This track shows the fixed (unchanging) transcript(s) associated with
Locus Reference Genomic (LRG) sequence.
sequences are manually curated, stable DNA sequences that surround a
locus (typically a gene) and provide an unchanging coordinate system
for reporting sequence variants. They are not necessarily identical
to the corresponding sequence in a particular reference genome
assembly (such as Dec. 2013 (GRCh38/hg38)), but can be mapped to each version of a
reference genome assembly in order to convert between the stable LRG
variant coordinates and the various assembly coordinates.
We import the data from the LRG database at the EBI.
The NCBI RefSeqGene database is almost identical to LRG,
but it may contain a few more sequences. See the NCBI documentation.
The LRG Regions track, in the Mapping and Sequencing Tracks section,
includes more information about the LRG including the HGNC gene symbol
for the gene at that locus, source of the LRG sequence, and summary of
differences between LRG sequence and the genome assembly.
LRG sequences are suggested by the community studying a locus (for example,
Locus-Specific Database curators, research laboratories, mutation consortia).
LRG curators then examine the submitted transcript as well as other known
transcripts at the locus, in the context of alignment and public expression
For more information on the selection and annotation process, see the
(Dalgleish, et al.) and (MacArthur, et al.).
This track was produced at UCSC using
LRG XML files.
collaborators for making these data available.
Dalgleish R, Flicek P, Cunningham F, Astashyn A, Tully RE, Proctor G, Chen Y, McLaren WM, Larsson P,
Vaughan BW et al.
Locus Reference Genomic sequences: an improved basis for describing human DNA variants.
Genome Med. 2010 Apr 15;2(4):24.
PMID: 20398331; PMC: PMC2873802
MacArthur JA, Morales J, Tully RE, Astashyn A, Gil L, Bruford EA, Larsson P, Flicek P, Dalgleish R,
Maglott DR et al.
Locus Reference Genomic: reference sequences for the reporting of clinically relevant sequence
Nucleic Acids Res. 2014 Jan;42(Database issue):D873-8.
PMID: 24285302; PMC: PMC3965024