Gene interactions and pathways from curated databases and text-mining

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RHOA — WNT5A

Text-mined interactions from Literome

Zhu et al., PloS one 2012 (Breast Neoplasms) : We showed here that Wnt5a activated Dvl2, Daam1 and RhoA , and promoted migration of breast cancer cells, which was, however, abolished by Secreted Frizzled related protein 2 ( sFRP2 ) pretreatment ... Dominant negative Dvl2 mutants or Dvl2 siRNA significantly decreased Wnt5a induced Daam1/RhoA activation and cell migration ... Ectopic expression of N-Daam1, a dominant negative mutant, or Daam1 siRNA remarkably inhibited Wnt5a induced RhoA activation, stress fiber formation and cell migration
Liu et al., Cell Signal 2013 (Stomach Neoplasms) : Additionally, GSK3ß siRNA remarkably inhibited Wnt5a induced RhoA activation, stress fiber formation and cell migration
Zhu et al., Cell Signal 2013 (Breast Neoplasms) : However, we found here that RhoA activation was not enhanced by Wnt5a in breast cancer cells MCF-7
Wang et al., PloS one 2013 : Instead of activating the canonical Wnt signal pathway in hDPCs, Wnt5a stimulation induced activation of the JNK signal in a RhoA dependent or independent manner