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IFNG — IL13

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: IL13 → IFNG (decreases) Chabot et al., Neurology 2000*
  Evidence: Pretreatment of activated T-cells with IFNB1 prior to co-culture with U937 cells treated with PMA and IFNG decreased the levels of TNFA, IL4, IL12, and IL13.

Text-mined interactions from Literome

Lalain et al., Diabetologia 1999 (Diabetes Mellitus, Type 1) : During proliferation in response to islet cells, interleukin-10 increased 43-fold ( p < 0.01 ) but interferon-gamma increased only slightly
Filice et al., Infect Immun 1999 (Cytomegalovirus Infections...) : As pulmonary inflammation developed, levels of cytokine mRNAs for gamma interferon ( IFN-gamma ), interleukin-2 (IL-2), IL-4, and IL-10 increased in bronchoalveolar lavage (BAL) cells or lung tissue, and the level of IFN-gamma protein increased in BAL fluid
Hoshino et al., J Immunol 1999 : These results suggest IL-13 expression induced by IL-2 + IL-18 may be regulated by IFN-gamma in vivo, while IL-10 expression may be IFN-gamma independent
Sugaya et al., J Invest Dermatol 1999 : Interleukin-18 or interleukin-12 alone did not induce interferon-gamma production by dendritic epidermal T cells ... Thus, this study suggests that interleukin-18 and interleukin-12 produced by keratinocytes and Langerhans cells regulate interferon-gamma production by dendritic epidermal T cells and thus may play important parts in the regulation of immune responses in skin associated lymphoid tissues
Elhofy et al., Infect Immun 1999 (Salmonella Infections, Animal) : It has recently been suggested that, interleukin-18 (IL-18), in addition to IL-12, contributes to the induction of IFN-gamma following infection
Dybing et al., Infect Immun 1999 (Salmonella Infections, Animal) : As such, several different cytokines including, interleukin-12 (IL-12) and IL-18, can induce IFN-gamma
Francis et al., Immunology 2000 (Arthritis, Experimental...) : Peptide inhalation induces the production of Th1-type cytokines ( interferon-gamma ) whereas intraperitoneal immunization leads to the production of Th2-type cytokines ( interleukin-4, interleukin-5 and interleukin-10 ) by splenic T cells upon stimulation with peptide
Ruth et al., Cytokine 2000 (Granuloma, Respiratory Tract) : In type-1 GR lungs, anti-IL-4 and anti-IL-13 augmented IFNgamma and TNFalpha mRNA
Morita et al., Rheumatol Int 2001 (Arthritis, Rheumatoid) : Spontaneous interferon-gamma secretion was diminished by IL-4 and IL-10 but not by IL-13
Koh et al., J Clin Immunol 2001 (Asthma...) : As a correlate, interleukin-4 (IL-4) production significantly decreased and interferon-gamma (IFN-gamma) slightly increased , resulting in a markedly decreased ratio of IL-4-IFN-gamma in OVA presensitized rats with BCG infection
Kitagawa et al., J Rheumatol 2001 (Arthritis, Rheumatoid) : Interferon-gamma enhances interleukin 12 production in rheumatoid synovial cells via CD40-CD154 dependent and independent pathways
Sutherland et al., Immunol Rev 2001 : Although ULBPs alone activate multiple signaling pathways and induce modest cytokine production, ULBPs synergize strongly with interleukin-12 for production of interferon-gamma by NK cells
Daines et al., J Biol Chem 2002 : A novel mechanism by which interferon-gamma can regulate interleukin (IL)-13 responses ... These results provide the first evidence that the IL-13Ralpha2 is predominantly an intracellular molecule and demonstrate a novel mechanism by which IFN-gamma can regulate IL-13 responses
Durbin et al., J Immunol 2002 (Pulmonary Eosinophilia...) : In cytokine analyses of infected lung tissue, IFN-gamma was induced in both STAT1 ( -/- ) and wild-type mice, with preferential IL-4, IL-5, and IL-13 induction only in the STAT1 ( -/- ) animals
Puliti et al., Arthritis Rheum 2002 (Arthritis, Infectious...) : The beneficial effect of interleukin-12 on arthritis induced by group B streptococci is mediated by interferon-gamma and interleukin-10 production
Tesfaigzi et al., J Immunol 2002 (Eosinophilia...) : Together, these data demonstrate that reduced IL-13 levels were sufficient to elicit maximum MCM, that IFN-gamma induces Bax in metaplastic mucus cells, and that Bax plays a critical role in the resolution of MCM, but not in the resolution of eosinophils
