Shi et al., J Biol Chem 2005
:
Native beta2GPI , but not cleaved beta2GPI, inhibits activation of FXI by thrombin and factor XIIa , attenuating a positive feedback mechanism for additional thrombin generation
McNally et al., Thromb Haemost 1996
(Antiphospholipid Syndrome) :
Factor XIIa generation was dependent on lipoprotein lipase treatment of VLDL and beta 2 GPI inhibited the factor XIIa generation in a concentration dependent manner