Oehlmann et al., J Cell Biol 2004
:
We show that the presence of Cdc6 during S phase is essential for the checkpoint kinase Chk1 to become activated in response to replication inhibition
Chung et al., PLoS Genet 2010
:
The DNA replication licensing protein Cdc6 , which is normally stabilized by Cdk2, was physically associated with the checkpoint regulator ATR and was required for efficient ATR-Chk1-Cdc25A signaling