◀ Back to RAC1
PLCG1 — RAC1
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
PLCG1
→
RAC1
(indirect_complex)
Tybulewicz et al., Immunol Rev 2003, Bos et al., Cell 2007
-
Reactome Reaction:
PLCG1
→
RAC1
(reaction)
Abe et al., J Biol Chem 2000, Zeng et al., Mol Cell Biol 2000, Chong et al., J Biol Chem 2001, Parrini et al., Mol Cell 2002, Tybulewicz et al., Immunol Rev 2003, Bos et al., Cell 2007
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Piechulek et al., J Biol Chem 2005
:
PLCgamma(2), but not
PLCgamma(1) , was markedly
activated in intact cells by constitutively active
Rac1 ( G12V ), Rac2 ( G12V ), and Rac3 ( G12V ) but not by Cdc42 ( G12V ) and RhoA ( G14V )
Choi et al., Cell Signal 2007
:
Interestingly,
PLC-gamma1 potentiated the activations of
Rac , thus integrin induced lamellipodia formation was up-regulated
Jones et al., Mol Cell Biol 2007
:
Furthermore, siRNA depletion of
PLCgamma1 , beta-Pix, or GIT1
inhibited Cdc42 and
Rac1 activation, while constitutively active forms of Cdc42 or Rac1, but not RhoA, were able to rescue the elongation of these cells ... As a component of this complex,
PLCgamma1 is also
involved in the activation of Cdc42 and
Rac1
Sala et al., Cancer Res 2008
(Breast Neoplasms...) :
In this study, we show that down-regulation of
PLCgamma1 expression severely
impairs activation of the small GTP binding protein
Rac and cell invasion in breast cancer cell lines and U87 in vitro
Ren et al., Cell Physiol Biochem 2012
:
In addition, inhibition of Src with its selective inhibitor PP2 and shRNA targeted to Src blocked Rac1 signal activation ( p < 0.05 for each ), but inhibition of the activity of
PLC?1 did not
affect the phosphorylation and activation levels of
Rac1 under conditions of periodic mechanical stress