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FCGR1A — IFNG

Text-mined interactions from Literome

Stein et al., J Clin Invest 2000 : However, IFN-gamma enhanced FcgammaRI expression by H-131 monocytes and increased CRP binding
Keler et al., J Immunol 2000 : With the exception of IFN-gamma mediated enhancement of Fc gamma RI expression and Fc gamma RI gamma-chain complexes, the regulation of Fc gamma RI- or Fc alpha RI-mediated activity occurred without significant change in either receptor expression or total complexes with gamma subunit
Hetland et al., Hum Exp Toxicol 2000 : Phenotyping of U937 cells for complement receptors (CRs) and Fcgamma receptors ( FcgammaRs ) showed that interferon gamma (INFgamma) increased expression of FcgammaRI , CR3 ( CD11b/CD18 ) and CR4 ( CD11c/CD18 ) and that phorbol-12-myristate-13-acetate ( PMA ) increased expression of CR4
Beigier-Bompadre et al., Clin Diagn Lab Immunol 2001 : Considering the biological relevance of the regulation of FcgammaRI, we investigated the effect of FMLP on the overexpression of FcgammaRI induced by both IFN-gamma and IL-10 on human monocytes
Flesch et al., Vox Sang 2001 : PMN ingested these target cells only after induction of the FcgammaRI by interferon-gamma (IFN-gamma)
Woolhiser et al., Eur J Immunol 2001 : IgG dependent activation of human mast cells following up-regulation of FcgammaRI by IFN-gamma ... It has been reported that FcgammaRI is up-regulated on human mast cells ( huMC ) by IFN-gamma and aggregation of this receptor using mouse F ( ab ' ) ( 2 ) specific for receptor bound, mouse anti-CD64 F ( ab ' ) ( 2 ) results in activation
Aittomäki et al., Blood 2002 : The basal activity of the natural FcgammaRI promoter was strictly dependent on PU.1, and IFN-gamma induction required both PU.1 and Stat1
Beigier-Bompadre et al., Clin Exp Immunol 2003 (Tuberculosis, Pulmonary) : Although the prototypic formyl peptide N-formyl-methionyl-leucyl-phenylalanine ( FMLP ) is a well-known proinflammatory agonist, we have demonstrated previously that preincubation of monocytes with FMLP inhibited the up-regulation of FcgammaRI induced by IFN-gamma or IL-10 ... In conclusion, in this study we demonstrated the existence of two novel mechanisms that may contribute to the pathological effects generated by M. tuberculosis : the enhancement of FcgammaRI in response to IFN-gamma and IL-10, and the unresponsiveness to the anti-inflammatory effects induced by formyl peptides
Gehring et al., Infect Immun 2003 : The 19-kDa lipoprotein also inhibited IFN-gamma induced expression of Fc gamma RI
Nabbe et al., Am J Pathol 2003 (Arthritis, Experimental...) : FcgammaRI up-regulation induced by local adenoviral mediated interferon-gamma production aggravates chondrocyte death during immune complex mediated arthritis ... We now investigated whether local overexpression of IFN-gamma using an adenoviral vector is able to elevate cartilage destruction during experimental immune complex mediated arthritis ( ICA ) and to what extent this process is FcgammaRI mediated ... Local overexpression of IFN-gamma induced increased FcgammaRI mRNA levels in synovium
Reinisch et al., Clin Exp Immunol 2003 (Carcinoma, Renal Cell...) : No differences in IFN-gamma dependent CD64 and invariant chain expression, and IFN-gamma serum levels were observed among the response subgroups
Klebanoff et al., Blood 1992 : CD64 and gp91-phox mRNA were generally increased by IFN-gamma to a level greater than that of freshly isolated neutrophils
Wilson et al., Proc Natl Acad Sci U S A 1992 : Recently, Pearse et al. [ Pearse, R.N., Feinman, R. & Ravetch, J. V. ( 1991 ) Proc. Natl. Acad. Sci. USA 88, 11305-11309 ] defined within the promoter region of the Fc gamma RI gene an element, the gamma response region, which was necessary for IFN-gamma induced enhancement of Fc gamma RI
Capsoni et al., Clin Exp Immunol 1992 (HIV Infections) : Interferon-gamma (IFN-gamma) induces de novo expression of IgG Fc receptor type I (FcRI) on neutrophils and significantly raises the level of these receptors on monocytes
Comber et al., Cell Immunol 1992 : In U937 cells, IFN-gamma increased Fc gamma RI mRNA levels 7.5-fold
te Velde et al., J Immunol 1992 : Here, we demonstrate that in contrast to the down-regulation of MHC class II Ag expression, IL-10 stimulates Fc gamma RI expression on human monocytes comparable to the levels of Fc gamma RI expression induced by IFN-gamma
