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HMOX1 — NOS3
Text-mined interactions from Literome
Datta et al., J Am Soc Nephrol 1999
(Glomerulonephritis...) :
Heme oxygenase-1 induction
attenuates inducible
nitric oxide synthase expression and proteinuria in glomerulonephritis
Coito et al., Transplantation 2002
(Obesity...) :
Heme oxygenase-1 gene transfer
inhibits inducible
nitric oxide synthase expression and protects genetically fat Zucker rat livers from ischemia-reperfusion injury ...
HO-1 gene transfer significantly prolongs survival of steatotic orthotopic liver transplants, depresses macrophage infiltration,
suppresses local expression of inducible
nitric oxide synthase , and modulates pro- and antiapoptotic pathways
Vicente et al., J Pharmacol Exp Ther 2003
(Inflammation) :
Up-regulation of
HO-1 by hemin administration resulted in
inhibition of
nitric-oxide synthase-2 activity, cellular infiltration into the air pouch exudate, and plasmatic exudation
Ling et al., Hepatology 2004
(Hepatopulmonary Syndrome) :
Endothelin-1 (ET-1)
stimulation of
endothelial nitric oxide synthase (eNOS) via pulmonary endothelial endothelin B ( ET ( B ) ) receptors and pulmonary intravascular macrophage accumulation with expression of inducible nitric oxide synthase (iNOS) and
heme oxygenase-1 (HO-1) are implicated in experimental hepatopulmonary syndrome (HPS) after common bile duct ligation ( CBDL )
Yang et al., J Biomed Sci 2004
:
Heme oxygenase-1 attenuates interleukin-1beta induced
nitric oxide synthase expression in vascular smooth muscle cells
Maeshima et al., Biochem Pharmacol 2005
(Respiratory Distress Syndrome, Adult...) :
HA pretreatment markedly
induced HO-1 in pulmonary epithelial cells, and ameliorated the lung injury induced by HSR as judged by the improvement of histological changes, while it decreased TNF-alpha and inducible
nitric oxide synthase gene expression, lung wet weight to dry weight ratio, and myeloperoxidase activity
Datta et al., Nephrol Dial Transplant 2006
(Disease Models, Animal...) :
Regulatory
effects of inducible
nitric oxide synthase on cyclooxygenase-2 and
heme oxygenase-1 expression in experimental glomerulonephritis
Ahmad et al., Cell Mol Biol Incl Cyto Enzymol 2005
(Diabetes Mellitus...) :
Therefore, overexpression of
HO-1 may
mediate an increase in
eNOS and a decrease in iNOS, potentially contributing to restoration of vascular responses in diabetic rats
Dulak et al., Endothelium : journal of endothelial cell research 2005
:
Atorvastatin stimulated the expression of angiopoietin (Ang)-2 and moderately
enhanced the expression of
endothelial nitric oxide synthase (eNOS) , whereas
heme oxygenase-1 (HO-1) was not significantly affected
Li et al., Life Sci 2007
(Disease Models, Animal) :
Meanwhile, PCNA expression and ERK activation were augmented with decreased lung tissue CO and
HO-1 protein production but
increased lung tissue NO production and
eNOS expression
Ashino et al., Mol Immunol 2008
:
Negative feedback
regulation of lipopolysaccharide induced inducible
nitric oxide synthase gene expression by
heme oxygenase-1 induction in macrophages
Kim et al., Biomed Pharmacother 2008
:
Involvement of anti-inflammatory
heme oxygenase-1 in the inhibitory effect of curcumin on the expression of pro-inflammatory inducible
nitric oxide synthase in RAW264.7 macrophages
Choi et al., Gastroenterology 2008
(Diabetes Mellitus, Experimental...) :
Induction of
HO-1 by hemin decreased reactive oxygen species, rapidly
restored Kit and neuronal
nitric oxide synthase expression, and completely normalized gastric emptying in all mice
Kim et al., J Periodontol 2009
:
The anti-inflammatory
role of
heme oxygenase-1 in lipopolysaccharide and cytokine stimulated inducible
nitric oxide synthase and nitric oxide production in human periodontal ligament cells
Pi et al., J Periodontal Res 2010
:
Heme oxygenase-1 mediates nicotine- and lipopolysaccharide induced expression of cyclooxygenase-2 and inducible
nitric oxide synthase in human periodontal ligament cells
Kachadourian et al., Free Radic Biol Med 2011
:
They have been reported to inhibit the synthesis of the inducible
nitric oxide synthase and to
induce the expression of
heme oxygenase-1
Kil et al., Journal of clinical biochemistry and nutrition 2012
:
Heme oxygenase-1 expression via activation of nuclear factor-erythroid 2-related factor 2
inhibits nitric oxide production and inducible
nitric oxide synthase expression in activated macrophages