Xiao et al., J Dermatol Sci 2003 : Both IL-4 and IL-13 inhibit the TNF-alpha and IFN-gamma enhanced MDC production in a human keratinocyte cell line, HaCaT cells ... Both interleukin-4 (IL-4) and IL-13 inhibited TNF-alpha and IFN-gamma enhanced MDC production in HaCaT cells in a dose dependent manner
Malmgaard et al., J Gen Virol 2003 (Herpes Simplex) : Interferon (IFN)-alpha/beta, interleukin (IL)-12 and IL-18 coordinately induce production of IFN-gamma during infection with herpes simplex virus type 2
Tomoda et al., Biochim Biophys Acta 1992 (Leukemia, Monocytic, Acute) : Inhibition of interferon-gamma- and phorbol ester induced HLA-DR and interleukin-1 production by the expression of a transfected poly ( ADP-ribose ) synthetase gene in human leukemia THP-1 cells
Pfaff et al., Parasite Immunol 2003 (Entamoebiasis...) : This study disclosed that IL-18 will significantly down-regulate parasite-specific IL-10 production, whereas IL-12 induced IFN-gamma and inhibited IL-13 production by PBMC from humans exposed to O. volvulus and E. histolytica
Wongpiyabovorn et al., J Dermatol Sci 2003 (Dermatitis, Atopic...) : In contrast, IL-13Ralpha2 mRNA expression was up-regulated by IFN-gamma plus IL-4
Imanishi et al., Hepatogastroenterology 2003 (Carcinoma, Hepatocellular...) : We evaluated interleukin-12 induced interferon-gamma production as one of the immunological markers of patients with chronic liver diseases ... The level of interleukin-12 induced interferon-gamma production by peripheral blood mononuclear cells in the patients with hepatocellular carcinoma was significantly lower than that in the patients with liver cirrhosis which is thought to be a premalignant state
Murray et al., Infect Immun 2003 (Leishmaniasis, Visceral) : Optimal killing triggered by both anti-CD40 and anti-CTLA-4 required endogenous IFN-gamma and involved interleukin 12
Loza et al., Int Immunol 2004 : Adding to our previous report that IL-13 inhibits accumulation of mature IFN-gamma ( + ) NK cells, the present data unravel a mechanism by which peripheral immature IL-13 ( + ) and mature IFN-gamma ( + ) NK cells can negatively regulate each other 's accumulation
Kaufman et al., J Immunol 2004 (Pulmonary Fibrosis) : Interestingly, CD40L expression is down-regulated by IFN-gamma , a type 1 cytokine with antiscarring properties, and is up-regulated by the profibrogenic type 2 cytokine IL-13
Prévot et al., Infect Immun 2004 (Mycobacterium Infections, Nontuberculous...) : Our results indicate, although they do not formally prove, that production of IL-10 rather than production of IL-4 or IL-13 by Th2-type T cells may be involved in the low M. ulcerans-specific IFN-gamma response in Buruli disease patients
dos Santos et al., Vet Immunol Immunopathol 2004 (Dog Diseases...) : Recombinant single-chain canine interleukin 12 induces interferon gamma mRNA expression in peripheral blood mononuclear cells of dogs with visceral leishmaniasis
Grzela et al., Int J Mol Med 2004 (Hypersensitivity) : It could be achieved by administration of missing cytokines, e.g., interferon-gamma (IFN-gamma) and/or down regulation of excessive one, e.g., IL-4, IL-13
Ethuin et al., Lab Invest 2004 : Human neutrophils produce interferon gamma upon stimulation by interleukin-12
Eiwegger et al., Pediatr Res 2004 : Low-molecular-weight fucoidan induced IL-4 production in CD3+CD4+ T cells ( p < 0.05 ) and IL-13 production in CD3+CD8+ T cells ( p < 0.05 ), whereas interferon-gamma production remained unaffected in both T-cell populations
Loughlin et al., Immunology 1992 : Regulation of Fc receptor and major histocompatibility complex antigen expression on isolated rat microglia by tumour necrosis factor, interleukin-1 and lipopolysaccharide : effects on interferon-gamma induced activation
Alexis et al., J Allergy Clin Immunol 2004 : However, inhalation of 10,000 EU enhanced phagocytosis ( monocytes and macrophages ), upregulated expression of CD11b and mCD14 ( monocytes and neutrophils ), and increased IL-13 levels, whereas IFN-gamma levels were significantly decreased
