Mutations that confer drug resistance (Anna Niewiadomska, BV-BRC) (L50F+E166V+L167F)
 
Mutation: L50F+E166V+L167F
Position: NC_045512v2:10553-10555
Genomic Size: 3
View DNA for this feature (wuhCor1/SARS-CoV-2)

Reference genome nucleotidesnd
Mutated nucleotidesnd
Description> 20x increase in EC50 values for ALG-097161, nirmatrelvir (PF-07321332) and PF-00835231
Referenceshttps://www.biorxiv.org/content/10.1101/2022.06.07.495116v1.full

Mutation: L50F+E166V+L167F
Position: NC_045512v2:10553-10555
Genomic Size: 3
View DNA for this feature (wuhCor1/SARS-CoV-2)

Reference genome nucleotidesnd
Mutated nucleotidesnd
Description> 20x increase in EC50 values for ALG-097161, nirmatrelvir (PF-07321332) and PF-00835231
Referenceshttps://www.biorxiv.org/content/10.1101/2022.06.07.495116v1.full
View table schema

Go to Drug Resistance Mutations track controls

Data last updated at UCSC: 2022-07-01 11:52:39

Description

This track lists amino acid mutations that are known to confer drug resistance against Remdesivir, Sotrovimab, and Nirmatrelvir (Paxlovid). They were sourced with permission from Paul Gordon's website at the University of Calgary and Anna Niewiadomska from the J. Craig Venter Institute, manually input by Max Haeussler.

Display Conventions

Mutations are highlighted on the reference genome. Click or mouse over the mutations to show the full description.

Data Access

The data can be explored interactively with the Table Browser or the Data Integrator. For automated analysis, the genome annotation is stored in a bigBed file that can be downloaded from the download server or the API.

Please refer to our mailing list archives for questions, or our Data Access FAQ for more information.

Credits

Thanks to Anna Niewiadomska from the BV-BRC team at the J. Craig Venter Institute for converting these to coordinates.