Gene interactions and pathways from curated databases and text-mining

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IL12A — IL12RB1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Wu et al., Eur J Immunol 2000 : Using an antibody specific for the human IL-12Rbeta2 subunit, the effect of IFN-gamma, IFN-alpha, IL-12 and IL-2 on the regulation of IL-12R expression and IL-12 responsiveness of human T and NK cells was assessed
Nagayama et al., J Immunol 2000 : IL-12 also induced tyrosine phosphorylation of IL-12Rbeta1 as well as recruitment of several tyrosine phosphorylated proteins to IL-12Rbeta1 in DCs and Con A blasts
Okazawa et al., Am J Gastroenterol 2002 (Crohn Disease...) : The functional activity of IL- 12 and IL-18 was assessed by the effect of recombinant IL-12 and recombinant IL-18 on interferon-gamma production, the proliferative response, and the induction of IL-2R, IL-12R , and IL-18R of LPLs
Hoeve et al., Eur J Immunol 2003 : We have previously shown that human IL-12Rbeta1-deficiency leads to impaired IL-12 responsiveness and unusual susceptibility to infections due to mycobacteria and salmonellae ... Thus, IL-12Rbeta1-deficiency may impair both IL-12- and IL-23 signaling, and both may contribute to the immunological phenotypes
Reddy et al., Cell Immunol 2007 : CNTO 1275 inhibited upregulation of CLA, IL-12R , IL-2Ralpha and CD40L expression and also inhibited IL-12- and IL-23 induced IFN-gamma, IL-17A, tumor necrosis factor (TNF)-alpha, IL-2, and IL-10 secretion
Fahey et al., J Cell Mol Med 2007 (Multiple Sclerosis) : We report that curcumin decreases IL-12 induced STAT4 phosphorylation, IFN-gamma production, and IL-12 Rbeta1 and beta2 expression
Kano et al., Nat Immunol 2008 : Notably, the IRF1 dependent induction of IL-12Rbeta1 was essential for IFN-gamma-IL-12 signaling but was dispensable for IL-23-IL-17 signaling
Naume et al., Cytokine 1993 : IL-12 enhanced the IL-12 receptor (R) expression and IL-4R expression in the CD56+ NK cells ... The increased IL-4R expression induced by IL-12 and the increased IL-12R expression induced by IL-4 may explain the synergistic proliferative activity detected in response to IL-12 and IL-4
Presky et al., Ann N Y Acad Sci 1996 : Mouse IL-12 p40 subunit homodimer ( mo ( p40 ) 2 ) blocked 125I-huIL-12 binding to human IL-12R beta 1 , but did not inhibit binding to human IL-12R beta 2
Wu et al., J Immunol 1997 : To determine the role of IL-12Rbeta1 in mediating the biologic functions of IL-12 in mice, we have generated IL-12Rbeta1-deficient ( IL-12Rbeta1 ( -/- ) ) mice by targeted mutation in ES cells
Jones et al., Infect Immun 1998 (Disease Models, Animal...) : Neutralizing IL-4 and the administration of exogenous IL-12 upregulate IL-12R expression in BALB/c mice, while the neutralization of IL-12 in C3H mice blocks increased IL-12 receptor expression
Fujimiya et al., Clin Cancer Res 1997 (Brain Neoplasms...) : Thus, the increased expression of the IL-2Rbeta is critical for the synergistic activation of gammadelta T cells by IL-12 plus IL-2 ; it is also probable that at least the low-affinity IL-12R contributes to the activation of gammadelta T cells mediated by either IL-12 alone or IL-12 plus IL-2
Hyodo et al., J Immunol 1999 : These data suggested that NK cells develop and express IL-12R and IL-18R in the absence of IL-12 or IL-18, and that both IL-18 and IL-12 directly and independently augment perforin mediated cytotoxic activity of NK cells