Mutations that confer drug resistance (Anna Niewiadomska, BV-BRC) (F479L)
 
Mutation: F479L
Position: NC_045512v2:14878-14880
Genomic Size: 3
View DNA for this feature (wuhCor1/SARS-CoV-2)

Reference genome nucleotidesTTT
Mutated nucleotides-
DescriptionConfers resistance (2.4x) in vitro to remdesivir [coordinates mapped from reported F476L in murine hepatitis virus model experiment to SARS-CoV-2].https://people.ucalgary.ca/~gordonp/RdRp:F479L.html#remdesivir_failure
ReferencesAgostini et al. (2018)

Mutation: F479L
Position: NC_045512v2:14878-14880
Genomic Size: 3
View DNA for this feature (wuhCor1/SARS-CoV-2)

Reference genome nucleotides
Mutated nucleotidesnd
Description
ReferencesAgostini et al. (2018)
View table schema

Go to Drug Resistance Mutations track controls

Data last updated at UCSC: 2022-07-01 11:52:39

Description

This track lists amino acid mutations that are known to confer drug resistance against Remdesivir, Sotrovimab, and Nirmatrelvir (Paxlovid). They were sourced with permission from Paul Gordon's website at the University of Calgary and Anna Niewiadomska from the J. Craig Venter Institute, manually input by Max Haeussler.

Display Conventions

Mutations are highlighted on the reference genome. Click or mouse over the mutations to show the full description.

Data Access

The data can be explored interactively with the Table Browser or the Data Integrator. For automated analysis, the genome annotation is stored in a bigBed file that can be downloaded from the download server or the API.

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Credits

Thanks to Anna Niewiadomska from the BV-BRC team at the J. Craig Venter Institute for converting these to coordinates.