Goodwin et al., J Biol Chem 2003
:
In particular, homophilic cadherin ligation can directly activate Rho family GTPases and phosphatidylinositol 3-kinase ( PI3-kinase ), signaling molecules with the capacity to support the morphogenetic effects of these adhesion molecules during development and disease ... In contrast, cadherin activated PI3-kinase signaling was not affected by loss of p120-ctn binding
Owens et al., J Cell Sci 2003
(Cell Transformation, Neoplastic...) :
Responsiveness to TGFbeta could be restored by inhibiting cadherin mediated cell-cell adhesion or phosphoinositide 3-kinase (PI3-K) activity, but not by inhibiting mitogen activated protein kinase ( MAPK ) activity
Lau et al., Oncogene 2011
(Ovarian Neoplasms) :
In this study, we showed that loss of E-cadherin induced ovarian cancer cell growth and constitutive activation of phosphoinositide 3-kinase (PI3K)/Akt signaling by the inhibition of phosphatase and tensin homolog (PTEN) transcription through the downregulation of early growth response gene 1 (Egr1)