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BMP7 — SOST

Text-mined interactions from Literome

Kusu et al., J Biol Chem 2003 : We examined effects of sclerostin on the activity of BMP2, BMP4, BMP6 , and BMP7 for mouse preosteoblastic MC3T3-E1 cells ... We examined effects of sclerostin on the activity of BMP2, BMP4, BMP6, and BMP7 for mouse preosteoblastic MC3T3-E1 cells ... Sclerostin inhibited the BMP6 and BMP7 activity but not the BMP2 and BMP4 activity
Ohyama et al., Endocrinology 2004 : Spaciotemporal association and bone morphogenetic protein regulation of sclerostin and osterix expression during embryonic osteogenesis
van Bezooijen et al., J Bone Miner Res 2007 : Transcriptional profiling analysis of osteoblastic cultures indicated that sclerostin specifically affects BMP and Wnt signaling out of many other growth signaling pathways ... Sclerostin , however, did not inhibit stimulation of direct BMP target genes ... Sclerostin inhibits BMP stimulated bone formation but does not affect BMP signaling
Krause et al., J Biol Chem 2010 : BMP7 signaling was predominantly inhibited by sclerostin in osteocytes of the calcaneus and the cortical bone of the tibia
Delgado-Calle et al., J Bone Miner Res 2012 : In addition, BMP-2 induced expression of SOST was markedly enhanced in cells demethylated by AzadC
Qin et al., Yi Chuan 2013 : SOST can regulate osteoblastic differentiation and bone formation by binding type I/II receptors and co-receptor LRP5/6 to inhibit BMP and Wnt signaling pathways