The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008].
This track shows known protein-coding and non-protein-coding genes
for organisms other than dog, taken from the NCBI RNA reference
sequences collection (RefSeq). The data underlying this track are
Display Conventions and Configuration
This track follows the display conventions for
The color shading indicates the level of review the RefSeq record has
undergone: predicted (light), provisional (medium), reviewed (dark).
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To display codon colors, select the genomic codons option from the
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The RNAs were aligned against the dog genome using blat; those
with an alignment of less than 15% were discarded. When a single RNA aligned
in multiple places, the alignment having the highest base identity was
identified. Only alignments having a base identity level within 0.5% of
the best and at least 25% base identity with the genomic sequence were kept.
This track was produced at UCSC from RNA sequence data
generated by scientists worldwide and curated by the
NCBI RefSeq project.
BLAT--the BLAST-like alignment tool.
Genome Res. 2002 Apr;12(4):656-64.
PMID: 11932250; PMC: PMC187518
Pruitt KD, Brown GR, Hiatt SM, Thibaud-Nissen F, Astashyn A, Ermolaeva O, Farrell CM, Hart J,
Landrum MJ, McGarvey KM et al.
RefSeq: an update on mammalian reference sequences.
Nucleic Acids Res. 2014 Jan;42(Database issue):D756-63.
PMID: 24259432; PMC: PMC3965018
Pruitt KD, Tatusova T, Maglott DR.
NCBI Reference Sequence (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins.
Nucleic Acids Res. 2005 Jan 1;33(Database issue):D501-4.
PMID: 15608248; PMC: PMC539979