The Genetic Association Database (GAD) is intended for use primarily by
medical scientists and other professionals concerned with genetic disorders,
by genetics researchers, and by advanced students in science
and medicine. While the GAD database is open to the public,
users seeking information about a personal medical or
genetic condition are urged to consult with a qualified
physician for diagnosis and for answers to personal questions.
These data are provided by the GAD
and do not represent any additional curation by UCSC.
After serving the scientific community for more than 10 years,
the Genetic Association Database (GAD) has been retired and all data is "frozen" as of 09/01/2014.
Genetic Association Database is an archive of human genetic
association studies of complex diseases and disorders. The goal
of the database is to allow the user to rapidly identify medically
relevant polymorphism from the large volume of polymorphism and
mutational data, in the context of standardized nomenclature.
If the track is displayed in "pack" or "full" mode,
mousing over an entry of this track will show a pop-up message listing all
In "full" mode, each feature is labeled with the associated disease
class code (as defined below).
| Disease Class|| Disease Class Code|
| AGING || AGE |
| CANCER || CAN |
| CARDIOVASCULAR || CARD |
| CHEMICAL DEPENDENCY || CHEM |
| DEVELOPMENTAL || DEV |
| HEMATOLOGICAL || HEM |
| IMMUNE || IMM |
| INFECTION || INF |
| METABOLIC || MET |
| MITOCHONDRIAL || MITO |
| NEUROLOGICAL || NEUR |
| NORMAL VARIATION || NV |
| OTHER || OTH |
| PHARMACOGENOMICS || PHARM |
| PSYCHIATRIC || PSY |
| RENAL || REN |
| REPRODUCTION || REP |
| UNKNOWN || UNK |
| VISION || VIS |
Study data are recorded in the context of official human gene
nomenclature with additional molecular reference numbers and links. The data
are gene-centered; that is, each record is based on a gene or marker.
For example, if a study investigated six genes for a particular disorder,
there will be six records. Gene information is standardized and annotated with
molecular information, enabling integration with other molecular and genomic
Data are added to GAD on a periodic
basis by the curator or investigators. A majority of the records in GAD
are extracted from the online
database, which is sponsored by the Centers for Disease Control and
Prevention. HuGE Navigator
provides access to a continuously updated, curated knowledge base of
gene-disease associations, meta-analyses, and related information on genes
and diseases extracted from NCBI PubMed. A gene-centered view is available via
For more information on this dataset, contact
Kevin G. Becker, PhD,
Yongqing Zhang, PhD, and John Garner, MS,
from the DNA Array Unit, NIA, NIH.
Becker KG, Barnes KC, Bright TJ, Wang AS.
The Genetic Association Database.
Nature Genetics 2004 May; 36(5):431-432.