Finkelman et al., J Immunol 2005 (Bronchial Hyperreactivity) : Although IL-4, but not IL-13 , induces IL-12 and IFN-gamma , which suppress many effects of IL-4, IL-12 suppresses only the Ca2T6 gene, and IL-4 induced IFN-gamma production does not suppress the Ca2T6 or SPRR genes
Fernández-Lago et al., J Med Microbiol 2005 (Brucellosis) : Following infection, interleukin-18 (IL-18) may contribute , in association with IL-12, to optimal IFN-gamma production
Ellermann-Eriksen et al., Virology journal 2005 (Herpes Simplex) : In the next wave, interleukin (IL)-12 together with the above and other cytokines induce production of IFN-gamma in mainly NK cells
Corn et al., J Immunol 2005 : In sharp contrast, Bcl-3-null T cells displayed no defect in IFN-gamma production, but their Th2 differentiation and IL-4, IL-5, and IL-13 production were significantly impaired
Wood et al., Eur J Pediatr 2005 (Hypersensitivity) : Defects in interferon-gamma receptor/interleukin-12 receptor responses are not sufficient to cause clinical allergic disease
Rezende et al., Int Endod J 2005 : The cellular viability and the production of tumour necrosis factor-alpha, interleukin (IL)-12 and IL-10 in response to stimulation with interferon-gamma and Fusobacterium nucleatum or Peptostreptococcus anaerobius were evaluated
Koch et al., Am J Respir Cell Mol Biol 2006 (Asthma...) : Cytokine quantification in lungs of mice with allergic airway inflammation revealed that pulmonary IFN-gamma expression increased expression of IL-5 and IL-13
Morris et al., J Immunol 2006 : IL-13 , which signals through the type 2 IL-4R and mimics many IL-4 effects, failed to stimulate IFN-gamma production and, in most experiments, suppressed basal IFN-gamma production
Kriegel et al., Immunology 2006 : Interleukin-4 supports interleukin-12 induced proliferation and interferon-gamma secretion in human activated lymphoblasts and T helper type 1 cells
Al-Attiyah et al., Clin Exp Immunol 2006 (Tuberculosis) : Among the cytokines studied, interleukin (IL)-10 and IL-12 were not detected at all, whereas low levels of interferon (IFN)-gamma after 96 h ( 0.4 IU/ml ) and tumour necrosis factor (TNF)-alpha after 48 ( 135 pg/ml ) and 96 h ( 47 pg/ml ) of culture were detected in the supernatants of whole blood infected with M. tuberculosis
Price et al., Immunology 2007 : Workshop cluster 1+ gammadelta T-cell receptor T cells from calves express high levels of interferon-gamma in response to stimulation with interleukin-12 and -18
Ghiringhelli et al., Immunol Rev 2006 (Disease Progression...) : This review summarizes the findings showing that Tregs suppress NK cell effector functions in vitro and in vivo, i.e. homeostatic proliferation, cytotoxicity, and interleukin-12 mediated IFN-gamma production
Ito et al., J Allergy Clin Immunol 2007 (Asthma) : IFN-gamma reduced the mRNA expression dose-dependently and time-dependently, whereas IL-4 and IL-13 or chemokines did not affect the expression
Do et al., Int J Mol Med 2007 (Asthma...) : In addition, Ag-specific ex vivo IL-4, IL-5 and IL-13 production of draining lymph node cells was markedly diminished by EM-X inhalation, but not IFN-gamma
Tsuda et al., Cancer Res 2007 (Ovarian Neoplasms) : RNAs in ISMMC stimulate immature dendritic cells to secrete interleukin 12 and induce IFN-gamma in peripheral blood mononuclear cells
Ebert et al., Immunology 2008 : Massive interleukin-12 induced interferon-gamma production by interleukin-15 stimulated lamina propria lymphocytes followed by down-regulation of the interleukin-12 receptor
Lonial et al., Exp Hematol 2008 : The immunostimulatory effect of DC1 required DC-to-T-cell contact, and induced interleukin-12 secretion, while DC2 cells induced interferon-gamma secretion
Kubera et al., J Pharmacol Sci 2008 (Cocaine-Related Disorders...) : Cocaine self administered for 18 days induced a significant increase in spleen weight, plasma corticosterone levels, interleukin (IL)-10 , and tumor necrosis factor-alpha production, while concanavalin A-stimulated proliferation responses of peripheral blood T-lymphocytes and interferon-gamma production by splenic lymphocytes were not altered
