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JAK2 — TPO
Text-mined interactions from Literome
Yang et al., Blood 1999
:
In addition, hG-CSF
induced phosphorylation of STAT3 but not
Jak2 or STAT5, while
TPO induced phosphorylation of both
Wang et al., Blood 2000
:
Previous studies indicated that
Janus kinase ( JAK ) and its substrates
mediate the effects of
TPO on cellular proliferation and survival
Iijima et al., Leukemia 2000
(Leukemia, Lymphoid...) :
Triggering of these cell lines by
TPO transiently
up-regulated tyrosine phosphorylation of
JAK-2 and Shc, indicating that their receptor is functional
Lannutti et al., Oncogene 2006
(Thrombocytosis) :
Mechanistic studies revealed that
TPO stimulation of MKs from lyn ( -/- ) mice did not
affect phosphorylation of
Janus kinase 2 (JAK2) , signal transducer and activator of transcription ( STAT ) 3, STAT5, or MAP kinase kinase ( MEK )
Baker et al., Cardiovasc Res 2008
(Myocardial Infarction...) :
Tpo activated
JAK-2 ( Janus kinase-2 ) and p44 MAPK ( mitogen activated protein kinase ) during reperfusion but not prior to ischaemia
Kanaji et al., Eur J Haematol 2008
(Thrombocytopenia) :
Although no mutations were identified in MPL, Mpl protein was absent in the platelets and
TPO induced phosphorylation of the
Janus tyrosine kinase 2 (Jak2) was not
detected
Hitchcock et al., Blood 2008
:
After Tpo stimulation, internalization was greatly reduced in c-Mpl Y ( 78 ) F and c-Mpl Y ( 8+78 ) F, and these cell lines also exhibited increased proliferation and increased strength and duration of
Jak2 , STAT5, AKT, and ERK1/2 activation in
response to
Tpo
Kuter et al., Int J Hematol 2013
:
TPO binds the TPO receptor,
activates JAK and STAT pathways, thus stimulating megakaryocyte growth and platelet production
Tortolani et al., Blood 1995
(Leukemia) :
TPO also
induced activation of
JAK2 phosphotransferase activity in vitro
Pallard et al., EMBO J 1995
(Leukemia, Megakaryoblastic, Acute) :
We demonstrated that
TPO activates the kinase
JAK2 and a STAT5-like transcriptional factor but not STAT1, STAT2, STAT3 or STAT4, in a very rapid and transient manner
Nagata et al., Leukemia 1997
:
Study on signal transduction through Mp1 revealed that
Tpo induces activation of
JAK2 and Tyk2, which in turn activate STAT1, STAT3 and STAT5
Leven et al., Blood Cells Mol Dis 1997
:
Studies on protein phosphorylation revealed that IL6, but not
TPO ,
stimulated phosphorylation of JAK1,
JAK2 and MAP kinase