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EIF2AK2 — STAT1

Pathways - manually collected, often from reviews:

• WikiPathways Type II interferon signaling (IFNG): Complex of STAT2-STAT1-IRF9-IRF9 → EIF2AK2 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: STAT1 — EIF2AK2 (physical association, affinity chromatography technology) Wong et al., EMBO J 1997*
• IRef Biogrid Interaction: STAT1 — EIF2AK2 (direct interaction, pull down) Wong et al., J Biol Chem 2001*
• IRef Hprd Interaction: EIF2AK2 — STAT1 (in vivo) Wong et al., J Biol Chem 2001*, Wong et al., EMBO J 1997*
• IRef Hprd Interaction: EIF2AK2 — STAT1 (in vitro) Wong et al., J Biol Chem 2001*, Wong et al., EMBO J 1997*
• IRef Ophid Interaction: EIF2AK2 — STAT1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Wong et al., J Biol Chem 2001 : These data substantiate our previous findings on the inhibitory effects of PKR on STAT1 and implicate STAT1 in translational control through the modulation of PKR activation and eIF-2alpha phosphorylation
Härle et al., Virology 2001 : Viral lytic gene transcript and viral protein levels were lower in IFN-beta- versus IFN-alpha 2-transfected cells, which coincided with elevated PKR and OAS transcript levels and increased total STAT1 and phosphorylated STAT1 ( Y701 ) protein levels in the IFN-beta transfected cells
Baran-Marszak et al., Blood 2004 : Expression of STAT1beta inhibited the phosphorylation, the DNA binding activity, and the transcriptional activity of STAT1alpha, as well as the expression of STAT1alpha target genes such as p21WAF1/CIP1, TAP1, IRF1, and PKR
Wang et al., J Biol Chem 2006 : The catalytic activity of the eukaryotic initiation factor-2alpha kinase PKR is required to negatively regulate Stat1 and Stat3 via activation of the T-cell protein-tyrosine phosphatase
Kårehed et al., Mol Immunol 2007 : We find that the serine 727 phosphorylation of Stat1 , required for full IFN-gamma induced FcgammaRI promoter activity, is dependent on PKR ... Our results suggest that IFN-gamma induced increase of FcgammaRI expression requires the integration of two signalling events : PKR dependent Stat1 serine 727 phosphorylation, and activation of NFkappaB
Yoshida et al., Exp Cell Res 2009 : PKR mediated degradation of STAT1 regulates osteoblast differentiation ... The expression and degradation of STAT1 protein were regulated by PKR in a SLIM dependent pathway
Ruuska et al., Arthritis Rheum 2012 : Specific inhibitors were added in cell culture to study the role of PKR and p38 in STAT-1 phosphorylation ... In addition, phosphorylation of STAT-1 was dependent on PKR
Ruuska et al., PloS one 2013 : Specific inhibitors were employed to study the role of PKR in STAT-1 phosphorylation ... Interestingly, STAT-1 serine 727 phosphorylation is partly dependent on PKR
Handy et al., Gene 2013 : PKR activation induced by antiproliferative agent heparin leads to phosphorylation of STAT1 on serine 727, which is essential for the cell cycle block