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BDNF — BMP2
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Mizuno et al., Cell Biol Int 2007
:
Nerve growth factor (NGF),
brain derived neurotrophic factor (BDNF) , neurotrophin (NT)-3 and NT-4/5
increased the mRNA levels of dentin sialophsphoprotein, alkaline phosphatase, osteopontin, type I collagen and
bone morphogenetic protein-2 and mineral deposition in cultures of HP cells
Kajiya et al., J Biol Chem 2008
:
In this study, we examined how
BDNF regulates the mRNA expression of bone/cementum related proteins ( alkaline phosphatase (ALP), osteopontin (OPN), and
bone morphogenetic protein-2 (BMP-2) ) in cultures of immortalized human cementoblast-like ( HCEM ) cells ... These findings provide the first evidence that the TrkB-c-Raf-ERK1/2-Elk-1 signaling pathway is required for the
BDNF induced mRNA expression of ALP, OPN, and
BMP-2 in HCEM cells