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FGB — IL6

Text-mined interactions from Literome

Zupke et al., Biotechnol Bioeng 1998 : Interleukin-6 increased fibrinogen and decreased albumin production
Zhou et al., Zhongguo Yao Li Xue Bao 1999 : To study the effect of fibrin fibrinogen degradation products ( FFDP ) on release of interleukin-1 (IL-1) and interleukin-6 (IL-6) from mouse peritoneal macrophages, and the effect of a new selectively potent protein kinase C inhibitor Ro 31-8220 ( Ro )
Yamaguchi et al., Jpn J Clin Oncol 2000 (Carcinoma, Non-Small-Cell Lung...) : These were basically attributed to systemic leakage of IL-6 from the affected pleural cavity, in which plasma fibrinogen induced in response to serum IL-6 was exudated and degraded predominantly to FDP
Xia et al., Biochem Biophys Res Commun 2000 (Acute-Phase Reaction) : The increased secretion of apolipoprotein B is independent of the acute-phase response, since stimulation of fibrinogen gene expression by interleukin 6 did not affect secretion
Wedzicha et al., Thromb Haemost 2000 (Lung Diseases, Obstructive...) : At baseline, the mean ( SD ) plasma fibrinogen was elevated at 3.9 ( 0.67 ) g/l in the 67 patients with exacerbations during the study and the median ( IQR ) IL-6 at 4.3 ( 2.4 to 6.8 ) pg/ml. Plasma fibrinogen increased by 0.36 ( 0.74 ) g/l at exacerbation ( p < 0.001 )
Ray et al., J Immunol 2000 : Transient transfection and EMSA were performed to investigate the molecular mechanism of IL-6 induced gamma-fibrinogen gene expression in hepatic cells ... These data show that transcription factor SAF-1 is involved in the regulation of IL-6 mediated induction of the human gamma-fibrinogen gene in liver cells
Gervois et al., J Biol Chem 2001 (Inflammation) : In this study, we demonstrate that fibrates decrease basal and IL-6 stimulated expression of the human fibrinogen-beta gene in human primary hepatocytes and hepatoma HepG2 cells ... Fibrates diminish basal and IL-6 induced fibrinogen-beta promoter activity, and this effect is enhanced in the presence of co-transfected PPAR alpha
Fuller et al., Ann N Y Acad Sci 2001 : It is clear that interleukin-6 (IL-6) and its family of cytokines are the major inducers of fibrinogen gene expression ... For example, the proinflammatory cytokine IL-1 beta exerts inhibitory function on IL-6 mediated fibrinogen gene expression
Redman et al., Ann N Y Acad Sci 2001 : Increased secretion of apoB is associated with increased basal expression of fibrinogen and is not affected when fibrinogen expression is stimulated by interleukin-6
Lindmark et al., JAMA 2001 (Angina, Unstable...) : Interleukin 6 (IL-6) induces C-reactive protein and fibrinogen , systemic markers of inflammation
Szaba et al., Blood 2002 (Disease Models, Animal...) : This study also suggests that fibrin regulates chemokine/cytokine production in vivo, as direct injection of thrombin stimulated peritoneal accumulation of IL-6 and MCP-1 in a fibrin(ogen) dependent manner
Müller et al., Diabetologia 2002 (Diabetes Mellitus, Type 2...) : These immune changes seem relevant because IL-6 dependent acute-phase proteins C-reactive protein, serum amyloid A protein and fibrinogen were also increased in IGT and Type II diabetes
Baykal et al., Clin Rheumatol 2003 (Familial Mediterranean Fever) : In FMF patients IL-6 , TNF-alpha, sIL-2r, ESR, CRP and fibrinogen levels increased with the acute-phase reaction, especially in the attack period
Hassan et al., Thromb Haemost 1992 (Carcinoma, Hepatocellular) : We have investigated the effect ( s ) of transforming growth factor (TGF)-beta 1 and interleukin (IL)-6 on the expression of fibrinogen and blood coagulation factors VII, IX, X mRNAs in a hepatoma cell line ( Hep 3B )
