Biol Chem 2004,
PMID: 15551862
Nakanishi, Hiroyuki; Takai, Yoshimi
Nectins are Ca2+-independent immunoglobulin (Ig)-like cell-cell adhesion molecules, which comprise a family consisting of four members. Nectins have five activities: (1) they show Ca2+-independent cell-cell adhesion activity by homo- and hetero-trans-interactions through their extracellular regions; (2) they bind afadin, an actin filament (F-actin)-binding protein, through their cytoplasmic tails and are connected to the actin cytoskeleton; (3) they induce activation of Cdc42 and Rac small G proteins through their cytoplasmic tails; (4) they bind Par-3, a cell polarity protein, through their cytoplasmic tails; and (5) they heterophilically trans-interact with Necls, nectin-like molecules, through their extracellular regions. Through these activities, nectins regulate a variety of cellular functions, including adhesion, migration, and polarization. Here we describe these activities and functions of nectins.
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Text Mining Data
Cdc42 → Par-3: "
Nectins have five activities : ( 1 ) they show Ca2+ independent cell-cell adhesion activity by homo- and hetero-trans-interactions through their extracellular regions ; ( 2 ) they bind afadin, an actin filament ( F-actin) binding protein, through their cytoplasmic tails and are connected to the actin cytoskeleton ; ( 3 ) they
induce activation of
Cdc42 and Rac small G proteins through their cytoplasmic tails ; ( 4 ) they bind
Par-3 , a cell polarity protein, through their cytoplasmic tails ; and ( 5 ) they heterophilically trans-interact with Necls, nectin-like molecules, through their extracellular regions
"
Rac → Par-3: "
Nectins have five activities : ( 1 ) they show Ca2+ independent cell-cell adhesion activity by homo- and hetero-trans-interactions through their extracellular regions ; ( 2 ) they bind afadin, an actin filament ( F-actin) binding protein, through their cytoplasmic tails and are connected to the actin cytoskeleton ; ( 3 ) they induce activation of Cdc42 and Rac small G proteins through their cytoplasmic tails ; ( 4 ) they bind Par-3 , a cell polarity protein, through their cytoplasmic tails ; and ( 5 ) they heterophilically trans-interact with Necls, nectin-like molecules, through their extracellular regions
"
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