This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. Mice lacking this gene exhibit impaired development of organs, musculature and the skeleton, including absent and abnormally developed teeth, and neonatal lethality. Mutations in the human gene are associated with selective tooth agenesis-3. [provided by RefSeq, Sep 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
This track shows known protein-coding and non-protein-coding genes
for organisms other than marmoset, taken from the NCBI RNA reference
sequences collection (RefSeq). The data underlying this track are
Display Conventions and Configuration
This track follows the display conventions for
The color shading indicates the level of review the RefSeq record has
undergone: predicted (light), provisional (medium), reviewed (dark).
The item labels and display colors of features within this track can be
configured through the controls at the top of the track description page.
- Label: By default, items are labeled by gene name. Click the
appropriate Label option to display the accession name instead of the gene
name, show both the gene and accession names, or turn off the label
- Codon coloring: This track contains an optional codon coloring
feature that allows users to quickly validate and compare gene predictions.
To display codon colors, select the genomic codons option from the
Color track by codons pull-down menu. For more information about
this feature, go to the
Coloring Gene Predictions and Annotations by Codon page.
- Hide non-coding genes: By default, both the protein-coding and
non-protein-coding genes are displayed. If you wish to see only the coding
genes, click this box.
The RNAs were aligned against the marmoset genome using blat; those
with an alignment of less than 15% were discarded. When a single RNA aligned
in multiple places, the alignment having the highest base identity was
identified. Only alignments having a base identity level within 0.5% of
the best and at least 25% base identity with the genomic sequence were kept.
This track was produced at UCSC from RNA sequence data
generated by scientists worldwide and curated by the
NCBI RefSeq project.
BLAT--the BLAST-like alignment tool.
Genome Res. 2002 Apr;12(4):656-64.
PMID: 11932250; PMC: PMC187518
Pruitt KD, Brown GR, Hiatt SM, Thibaud-Nissen F, Astashyn A, Ermolaeva O, Farrell CM, Hart J,
Landrum MJ, McGarvey KM et al.
RefSeq: an update on mammalian reference sequences.
Nucleic Acids Res. 2014 Jan;42(Database issue):D756-63.
PMID: 24259432; PMC: PMC3965018
Pruitt KD, Tatusova T, Maglott DR.
NCBI Reference Sequence (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins.
Nucleic Acids Res. 2005 Jan 1;33(Database issue):D501-4.
PMID: 15608248; PMC: PMC539979