Mutant Mouse Bmp4 Eomes Foxa2 Gsc Hhex Lefty1 Lefty2 Lhx1 T Tdgf1 Wnt3. Click image to zoom in, drag or arrow keys to move. Caption is below.

source: MGI Reference: The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryo.
Year: 2002 Contributors: Norris D.P.,Brennan J.,Bikoff E.K.,Robertson E.J.,
Notes: AVE, anterior visceral endoderm; AS, anterior primitive streak; L1, lefty 1; L2 lefty 2.

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All Panes
Organism: Mus musculus Sex: n/a Stage: 6.5 day old embryo (Theiler 9a)
Body Part: whole Section Type: whole mount

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Pane B
Gene: Tdgf1 Probe: RNA GenBank: Strain: involves: 129S/SvEv * ICR
Genotype: Nodal^tm1.1Rob/Nodal^tm2Rob
Expression: embryo-ectoderm(+) regionally restricted

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Pane B
Gene: Tdgf1 Probe: RNA GenBank: Strain: ICR Genotype: wild type
Expression: embryo-ectoderm(+) regionally restricted

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Pane C
Gene: T Probe: RNA GenBank: NM_009309 Strain: ICR Genotype: wild type
Expression: embryo-ectoderm(+) regionally restricted, embryo-mesoderm(+), extraembryonic component(+) regionally restricted, primitive streak(+)

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Pane C
Gene: T Probe: RNA GenBank: NM_009309 Strain: involves: 129S/SvEv * ICR
Genotype: Nodal^tm1.1Rob/Nodal^tm2Rob
Expression: embryo-ectoderm(+) regionally restricted, embryo-mesoderm(+), extraembryonic component(+) regionally restricted, primitive streak(+)

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Pane D
Gene: Wnt3 Probe: RNA GenBank: Strain: ICR Genotype: wild type
Expression: embryo-ectoderm(+) regionally restricted, visceral endoderm(+) regionally restricted

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Pane D
Gene: Wnt3 Probe: RNA GenBank: Strain: involves: 129S/SvEv * ICR
Genotype: Nodal^tm1.1Rob/Nodal^tm2Rob
Expression: embryo-ectoderm(+) regionally restricted, visceral endoderm(+) regionally restricted

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Pane E
Gene: Foxa2 Probe: RNA GenBank: NM_010446
Strain: involves: 129S/SvEv * ICR Genotype: Nodal^tm1.1Rob/Nodal^tm2Rob
Expression: embryo-ectoderm(+), primitive streak(+) regionally restricted, visceral endoderm(+) regionally restricted

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Pane E
Gene: Foxa2 Probe: RNA GenBank: NM_010446 Strain: ICR Genotype: wild type
Expression: embryo-ectoderm(+), primitive streak(+) regionally restricted, visceral endoderm(+) regionally restricted

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Pane F
Gene: Hhex Probe: RNA GenBank: AK014111 Strain: ICR Genotype: wild type
Expression: definitive endoderm(+), visceral endoderm(+) regionally restricted

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Pane F
Gene: Hhex Probe: RNA GenBank: AK014111 Strain: involves: 129S/SvEv * ICR
Genotype: Nodal^tm1.1Rob/Nodal^tm2Rob
Expression: definitive endoderm(+), visceral endoderm(+) regionally restricted

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Pane G
Gene: Lhx1 Probe: RNA GenBank: NM_008498 Strain: ICR Genotype: wild type
Expression: definitive endoderm(+) regionally restricted, embryo-ectoderm(+) regionally restricted, embryo-mesoderm(+) regionally restricted, visceral endoderm(+) regionally restricted

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Pane G
Gene: Lhx1 Probe: RNA GenBank: NM_008498
Strain: involves: 129S/SvEv * ICR Genotype: Nodal^tm1.1Rob/Nodal^tm2Rob
Expression: definitive endoderm(+) regionally restricted, embryo-ectoderm(+) regionally restricted, embryo-mesoderm(+) regionally restricted, visceral endoderm(+) regionally restricted

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Pane H
Gene: Gsc Probe: RNA GenBank: Strain: involves: 129S/SvEv * ICR
Genotype: Nodal^tm1.1Rob/Nodal^tm2Rob
Expression: embryo-ectoderm(0.50) regionally restricted, primitive streak(+) regionally restricted, visceral endoderm(+) regionally restricted

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Pane H
Gene: Gsc Probe: RNA GenBank: Strain: ICR Genotype: wild type
Expression: embryo-ectoderm(0.50) regionally restricted, primitive streak(+) regionally restricted, visceral endoderm(+) regionally restricted

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Pane I
Gene: Lefty1 (purple), Lefty2 (purple) Probe: RNA, RNA GenBank: ,
Strain: ICR Genotype: wild type
Expression of Lefty2: embryo-ectoderm(+) regionally restricted, embryo-mesoderm(+)
Expression of Lefty1: visceral endoderm(+) regionally restricted

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Pane I
Gene: Lefty1 (purple), Lefty2 (purple) Probe: RNA, RNA GenBank: ,
Strain: involves: 129S/SvEv * ICR Genotype: Nodal^tm1.1Rob/Nodal^tm2Rob
Expression of Lefty2: embryo-ectoderm(+) regionally restricted, embryo-mesoderm(+)
Expression of Lefty1: visceral endoderm(+) regionally restricted

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Pane J
Gene: Eomes Probe: RNA GenBank: AB031037
Strain: involves: 129S/SvEv * ICR Genotype: Nodal^tm1.1Rob/Nodal^tm2Rob
Expression: embryo-ectoderm(+) regionally restricted, extraembryonic component(+) regionally restricted

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Pane J
Gene: Eomes Probe: RNA GenBank: AB031037 Strain: ICR Genotype: wild type
Expression: embryo-ectoderm(+) regionally restricted, extraembryonic component(+) regionally restricted

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Pane K
Gene: Bmp4 Probe: RNA GenBank: NM_007554
Strain: involves: 129S/SvEv * ICR Genotype: Nodal^tm1.1Rob/Nodal^tm2Rob
Expression: extraembryonic component-ectoderm(+)

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Pane K
Gene: Bmp4 Probe: RNA GenBank: NM_007554 Strain: ICR Genotype: wild type
Expression: extraembryonic component-ectoderm(+)

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Copyright: This image is from Norris DP, Development 2002;129():3455-68 and is displayed with the permission of The Company of Biologists Limited who owns the Copyright.
Acknowledgements: Thanks to the Gene Expression Database group at Mouse Genome Informatics (MGI) for collecting, annotating and sharing this image. The MGI images were last updated in VisiGene on March 28, 2006. Additional and more up to date annotations and images may be available directly at MGI.

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