Schema for Drug Resistance Mutations - Mutations that confer drug resistance (Anna Nieviadomska, BV-BRC)
  Database: wuhCor1    Primary Table: resist Data last updated: 2022-07-01
Big Bed File: /gbdb/wuhCor1/resist/resist.bb
Item Count: 29
Format description: Drug Resistance Sites
fieldexampledescription
chromNC_045512v2Reference sequence chromosome or scaffold
chromStart10113Start position in chromosome
chromEnd10116End position in chromosome
nameT21I+T304IRdRp mutation coordinates
score0Score (always 0)
strand.Strand (always .)
thickStart10113Start again
thickEnd10116End again
color0,0,0Color as r,g,b value
fromNucndReference genome nucleotides
toNucndMutated nucleotides
commentsmoderate nirmatrelvir resistanceDescription
urlshttps://www.biorxiv.org/content/10.1101/2022.06.06.494921v1.fullReferences

Sample Rows
 
chromchromStartchromEndnamescorestrandthickStartthickEndcolorfromNuctoNuccommentsurls
NC_045512v21011310116T21I+T304I0.10113101160,0,0ndndmoderate nirmatrelvir resistancehttps://www.biorxiv.org/content/10.1101/2022.06.06.494921v1.full
NC_045512v21020010203L50F+E166V0.10200102030,0,0ndnd175-fold nirmatrelvir resistance with long term treatment; 80-fold nirmatrelvir resistance with short term treatmenthttps://www.biorxiv.org/content/10.1101/2022.06.06.494921v1.full
NC_045512v21020010203L50F+E166V0.10200102030,0,0ndnd175-fold nirmatrelvir resistance with long term treatment; 80-fold nirmatrelvir resistance with short term treatmenthttps://www.biorxiv.org/content/10.1101/2022.06.06.494921v1.full
NC_045512v21020010203L50F+E166V+L167F0.10200102030,0,0ndnd> 20x increase in EC50 values for ALG-097161, nirmatrelvir (PF-07321332) and PF-00835231https://www.biorxiv.org/content/10.1101/2022.06.07.495116v1.full
NC_045512v21020010203L50F+A173V0.10200102030,0,0ndndmoderate nirmatrelvir resistancehttps://www.biorxiv.org/content/10.1101/2022.06.06.494921v1.full
NC_045512v21048310486S144M/F/A/G/Y0.10483104860,0,0nanacomparable enzymatic activity as the wild-type (kcat/Km  10-fold increase)https://www.biorxiv.org/content/10.1101/2022.06.28.497978v1
NC_045512v21054610549M165T0.10546105490,0,0nanacomparable enzymatic activity as the wild-type (kcat/Km  10-fold increase)https://www.biorxiv.org/content/10.1101/2022.06.28.497978v1
NC_045512v21054910552E166Q0.10549105520,0,0nanacomparable enzymatic activity as the wild-type (kcat/Km  10-fold increase)https://www.biorxiv.org/content/10.1101/2022.06.28.497978v1
NC_045512v21054910552E166V0.10549105520,0,0ndndHigh nirmatrelvir resistancehttps://www.biorxiv.org/content/10.1101/2022.06.06.494921v1.full
NC_045512v21054910552E166A0.10549105520,0,0ndndresistance to ALG-097161, nirmatrelvir (PF-07321332) and PF-00835231https://www.biorxiv.org/content/10.1101/2022.06.07.495116v1.full

Drug Resistance Mutations (resist) Track Description
 

Description

This track lists amino acid mutations that are known to confer drug resistance against Remdesivir, Sotrovimab, and Nirmatrelvir (Paxlovid). They were sourced with permission from Paul Gordon's website at the University of Calgary and Anna Niewiadomska from the J. Craig Venter Institute, manually input by Max Haeussler.

Display Conventions

Mutations are highlighted on the reference genome. Click or mouse over the mutations to show the full description.

Data Access

The data can be explored interactively with the Table Browser or the Data Integrator. For automated analysis, the genome annotation is stored in a bigBed file that can be downloaded from the download server or the API.

Please refer to our mailing list archives for questions, or our Data Access FAQ for more information.

Credits

Thanks to Anna Niewiadomska from the BV-BRC team at the J. Craig Venter Institute for converting these to coordinates.