Ganapathi et al., Biochem J 1992 (Carcinoma, Hepatocellular...) : Okadaic acid ( OA ), a specific inhibitor of protein phosphatases 1 and 2A, inhibited in a dose dependent manner ( 5-20 nM ) the induction of C-reactive protein (CRP), serum amyloid A (SAA) and fibrinogen by interleukin-6 (IL-6) plus interleukin-1 (IL-1), and of fibrinogen by IL-6 alone, in Hep 3B cells ... OA also inhibited the induction of CRP, fibrinogen and alpha 1-PI by IL-6 in the NPLC/PRF/5 cell line, albeit at a higher concentration ( 80 nM )
Gervois et al., J Biol Chem 2004 (Acute-Phase Reaction) : PPARalpha prevents the IL-6 induced expression of the positive APR genes fibrinogen-alpha , -beta, -gamma, haptoglobulin, and serum amyloid A and the IL-6 induced suppression of the negative APR gene, major urinary protein
Ohta et al., In Vivo 2004 (Disease Models, Animal...) : Involvement of IL-6 and IL-6 receptor in fibrinogen synthesis in the liver of Triton WR-1339 induced hyperlipidemic rats ... These results suggest that the increase in the plasma fibrinogen level is followed by the enhancement of hepatic mRNA expression of beta-chain fibrinogen, IL-6 and IL-6R, that is, IL-6 and IL-6R may partly regulate the plasma fibrinogen level in Triton WR-1339 induced hyperlipidemic rats
Verschuur et al., J Biol Chem 2005 (Inflammation) : The activity of the CCAAT box/enhancer binding protein site ( located 18 nucleotides downstream of the HNF-3 site and important to the IL6 response ) depends on the integrity of the HNF-3 site and vice versa, explaining the necessity of HNF-3 in the IL6 response of the fibrinogen beta promoter
di Minno et al., Cardiovasc Drugs Ther 1992 : However, in view of the role of IL-6 and monocytes in the regulation of plasma fibrinogen levels, it is conceivable that the lowering effect of these drugs involves effects on some steps of the regulatory machinery ... In addition to fibrinogen , IL-6 regulates the synthesis of other acute-phase proteins
Duan et al., J Biol Chem 2006 : Cell type-specific differential induction of the human gamma-fibrinogen promoter by interleukin-6
Natsuka et al., FEBS Lett 1991 : Then, we examined the effect of the overproduced NF-IL6 and delNFIL6 on the expression of haptoglobin, fibrinogen and albumin
Kino et al., J Allergy Clin Immunol 2007 : TB-2-081 suppressed IL-6 induced mRNA expression of alpha1-acid glycoprotein, alpha2-macroglobulin, and beta-fibrinogen in and secretion of the C-reactive protein by rat primary hepatocytes
Kino et al., Eur J Clin Invest 2007 (Acute-Phase Reaction...) : The compound also suppressed interleukin-6 induced mRNA expression of alpha2-acid glycoprotein, beta-fibrinogen and alpha2-macroglobulin in and the secretion of C-reactive protein by rat primary hepatocytes
Albrecht et al., Cell Signal 2007 : In contrast to the mechanism described for the rat gene our results indicate that IL-1beta suppresses the IL-6 induced activation of the human gamma-fibrinogen gene particularly by blocking the late phase STAT3-tyrosine phosphorylation NF-kappaB-dependently but independent from de novo protein synthesis
Broughan et al., J Surg Res 2008 (Reperfusion Injury) : Hepatocytes cultured in Matrigel with HepatoZyme medium at zone 1 and zone 3 oxygen conditions were viable for 1 wk and showed acute phase responses as measured by interleukin-6 induced fibrinogen production
Thacker et al., Exp Mol Pathol 2008 : Adsorbed fibrinogen increased dendritic cell expression of IL-6 , IL-8, MIP-1beta and MCP-1
Guzdek et al., Mediators Inflamm 1997 : In human hepatoma HepG2 cell line curdlan sulphate enhances basal and interleukin-6 stimulated fibrinogen and antichymotrypsin ( ACT ) synthesis, slightly increases basal ceruloplasmin production and exerts only minor effects on alpha-1-proteinase inhibitor and transferrin
Hodgkinson et al., Thromb Haemost 2008 (Inflammation) : In human macrophages fibrinogen stimulated interleukin (IL)6 expression and ERK ( extracellular signal related kinase ) phosphorylation
Lane et al., Biochim Biophys Acta 1991 : Recombinant human interleukin-6 (IL-6) stimulated fibrinogen mRNA levels 4.4-fold over control levels ; this response was blocked by an anti-IL-6 antibody
