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GCG — IGF1
Text-mined interactions from Literome
Serri et al., Endocrinology 1992
:
We conclude that : 1 ) octreotide inhibits
IGF-I serum levels and hepatic gene expression in the hypox rat ; and 2 ) octreotide can
inhibit partially the direct effects of GH and
glucagon on hepatic IGF-I production
Kachra et al., Endocrinology 1991
:
To study the
role of GH and
glucagon in the regulation of
IGF-I and IGF-BP production, we examined IGF-I and IGF-BPs secreted by primary rat hepatocytes cultured in a serum-free medium ...
Glucagon ( 1 x 10 ( -8 ) M )
stimulated IGF-I secretion and IGF-BP secretion ...
Glucagon stimulated
IGF-I mRNA levels 1.8- to 2.0-fold, whereas bGH stimulated IGF-I mRNA levels 2.0- to 2.5-fold
Zvibel et al., Mol Cell Biol 1991
(Carcinoma, Hepatocellular...) :
Transcriptionally,
IGF II was
regulated by the additive effects of insulin,
glucagon , and growth hormone in combination with heparin ; TGF beta was regulated primarily by the synergistic effects of insulin and growth hormone in combination with heparin
Zhu et al., Invest Ophthalmol Vis Sci 2009
(Disease Models, Animal...) :
In eyes without lenses, both insulin and
IGF-1 speeded, and glucagon slowed, ocular elongation, but
glucagon and insulin each
increased the rate of thickening of the crystalline lens
Masumoto et al., Fukuoka Igaku Zasshi 1991
:
Conversely,
glucagon stimulated the production of
IGF-I at concentrations over 10 ( -8 ) M, but inhibited the production of albumin at concentrations over 10 ( -10 ) M. Dexamethasone stimulated the production of IGF-I at concentrations over 10 ( -7 ) M, but had no significant effects on the production of albumin
Kawai et al., Endocrinol Jpn 1990
:
Effects of
insulin-like growth factor-I on insulin and
glucagon release from isolated perfused rat pancreas
Kachra et al., Endocrinology 1994
:
In previous studies it was shown that bovine GH ( bGH ) and
glucagon , when individually added to primary rat hepatocyte cultures, modestly
stimulated IGF-I mRNA levels 1.8- to 2.5-fold, but when combined, synergized to stimulate IGF-I mRNA levels by 10- to 12-fold ... The
effect of
glucagon , mediated via the activation of adenylate cyclase, involves in part the posttranscriptional stabilization of
IGF-I mRNA levels
Hilding et al., J Clin Endocrinol Metab 1993
(Diabetes Mellitus, Type 1...) :
Glucagon stimulates
insulin-like growth factor binding protein-1 secretion in healthy subjects, patients with pituitary insufficiency, and patients with insulin dependent diabetes mellitus
Denver et al., J Endocrinol 1994
:
In contrast,
glucagon ( 0.1-100 nmol/l )
inhibited IGF-I production in a dose related manner ...
Glucagon ( 10 nmol/l ) also
inhibited IGF-I secretion stimulated by rGH ( 5 pmol/l ) and insulin ( 10 nmol/l ) ... Northern blot analysis of total RNA isolated from rat hepatocytes revealed that rGH ( 5 pmol/l ) elevated IGF-I mRNA levels, glucagon ( 10 nmol/l ) alone had no effect on this parameter, but
glucagon significantly
reduced IGF-I transcript accumulation in response to rGH
Dheen et al., Diabetologia 1996
:
These observations prompted us to investigate the
effects of glucose and
insulin-like growth factor-I (IGF-I) on insulin and
glucagon release by isolated islets from Tg and Wt mice
Acerini et al., Metabolism 1998
(Diabetes Mellitus, Type 1...) :
Effects of low-dose recombinant human
insulin-like growth factor-I on insulin sensitivity, growth hormone and
glucagon levels in young adults with insulin dependent diabetes mellitus