Graham et al., Cancer Res 2008
(Neoplasm Invasiveness...) :
Insulin-like growth factor-I dependent up-regulation of ZEB1 drives epithelial-to-mesenchymal transition in human prostate cancer cells ... In the present study, we investigated the role of insulin-like growth factor-I (IGF-I) in the regulation of ZEB1 during EMT associated with prostate tumor cell migration ... These results identify ZEB1 as a key transcriptional regulator of EMT in prostate cancer and suggest that the aberrant expression of ZEB1 in prostate cancer cells occurs in part in response to IGF-I stimulation
Ko et al., J Cell Physiol 2009
:
RNA interference mediated depletion of IGF-1 in epithelial cells prevented the effect of these cells on ZEB1 expression in fibroblasts