Lemmers et al., Clin Exp Immunol 2009 (Acute-Phase Reaction...) : The effect of gp130-Fc on fibrinogen secretion induced by IL-6 trans signalling was evaluated on hepatocyte cultures
Morozumi et al., Immunol Invest 2009 : The functional effects of the -455G/A polymorphism on the IL-6 induced expression of the beta-fibrinogen gene may be due to linkage disequilibrium with other functional polymorphisms
Nesbitt et al., Biochim Biophys Acta 1991 : When inhibitors of transcription ( actinomycin-D ) or translation ( cycloheximide ) were added following a maximal induction of fibrinogen mRNA expression by IL-6 , the decay of mRNA was significantly diminished
Amrani et al., Blood Coagul Fibrinolysis 1990 : Our results demonstrated the ability of purified human recombinant interleukin-6 ( originally BSF-2 ) to stimulate fibrinogen production in primary chicken hepatocytes in a dose dependent manner
Rose-John et al., Eur J Biochem 1990 (Carcinoma, Hepatocellular...) : Under conditions of IL-6-receptor up-regulation by dexamethasone, gamma-fibrinogen mRNA induction by IL-6 is stronger and occurs earlier than without dexamethasone
Bauzá et al., J Surg Res 2012 (Acute-Phase Reaction...) : Serum IL-6 levels peaked at 3 h and fibrinogen-? and SAA mRNA levels increased more than 6-fold at 12 h before returning to control levels at 48 h
Bonetto et al., PloS one 2011 (Acute-Phase Reaction...) : IL-6 treatment and STAT3 activation both also induced fibrinogen in cultured C2C12 myotubes
Faber et al., Nutrition & diabetes 2012 : IL-6 and IL-1ß produced by ( pre ) adipocytes were the strongest inducers of fibrinogen and PAI-1 secretion, respectively
Bereta et al., Int J Biochem 1989 : 3. Supernatants from rat peritoneal macrophages and IL-6/IFN-beta 2/BSF-2 obtained from four different laboratories similarly stimulated synthesis of fibrinogen , alpha 1-cysteine proteinase inhibitor and alpha 2-macroglobulin, as well as [ 14C ] -accumulation in cultured hepatocytes
Andus et al., FEBS Lett 1987 (Liver Neoplasms, Experimental) : Recombinant human B cell stimulatory factor 2 ( BSF-2/IFN-beta 2 ) regulates beta-fibrinogen and albumin mRNA levels in Fao-9 cells
Fehér et al., Acta Microbiol Immunol Hung 1995 (Carcinoma, Hepatocellular...) : Dehydroepiandrosterone modulates the spontaneous and IL-6 stimulated fibrinogen production of human hepatoma cells ... The role of an androgen, dehydroepiandrosterone ( DHEA ) has been studied on the constitutive and IL-6 induced fibrinogen production of HepG-2 cells ... Oppositely, for IL-6 induced fibrinogen production, DHEA is strongly inhibitory
Wang et al., J Biol Chem 1995 (Carcinoma, Hepatocellular...) : Hepatoma cell lines stably expressing the Val-135 temperature-sensitive mutant of murine p53 ( wt-like at 32.5 degrees C and mutant-like at 37 degrees C ) were derived from Hep3B cells and tested for the temperature-sensitive phenotype of their ability to synthesize and secrete fibrinogen and alpha 1-antichymotrypsin in response to IL-6
Chen et al., J Biol Chem 1995 : In contrast, the acute-phase gene beta-fibrinogen , which is induced by interleukin-6 but not by interleukin-1 , did not respond to C2-ceramide
Mandl et al., Scand J Immunol 1995 : The effect of fibrinogen degradation products D and E ( FDP-D, FDP-E ) on IL-6 production in perfused mouse livers and peripheral monocytes is studied
Zhou et al., Blood 1993 : The mitogenic effect of fibrinogen and its D fragment was not mediated by induction of IL-6 or granulocyte -- colony stimulating factor secretion, because it was not inhibited by blocking antisera against these two growth factors
Kasza et al., Biol Chem Hoppe Seyler 1994 (Acute-Phase Reaction) : Retinoic acid increased the effect of IL-6 on alpha-1-antichymotrypsin (ACT) and fibrinogen (FBG) on the level of both proteins and mRNAs
