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PTP4A3 — SLC22A3

Text-mined interactions from Literome

Liu et al., Cancer Biol Ther 2009 (Adenocarcinoma...) : But the mechanisms of EMT induced by PRL-3 remain largely unknown ... Here we found that PRL-3 could also promote EMT in a colorectal cancer cell model SW480 with deficient E-cadherin expression in vivo and in vitro ... Glycogen synthase kinase-3beta inactivated by PRL-3 as assessed by phosphospecific antibodies was a key event in EMT induced by PRL-3 ... It provided new insights into the regulatory mechanisms of EMT induced by PRL-3
Lai et al., Med Oncol 2013 (Colorectal Neoplasms) : KCNN4 Channels participate in the EMT induced by PRL-3 in colorectal cancer ... However, the mechanism by which PRL-3 induces tumor cell EMT is unknown ... In the current study, we explored the mechanism by which PRL-3 mediates EMT ... These results implicated the up-regulation of KCNN4 channels in the PRL-3 mediated induction of EMT and promotion of cancer metastasis