Campos Alberto et al., Immunology 2009 : Differential effects of tumour necrosis factor-alpha and interleukin-12 on isopentenyl pyrophosphate stimulated interferon-gamma production by cord blood Vgamma9 T cells
Vesosky et al., Infect Immun 2009 (Tuberculosis) : In addition, M. tuberculosis induced IFN-gamma production by CD8 T cells isolated from naïve old mice was major histocompatibility complex class I independent but was dependent on interleukin-12p70 , confirming an innate role of CD8 T cells during M. tuberculosis infection
Bill et al., Mol Cancer Ther 2009 (Melanoma) : Finally, stimulation of natural killer ( NK ) cells with curcumin reduced the level of interleukin-12 induced IFN-gamma secretion, and production of granzyme b or IFN-gamma upon coculture with A375 melanoma cells or NK-sensitive K562 cells as targets
Armstrong-James et al., J Infect Dis 2009 (Pulmonary Aspergillosis) : Impaired interferon-gamma responses, increased interleukin-17 expression, and a tumor necrosis factor-alpha transcriptional program in invasive aspergillosis
Tassi et al., PloS one 2009 (Disease Progression...) : We found that only the combination of IL-12 and IL-27 modified the polarization of Th2 effectors by both reduction of IL-5, GM-CSF and IL-13 and induction of IFN-gamma production, which lasted after cytokine removal
Beldi et al., Hepatology 2010 (Reperfusion Injury) : Specifically, ATPgammaS ( a nonhydrolyzable ATP analog ) inhibits secretion of interferon gamma by NK cells in response to interleukin-12 and interleukin-18, providing a mechanistic link between CD39 deletion and altered cytokine secretion
Kavanagh et al., Clin Exp Allergy 2010 (Disease Models, Animal...) : BPZE1 significantly reduced the levels of OVA-driven IL-4, IL-5 and IL-13 but induced a significant increase in IFN-gamma in response to OVA re-stimulation
Kim et al., Exp Mol Med 2010 (Asthma...) : In addition, the production of OVA-specific IgG2a and IFN-gamma-inducible protein ( IP ) -10 was also impaired in the absence of IL-13 , but not of IL-4
Reiner et al., J Clin Invest 1990 (Leishmaniasis, Visceral) : Interferon-gamma prevents parasite induced inhibition of interleukin 1 production and primes monocytes to respond to Leishmania by producing both tumor necrosis factor-alpha and interleukin 1
Hu et al., Zhongguo Zhong Yao Za Zhi 2010 (Asthma) : After eight weeks, IL-4 and IL-13 in treatment group went down, but IFN-gamma increased
Xie et al., Int J Oncol 1993 : L929 parental cells and L929 cells selected for resistance to tumor necrosis factor ( TNF-alpha ) were incubated in vitro with various concentrations of TNF-alpha, interleukin-1 , and lipopolysaccharide (LPS) in the presence or absence of mouse interferon-gamma (IFN-gamma)
Miossec et al., J Immunol 1986 : Immune interferon enhances the production of interleukin 1 by human endothelial cells stimulated with lipopolysaccharide
Gerrard et al., J Immunol 1987 : Differential effects of interferon-alpha and interferon-gamma on interleukin 1 secretion by monocytes
Haq et al., Immunobiology 1988 : Failure of hydrocortisone to suppress the interferon-gamma induced augmentation of interleukin 1 secretion of aged human monocytes
Auböck et al., Arch Dermatol Res 1985 : HLA-DR expression was induced by the supernatants and human recombinant interferon-gamma ( rIFN-gamma ), whereas recombinant interferon-alpha 2, interleukin-2 and non-recombinant human interferon-beta had no such effect
Hunter et al., Eur J Immunol 1995 (Toxoplasmosis, Animal) : Transforming growth factor-beta inhibits interleukin-12 induced production of interferon-gamma by natural killer cells : a role for transforming growth factor-beta in the regulation of T cell independent resistance to Toxoplasma gondii
Ogata et al., Br J Haematol 1995 (Myelodysplastic Syndromes) : Effects of interleukin-12 on natural killer cell cytotoxicity and the production of interferon-gamma and tumour necrosis factor-alpha in patients with myelodysplastic syndromes
Reiner et al., J Exp Med 1994 (Leishmaniasis, Cutaneous) : Reexamination of the cytokine mRNA at 4 d revealed expression of IL-13 in all strains analyzed, suggesting that IL-2 and IL-13 may mediate the IL-12 independent production of IFN-gamma during the first days after infection