Gabay et al., Clin Exp Immunol 1995 (Carcinoma, Hepatocellular) : The production of fibrinogen was increased by IL-6 and decreased by IL-1 ( and TNF-alpha ) in both cell types
Piquet-Pellorce et al., Exp Cell Res 1994 (Carcinoma, Hepatocellular...) : Though IL-6 , LIF, and OSM all stimulate haptoglobin and fibrinogen production by human HepG2 hepatoma cells, the dose-response curves of these three factors exhibit very different characteristics
May et al., J Immunol 1993 : Nevertheless, in mice, if the anti-IL-6 mAb had been administered before the IL-6 inducer, there was a reduction in the in vivo IL-6 induced stimulation of fibrinogen levels, indicating that most of the intravascular IL-6 was not readily available for eliciting hepatocyte effects under these experimental conditions ... Human rIL-6 mixed with `` neutralizing '' mAb in the approximate ratio 1 : 1 elicited an enhanced fibrinogen response in vivo in the mouse ; an IL-6 : mAb ratio of 1 : 125 led to a reduction in the fibrinogen response even though the levels of circulating B9 bioactivity and of human rIL-6-Ag were maximal under these conditions
Vasse et al., Br J Haematol 1996 (Arteriosclerosis...) : IL-4 and IL-13 added to Hep G2 cells down-regulated both the increase of fibrinogen secretion induced by IL-6 and fibrinogen mRNA levels, this effect being more pronounced when Hep G2 were preincubated with the two cytokines before IL-6 addition
Margaglione et al., Fortschr Arzneimittelforsch 1996 : Current evidence indicates that plasma fibrinogen is synthesized by the liver ; that genetic and environmental factors regulate plasma fibrinogen levels ; that interleukin-6 (IL-6) affects the synthesis of plasma fibrinogen by mechanisms involving protein kinase C, and that during the acute-phase response, monocytes generate a variety of monokines including IL-6 ... In addition to fibrinogen , IL-6 also regulates the synthesis of other acute-phase proteins
Vasse et al., Haemostasis 1996 (Arteriosclerosis...) : This was due to both a decrease of IL-6 induced fibrinogen synthesis by hepatocytes, evidenced by a decrease in fibrinogen secretion in the medium and beta chain mRNA expression and to an inhibition of production of the hepatocyte stimulating activity for fibrinogen biosynthesis ( HSF ) by LPS activated monocytes
Lozanski et al., Biochem J 1997 (Carcinoma, Hepatocellular) : In contrast, this pathway does not appear to participate in mediating the inhibitory effects of IL-1beta on fibrinogen induction by IL-6
Liu et al., Biochemistry 1997 : Although stimulation of hepatic cells with interleukin-6 induces the expression of fibrinogen , the molecular basis for this regulation remains largely uncharacterized ... ( iii ) Overexpression of P16 gene in the hepatoma cell lines Hep G2 and Hep 3B enhances the IL-6 induced expression of A alpha fibrinogen ... These results demonstrate that the A alpha-core protein is closely related to P16 and involved in the IL-6 regulated transcription of A alpha fibrinogen
Igaz et al., Cytokine 1998 (Carcinoma, Hepatocellular) : The authors studied the gene expression of junB, a member of the Jun family of transcription factors, and the production of fibrinogen in response to IL-6 and sIL-6R ... The data show that in hepatic cells, endogeneously expressing IL-6R, the IL-6 induced junB and fibrinogen expression is inhibited by the presence of sIL-6R
Karlsson et al., Hepatology 1998 (Carcinoma, Hepatocellular...) : IL-6 induced fibrinogen up-regulation was significantly reduced by heat treatment ( P < .01 ), and secretion rates were indistinguishable from control levels after 2 days ( P > .10 )
Bosze et al., J Pept Res 1998 (Acute-Phase Reaction...) : These results showed that residues 21-34 are critical for eliciting fibrinogen synthesis in the presence or absence of IL-6
Yamaguchi et al., Jpn J Clin Oncol 1998 (Adenocarcinoma...) : Involvement of interleukin-6 in the elevation of plasma fibrinogen levels in lung cancer patients