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nitric oxide synthase → interleukin-1beta: " Heme oxygenase-1 attenuates interleukin-1beta induced nitric oxide synthase expression in vascular smooth muscle cells "
inducible nitric oxide synthase (iNOS) → interleukin-1beta (IL-1beta): " To characterize the role of HO-1 in the vascular inflammatory response, we examined the effect of HO-1 on the expression of inducible nitric oxide synthase (iNOS) induced by interleukin-1beta (IL-1beta) in rat vascular smooth muscle cells ( VSMCs ) "
inducible nitric oxide synthase (iNOS) — HO-1: " To characterize the role of HO-1 in the vascular inflammatory response, we examined the effect of HO-1 on the expression of inducible nitric oxide synthase (iNOS) induced by interleukin-1beta (IL-1beta) in rat vascular smooth muscle cells ( VSMCs ) "
iNOS ⊣ HO-1: " Western blot analysis demonstrated that IL-1beta induced iNOS expression was significantly reduced by hemin cotreatment or adenovirus mediated HO-1 gene transfer "
iNOS → IL-1beta: " Western blot analysis demonstrated that IL-1beta induced iNOS expression was significantly reduced by hemin cotreatment or adenovirus mediated HO-1 gene transfer "
iNOS ⊣ HO-1: " Scavenging carbon monoxide ( CO ), one of the by-products of heme degradation by HO-1, significantly attenuated HO-1 mediated suppression of iNOS gene induction as revealed by Northern blot analysis "
iNOS → IL-1beta: " Exposure of cells to CO or a CO donor, the tricarbonyldichlororuthenium ( II ) dimer, also markedly inhibited IL-1beta induced iNOS expression "
iNOS → IL-1beta: " These data support the finding that HO-1 attenuates IL-1beta induced iNOS gene expression in VSMCs. CO appears to mediate the suppressive effect of HO-1, at least in part, through downregulating transcriptional activation of the iNOS gene via a cGMP dependent pathway "