Musso et al., J Exp Med 1994 : We have found that Lsk mRNA and protein were not expressed in resting monocytes but were induced by treatment with interleukin 4 (IL-4) or IL-13 but not by interferon gamma (IFN-gamma) or IL-2
Nakamura et al., Infect Immun 1993 : The factor, interleukin-2 , anti-CD3 MAb, or ConA alone induced a trace of or no detectable IFN-gamma in these cells
Jung et al., Eur J Immunol 1996 : These inhibiting effects were not related to enhanced IFN-gamma production induced by IL-12, since IFN-gamma by itself did not affect IL-13 production
Sanchez-Bueno et al., Biochem Biophys Res Commun 1996 (Fibrosarcoma) : Interferon-gamma dependent expression of inducible nitric oxide synthase, interleukin-12 , and interferon-gamma inducing factor in macrophages elicited by allografted tumor cells
Libraty et al., J Clin Invest 1997 (Leprosy) : Interferon-gamma differentially regulates interleukin-12 and interleukin-10 production in leprosy
Trinchieri et al., Curr Opin Hematol 1997 : If interleukin-12 and interleukin-12 induced interferon gamma are present during early T-cell expansion in response to antigen, T-helper type-1 cell generation is favored and generation of T-helper type-2 cells is inhibited
Gollob et al., Eur J Immunol 1997 : Interferon-gamma and interleukin-4 regulate T cell interleukin-12 responsiveness through the differential modulation of high-affinity interleukin-12 receptor expression
Minty et al., Eur Cytokine Netw 1997 : IL-13 does not significantly inhibit the IL-2 induced T lymphocyte production of IFN-gamma , RANTES, MIP-1 alpha or MIP-1 beta, nor that of perforin mRNA, as does IL-4
Chensue et al., J Immunol 1997 (Granuloma) : IFN-gamma knockout converted the PPD response to a type 2-like pattern with eosinophil infiltration and decreased TNF and RANTES, but increased IL-4, IL-5, IL-10, IL-13 , monocyte chemoattractant protein-3 ( MCP-3 ), and eotaxin expression
Hunter et al., Eur J Immunol 1997 : Comparison of the effects of interleukin-1 alpha, interleukin-1 beta and interferon-gamma inducing factor on the production of interferon-gamma by natural killer
Gross et al., Infect Immun 1998 : Expression of iNOS, interleukin-6 , and tumor necrosis factor alpha (TNF-alpha) mRNAs was induced in both c-Brucella- and ops-Brucella infected cells and was strongly potentiated by IFN-gamma
Hayes et al., Blood 1998 (Cell Transformation, Viral) : Interferon-gamma dependent inducible expression of the human interleukin-12 p35 gene in monocytes initiates from a TATA containing promoter distinct from the CpG-rich promoter active in Epstein-Barr virus transformed lymphoblastoid cells
Baden et al., J Biol Chem 1998 : The amino-terminal domain of STAT4 ( STAT4 ( 1-124 ) ) is required for cooperative binding interactions between STAT4 dimers and activation of interferon-gamma transcription in response to interleukin-12
Yu et al., J Immunol 1998 : We demonstrate that, in primary NK cells, IL-13 , but not IL-4, may induce low levels of IFN-gamma secretion ... When NK cells were costimulated with IL-13 and IL-2, IL-13 generally resulted in two types of reactivity : IL-13 synergized with IL-2 to stimulate IFN-gamma production or it modestly inhibited IL-2 mediated IFN-gamma production ... In both types of donors, the effect of IL-13 on IL-2 induced IFN-gamma production was in marked contrast to the strong inhibition seen with IL-4 in NK cells
Fulton et al., J Infect Dis 1998 : Regulation of interleukin-12 by interleukin-10, transforming growth factor-beta, tumor necrosis factor-alpha, and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra
Byl et al., J Interferon Cytokine Res 1998 (Acquired Immunodeficiency Syndrome) : Bacterial extract OM85-BV induces interleukin-12 dependent IFN-gamma production by human CD4+ T cells
Hodge-Dufour et al., Proc Natl Acad Sci U S A 1998 (Inflammation) : Inhibition of interferon gamma induced interleukin 12 production : a potential mechanism for the anti-inflammatory activities of tumor necrosis factor
Yssel et al., Clin Exp Allergy 1998 (Asthma...) : Both IL-4 and IL-13 are inducing IgE synthesis whereas IFN-gamma and IL-12 are blocking IgE synthesis