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CARD8 — NFKB1
Text-mined interactions from Literome
Koseki et al., J Biol Chem 1999
:
Point mutations in highly conserved residues in the CARD of CIPER disrupted the ability of CIPER to activate NF-kappaB and to form homodimers, indicating that the
CARD is
essential for
NF-kappaB activation and dimerization
Bertin et al., J Biol Chem 2000
:
When expressed in cells,
CARD9 binds to BCL10 and
activates NF-kappaB
Bertin et al., J Biol Chem 2001
:
When expressed in cells,
CARD11 and CARD14
activate NF-kappaB and induce the phosphorylation of BCL10
Bouchier-Hayes et al., J Biol Chem 2001
:
Rather,
CARDINAL potently
suppressed NF-kappaB activation associated with overexpression of TRAIL-R1, TRAIL-R2, RIP, RICK, Bcl10, and TRADD, or through ligand induced stimulation of the interleukin-1 or tumor necrosis factor receptors
Fontalba et al., J Immunol 2007
(Arthritis, Rheumatoid) :
Thus,
CARD8 may
control NF-kappaB activation through a regulatory loop ... Thus,
CARD8 may
control NF-kappaB activation through a regulatory loop