Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
CDKN1A
→
Complex of CUL1-RBX1-SKP1-SKP2
(decreases, CUL1/RBX1/SKP1/SKP2 Activity)
Evidence: expression of Skp2 in the prostate gland induces hyperplasia, dysplasia and low- grade carcinoma accompanied by increased proliferation, downregulation of p27 and high levels of mitotic markers such as Ki67 and Cyclin B1
OpenBEL Selventa BEL large corpus:
CDKN1A
→
Complex of CUL1-RBX1-SKP1-SKP2
(decreases, CUL1/RBX1/SKP1/SKP2 Activity)
Evidence: targeted Skp2 expression to the T-lymphoid lineage markedly cooperates with the activated oncogene N-Ras. Compared to transgenic animals expressing activated N-Ras alone, Skp2 coexpression causes an acceleration in tumor onset, increased penetrance of lymphomagenesis and decreased survival rate. ectopic expression of Skp2 in nonadherent fibroblasts leads to entry into S phase, p27 downregulation and cell division, indicating that anchorage-dependent growth,a characteristic of nontransformed cell...
KEGG Cell cycle:
Complex of CUL1-RBX1-SKP1-SKP2
→
CDKN1A
(protein-protein, inhibition)