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PARD3 — RAC1

Text-mined interactions from Literome

Nakanishi et al., Biol Chem 2004 : Nectins have five activities : ( 1 ) they show Ca2+ independent cell-cell adhesion activity by homo- and hetero-trans-interactions through their extracellular regions ; ( 2 ) they bind afadin, an actin filament ( F-actin) binding protein, through their cytoplasmic tails and are connected to the actin cytoskeleton ; ( 3 ) they induce activation of Cdc42 and Rac small G proteins through their cytoplasmic tails ; ( 4 ) they bind Par-3 , a cell polarity protein, through their cytoplasmic tails ; and ( 5 ) they heterophilically trans-interact with Necls, nectin-like molecules, through their extracellular regions
Nakayama et al., Dev Cell 2008 : PAR-3 directly interacts with Tiam1/Taim2 ( STEF ), Rac1-specific guanine nucleotide exchange factors, and forms a complex with aPKC-PAR-6-Cdc42*GTP, leading to Rac1 activation ... Knockdown of PAR-3 by small interfering RNA ( siRNA ) impaired cell migration, front-rear polarization, and PAR-3 mediated Rac1 activation, which were recovered with siRNA-resistant PAR-3, but not with the phospho-mimic PAR-3 mutant