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CASP12 — CASP9

Text-mined interactions from Literome

Robertson et al., Crit Rev Toxicol 2000 : Caspase-9 can signal downstream and activate pro-caspase-3 and -7
Viswanath et al., J Neurosci 2001 (Disease Models, Animal...) : Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced Parkinson 's disease ... Caspase-9 inhibition prevented the activation of both caspase-3 and caspase-8 and also inhibited Bid cleavage, but not cytochrome c release
Kilic et al., Cell Death Differ 2002 : Formation of noncanonical high molecular weight caspase-3 and -6 complexes and activation of caspase-12 during serum starvation induced apoptosis in AKR-2B mouse fibroblasts
Feng et al., Am J Physiol Gastrointest Liver Physiol 2002 (Necrosis) : Caspase-3 was activated in primary hepatocytes by STS treatment, but caspase-9 and -12 were not activated , and caspase-3 activation is not dependent on caspase-8
Morishima et al., J Biol Chem 2002 : Cytochrome c-independent activation of caspase-9 by caspase-12 ... These results suggest that caspase-12 can activate caspase-9 without involvement of cytochrome c
Chan et al., Neurobiol Dis 2002 (Alzheimer Disease) : Moreover, activation of caspase-12 , an endoplasmic reticulum ( ER ) -associated caspase , is greatly increased in cells expressing mutant PS1
Robertson et al., Toxicology 2002 (Necrosis) : Caspase-9 can signal downstream and activate pro-caspase-3 and -7
Cuello et al., Cell Death Differ 2004 : Caspase-9 may further activate caspase-8 , generating an amplification loop
Aoyama et al., J Cereb Blood Flow Metab 2005 (Acidosis) : Acidosis also increased caspase-12 mRNA expression, caspase-12 protein expression, cleavage of caspase-12 to its active form, and activation of caspase-3
Martin et al., J Biol Chem 2005 : Caspase-9 cleaves and activates effector caspases, predominantly caspase-3 , resulting in the demise of the cell
Obeng et al., J Biol Chem 2005 : We further demonstrate that ER stress induced apoptosis is a caspase dependent process that does not require the expression of caspase-12 or caspase-4 but can be inhibited by overexpression of Bcl-x ( L ) or a dominant negative caspase-9
Lang-Rollin et al., Apoptosis 2005 : Caspase 9 and 3 are processed, cytochrome c is released from the mitochondria and a dominant negative form of caspase 9 prevents death
Daher et al., Exp Dermatol 2006 : Caspase-9-DN and zLEHD-fmk both suppressed caspase-9 , -3, and -8 activity after UVB exposure, as well as proteolytic processing of procaspase-3 into its active form, DNA fragmentation factor 45 cleavage, and internucleosomal DNA fragmentation
Nakano et al., Cardiovasc Res 2006 : A non-selective caspase inhibitor, z-VAD.fmk ( 100 microM ), inhibited apoptosis and cleavage of caspase-12 stimulated by thapsigargin, while a calpain inhibitor, MDL 28170 ( 120 microM ), inhibited caspase-12 cleavage but not apoptosis
Cervia et al., Apoptosis 2006 (Pituitary Neoplasms) : In addition, we provide evidence that euplotin C treatment results in rapid activation of ryanodine receptors, depletion of Ca2+ stores in the endoplasmic reticulum ( ER ), the release of cytochrome c from the mitochondria, activation of caspase-12 , and activation of caspase-3 , leading to apoptosis
Kumar et al., Cardiovasc Res 2007 (Acidosis...) : Simulated ischemia had no significant effect on caspase-8 cleavage, but induced cleavage of caspase-3 and caspase-12 and led to a slight release of cytochrome C. Prevention of cytosolic acidosis ( anoxia at pH ( o ) 7.4 ) had no effect on cytochrome C release, but significantly reduced apoptosis, attenuated cytosolic Ca2+ overload, and prevented cleavage of caspase-12
Fábián et al., J Virol 2007 (Carcinoma...) : While caspase-8 and caspase-9 are not involved in MTH-68/H induced apoptosis, activation of caspase-3 and caspase-12 was detected in virus infected PC12 cells
Uchiyama et al., Infect Immun 2007 (Necrosis) : Caspase-9 activation was also detected in H37Rv infected cells, but H37Ra never induced such caspase-9 activation
Lin et al., Biochem Biophys Res Commun 2007 (Spinocerebellar Ataxias) : PKCgamma SCA14 mutant proteins were shown to cause aggregation which initially resulted in endoplasmic reticulum ( ER ) stress and cell apoptosis as demonstrated by phosphorylation of PERK on Thr981, activation of caspase-12 , increases in BiP/GRP78 protein levels, and consequent activation of caspase-3
Zhao et al., Tohoku J Exp Med 2008 (Myocardial Infarction...) : Caspase-9 cleaves and activates caspase-3
Tang et al., Oncol Rep 2009 (Adenocarcinoma...) : Caspase-9 and -3 inhibitors almost completely suppressed HCT induced caspase-9 and -3 activities
Shi et al., Toxicol Lett 2010 : Caspase 9 inhibition blocked the TNP induced activation of caspase 3 significantly
Ohsawa et al., Proc Natl Acad Sci U S A 2010 : Maturation of the olfactory sensory neurons by Apaf-1/caspase-9 mediated caspase activity ... Here, we provide unique evidence that Apaf-1/caspase-9 mediated caspase signaling regulates the development of olfactory sensory neurons ( OSNs ), which includes axonal projection, synapse formation, and maturation of these neurons
Park et al., Biochem Pharmacol 2011 : Further analysis using selective caspase inhibitors revealed that caspase-12 activation was required for activation of caspase-9 and -3 to the sufficient level for subsequent activation of caspase-7 and -8
Liu et al., PloS one 2012 : Caspase-9 inhibitor could inhibit activation of pro-caspase-3 , and the inhibition of the function of Apaf-1 with FSBA blocked apoptosis, hinting that Apaf-1 could be involved in Sl-1 cell apoptosis induced by AfMNPV