expression of inducible nitric oxide synthase (iNOS) and heme oxygenase-1 (HO-1) are implicated in experimental hepatopulmonary syndrome (HPS) after common bile duct ligation ( CBDL )
Yang et al., J Biomed Sci 2004 : Heme oxygenase-1 attenuates interleukin-1beta induced nitric oxide synthase expression in vascular smooth muscle cells
Maeshima et al., Biochem Pharmacol 2005 (Respiratory Distress Syndrome, Adult...) : HA pretreatment markedly induced HO-1 in pulmonary epithelial cells, and ameliorated the lung injury induced by HSR as judged by the improvement of histological changes, while it decreased TNF-alpha and inducible nitric oxide synthase gene expression, lung wet weight to dry weight ratio, and myeloperoxidase activity
Datta et al., Nephrol Dial Transplant 2006 (Disease Models, Animal...) : Regulatory effects of inducible nitric oxide synthase on cyclooxygenase-2 and heme oxygenase-1 expression in experimental glomerulonephritis
Ahmad et al., Cell Mol Biol Incl Cyto Enzymol 2005 (Diabetes Mellitus...) : Therefore, overexpression of HO-1 may mediate an increase in eNOS and a decrease in iNOS, potentially contributing to restoration of vascular responses in diabetic rats
Dulak et al., Endothelium : journal of endothelial cell research 2005 : Atorvastatin stimulated the expression of angiopoietin (Ang)-2 and moderately enhanced the expression of endothelial nitric oxide synthase (eNOS) , whereas heme oxygenase-1 (HO-1) was not significantly affected
Li et al., Life Sci 2007 (Disease Models, Animal) : Meanwhile, PCNA expression and ERK activation were augmented with decreased lung tissue CO and HO-1 protein production but increased lung tissue NO production and eNOS expression
Ashino et al., Mol Immunol 2008 : Negative feedback regulation of lipopolysaccharide induced inducible nitric oxide synthase gene expression by heme oxygenase-1 induction in macrophages
Kim et al., Biomed Pharmacother 2008 : Involvement of anti-inflammatory heme oxygenase-1 in the inhibitory effect of curcumin on the expression of pro-inflammatory inducible nitric oxide synthase in RAW264.7 macrophages
Choi et al., Gastroenterology 2008 (Diabetes Mellitus, Experimental...) : Induction of HO-1 by hemin decreased reactive oxygen species, rapidly restored Kit and neuronal nitric oxide synthase expression, and completely normalized gastric emptying in all mice
Kim et al., J Periodontol 2009 : The anti-inflammatory role of heme oxygenase-1 in lipopolysaccharide and cytokine stimulated inducible nitric oxide synthase and nitric oxide production in human periodontal ligament cells
Pi et al., J Periodontal Res 2010 : Heme oxygenase-1 mediates nicotine- and lipopolysaccharide induced expression of cyclooxygenase-2 and inducible nitric oxide synthase in human periodontal ligament cells
Kachadourian et al., Free Radic Biol Med 2011 : They have been reported to inhibit the synthesis of the inducible nitric oxide synthase and to induce the expression of heme oxygenase-1
Kil et al., Journal of clinical biochemistry and nutrition 2012 : Heme oxygenase-1 expression via activation of nuclear factor-erythroid 2-related factor 2 inhibits nitric oxide production and inducible nitric oxide synthase expression in activated macrophages