Aittomäki et al., Int Immunol 2004 : PU.1 was required for both the basal activity and for the IFN-gamma induced FcgammaRI promoter activation, while Stat1 alone could not initiate transcription
Woolhiser et al., Clin Immunol 2004 : Human mast cells ( huMC ) increase surface expression of FcgammaRI ( CD64 ) in response to IFNgamma
Beekman et al., Proc Natl Acad Sci U S A 2004 : PPL and FcgammaRI colocalized at the plasma membrane in monocytes and cell transfectants, and both were up-regulated by IFN-gamma
Isturiz et al., Medicina (B Aires) 2004 (Inflammation) : Moreover, FMLP inhibited interferon gamma (IFN-gamma) induced FcgammaRI expression and IC downregulate class II molecules of the major histocompatibility complex on monocytes
Park et al., Int J Tuberc Lung Dis 2004 (Disease Susceptibility...) : IFN-gamma stimulated an increase in the expression of HLA-DR and CD64 on monocytes of both controls and patients ; the rate of increase in expression was the same in both groups
Holl et al., Blood 2006 (HIV Infections) : After induction of FcgammaRI expression on iMDDCs by IFN-gamma , an augmentation of the HIV-inhibitory activity of IgG, related to the expression of FcgammaRI, was observed
Kårehed et al., Mol Immunol 2007 : In this report we use IFN-gamma induced upregulation of the high affinity receptor for IgG ( FcgammaRI/CD64 ) in the human monocytic cell line U-937 as a model for monocytic activation ... Silencing of PKR expression by siRNA or inhibition of PKR by 2-aminopurine ( 2-AP ) potently blocks the IFN-gamma induced transcriptional activation of the FcgammaRI promoter ... We find that the serine 727 phosphorylation of Stat1, required for full IFN-gamma induced FcgammaRI promoter activity, is dependent on PKR ... We further show that IFN-gamma induction of FcgammaRI upregulation is dependent on the NFkappaB pathway, as evidenced by inhibition of NFkappaB using a phosphorylation defective IkappaBalpha ( S32A/S36A ) mutant, or inhibiting the IkappaB-kinase (IKK) by treatment with BMS345541 ... Our results suggest that IFN-gamma induced increase of FcgammaRI expression requires the integration of two signalling events : PKR dependent Stat1 serine 727 phosphorylation, and activation of NFkappaB
Nguyen et al., Cell Mol Biol Incl Cyto Enzymol 2006 (Leukemia, Lymphocytic, Chronic, B-Cell) : Enhancement of Fc-gammaRI and HLA-DR on monocytes by interferon-gamma , but not by all-trans retinoic acid, was accompanied by up-regulation of surface matrix metalloproteinase-9
Boekhoudt et al., J Leukoc Biol 2007 : These data suggest a mechanism of IC-mediated inhibition of IFN-gamma signaling, which requires the ITAM containing FcgammaRI , as well as the ITIM dependent phosphatase SHP-1, ultimately resulting in the suppression of STAT1 phosphorylation
Shpacovitch et al., Exp Dermatol 2007 (Sepsis) : Synthetic PAR(2) agonist also enhanced protective interferon (IFN)gamma induced FcgammaRI expression at neutrophil cell surface
Ohta et al., Cell 1991 : In the absence of IgG, all Fc gamma RI molecules in undifferentiated cells of myeloid line U937 bound to ABP over a 9-fold range of Fc gamma RI expression induced by human IFN-gamma
Nambu et al., Cell Immunol 1991 (Leukemia, Eosinophilic, Acute) : IFN-gamma induced Fc gamma RI expression, and Bt2 cAMP, which did not induce Fc gamma RI expression by itself, showed an additive effect on IFN-gamma induced Fc gamma RI expression
Quan et al., Neurosci Lett 2009 : Using quantitative real-time PCR we show that IFN-gamma induced a 4-fold increase in the mRNA level of FcgammaRI but did not induce changes in FcgammaRIIb expression
Erbe et al., Mol Immunol 1990 (Leukemia, Promyelocytic, Acute) : IFN-gamma dramatically up-regulated Fc gamma RI expression on all cells tested
Vaickus et al., Blood 1990 (Leukemia...) : ( 5 ) IFN-gamma induced granulocyte expression of CD64 , the IgG Fc receptor that binds murine IgG2a MoAbs
Cassatella et al., Biochem Biophys Res Commun 1990 : These results indicate that phagocytes ' Fc gamma R-I mRNA induction by IFN-gamma is regulated by different mechanisms depending on the target cells
Rossman et al., Cell Immunol 1989 : Interferon-gamma primarily stimulated Fc gamma RI , as determined both by reactivity with monoclonal antibody ( 227 +/- 26 % ) and by monomeric IgG ligand binding ( 350 +/- 151 % )
