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CSE — EPHB2
Text-mined interactions from Literome
Kim et al., Exp Mol Med 2009
:
In isolated rat AMs,
CSE induced MMP-9 expression and phosphorylation of
ERK and Akt ... A chemical inhibitor of MEK1/2 or PI3K reduced phosphorylation of
ERK or Akt, respectively, and also
inhibited CSE mediated MMP-9 induction ... Simvastatin attenuated
CSE mediated activation of RAS and phosphorylation of
ERK , Akt, p65, IkappaB, and nuclear AP-1 or NF-kappaB activity
Shen et al., Am J Pathol 2011
(Pulmonary Disease, Chronic Obstructive) :
Further examination showed that EGR-1 in turn regulated Erk1/2 activity because inhibition of EGR-1 transcription activity decreased
CSE induced
Erk1/2 phosphorylation
Simone et al., PloS one 2011
:
Lycopene further inhibited
CSE induced phosphorylation of the redox-sensitive
ERK1/2 , JNK and p38 MAPKs
Palozza et al., Inflamm Allergy Drug Targets 2012
:
Moreover, lycopene inhibited
CSE induced
ERK1/2 and NF-?B activation in a dose dependent manner