Wurz et al., Genes Chromosomes Cancer 2010
(Disease Progression...) :
miR-221 and miR-222 negatively regulate expression of CDKN1B ( p27 ) and CDKN1C ( p57 ), two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas
Sun et al., Zhonghua Wei Chang Wai Ke Za Zhi 2011
(Colorectal Neoplasms) :
miR-221-specific inhibitor significantly enhanced CDKN1C/P57 protein expression, inhibited proliferation of CRC cells and induced apoptosis of CRC cells ( P < 0.01 ) ... miR-221 inhibits CDKN1C/P57 expression by post-transcriptional gene silencing to promote CRC development and progression