Graziano et al., J Immunol 1987 : Since Fc gamma RI is not detectable on untreated neutrophils and is induced by IFN-gamma on these cells, lysis of HC 32.2A by IFN-gamma activated neutrophils correlated with receptor induction
Paquette et al., Mol Immunol 1995 : Nuclear run-on analysis revealed that the rate of Fc gamma RI transcription was increased by IFN-gamma
Boltz-Nitulescu et al., J Leukoc Biol 1995 : On monocytes, the basal level and IFN-gamma induced Fc gamma RI/CD64 expression was down-regulated by calcitriol and IL-4
Politis et al., J Leukoc Biol 1993 : It is concluded that Fc gamma RI is induced by both IFN-alpha and IFN-gamma through distinct biochemical pathways, whereas IFN-gamma utilizes distinct pathways to induce the two macrophage activation markers, Ia antigen and Fc gamma RI
de Waal Malefyt et al., J Immunol 1993 : IFN-gamma could also partially prevent the IL-13 induced down-regulation of CD64 , but not that of CD32 and CD16
Feldman et al., J Immunol 1995 : IgG immune complexes inhibit IFN-gamma induced transcription of the Fc gamma RI gene in human monocytes by preventing the tyrosine phosphorylation of the p91 ( Stat1 ) transcription factor ... Because many genes, including MHC class II Ags, transcriptionally activated by IFN-gamma require the tyrosine phosphorylation of the transcription factor p91 ( Stat1 ), we examined whether IC could suppress IFN-gamma induced expression of the Fc gamma receptor I gene ( Fc gamma RI ) in human monocytes and whether this occurred through inhibition of p91 phosphorylation ... Therefore, culture of monocytes on IC inhibits IFN-gamma induced expression of the Fc gamma RI gene by preventing tyrosine phosphorylation of p91, probably by the associated inhibition of the tyrosine kinases Jak1 and Jak2
Lehmann et al., J Immunol 1994 : In mouse peritoneal macrophages, IL-4 and IL-10 influenced both basal and IFN-gamma induced expression of Fc gamma RI in opposite ways : IL-10 was stimulatory and IL-4 repressed Fc gamma RI expression
Gessl et al., Scand J Immunol 1994 : TNF-alpha, as well as interferon-gamma (IFN-gamma) or interleukin-6 (IL-6) had a significant up-regulating effect on U937 expression of Fc gamma RI/CD64
Pearse et al., Proc Natl Acad Sci U S A 1993 : Thus, these data demonstrate that the IFN-gamma activated 91-kDa protein is required for IFN-gamma induction of Fc gamma RI and suggest that an additional complex may be required for optimal expression and specificity
Sivo et al., J Immunol 1996 : Heat shock mimics glucocorticoid effects on IFN-gamma induced Fc gamma RI and Ia messenger RNA expression in mouse peritoneal macrophages ... In murine macrophages, glucocorticoids exert opposing effects on the IFN-gamma induced expression of Fc gamma RI and Ia mRNA and cell surface expression ; they enhance IFN-gamma induced Fc gamma RI mRNA and protein expression, yet inhibit IFN-gamma induced Ia mRNA and protein expression ... In this study, we compared the effects of HS and dexamethasone ( DEX ) treatment on the IFN-gamma induction of Fc gamma RI and Ia mRNA in murine primary peritoneal macrophages ... The glucocorticoid antagonist RU 486 blocked both DEX and HS-induced enhancement of IFN-gamma induction of Fc gamma RI , suggesting a common GR-mediated mechanism
Fairchild et al., Clin Diagn Lab Immunol 1996 : Monocytes from healthy, term newborns and adults exhibit comparable baseline and IFN-gamma induced levels of expression of Fc gamma RI and higher baseline and IFN-gamma induced levels of expression of Fc gamma RII
Visnjić et al., Blood 1997 : Treatment of HL-60 cells with indomethacin, an inhibitor of cyclo-oxygenase, and nordihydroguaiaretic acid ( NDGA ), an inhibitor of lipoxygenase, had no effects on IFN-gamma mediated induction of CD64 expression
Fanger et al., J Immunol 1997 : Both DC and monocyte CD64 expression was increased by IFN-gamma and IL-10, but while monocyte CD64 was decreased by IL-4, DC CD64 remained unchanged
Van Weyenbergh et al., J Immunol 1998 (Multiple Sclerosis) : In view of the antagonism of IFN-beta on IFN-gamma action, of interest in the chronic inflammatory disorder multiple sclerosis, we examined the possible effect of IFN-beta on IFN-gamma induction of Fc gamma RI gene expression ... We found that IFN-beta significantly down-regulated IFN-gamma induced Fc gamma RI surface expression in peripheral blood monocytes from healthy donors, in a dose- and time dependent manner