◀ Back to JAK2
EPOR — JAK2
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
EPOR
→
JAK2
(directlyIncreases, EPOR Activity)
Evidence: 10579919;12027890
-
BioCarta erythropoietin mediated neuroprotection through nf-kb:
EPO/EPO R/EPO R/JAK2/JAK2 complex (EPOR-JAK2-EPO)
→
p50/RELA/I-kappa-B-alpha complex (RELA-NFKBIA)
(protein ubiquitination, activates)
-
BioCarta erythropoietin mediated neuroprotection through nf-kb:
EPO/EPO R/EPO R/JAK2/JAK2 complex (EPOR-JAK2-EPO)
→
I-kappa-B-alpha/RELA/p50/ubiquitin complex (NFKBIA-RELA)
(protein ubiquitination, activates)
-
BioCarta epo signaling pathway:
EPO/EPO R/EPO R complex (EPOR-EPO)
→
JAK2
(modification, activates)
-
BioCarta erythropoietin mediated neuroprotection through nf-kb:
EPO
→
EPO/EPO R/EPO R/JAK2/JAK2 complex (EPOR-JAK2-EPO)
(modification, collaborate)
-
BioCarta erythropoietin mediated neuroprotection through nf-kb:
EPO
→
EPO R/EPO R/JAK2/JAK2 complex (EPOR-JAK2)
(modification, collaborate)
-
BioCarta erythropoietin mediated neuroprotection through nf-kb:
EPO/EPO R/EPO R/JAK2/JAK2 complex (EPOR-JAK2-EPO)
→
EPO R/EPO R/JAK2/JAK2 complex (EPOR-JAK2)
(modification, collaborate)
-
KEGG Jak-STAT signaling pathway:
CNTFR/CRLF2/CSF2RA/CSF2RB/CSF3R/EPOR/GHR/IFNAR1/IFNAR2/IFNGR1/IFNGR2/IFNLR1/IL10RA/IL10RB/IL11RA/IL12RB1/IL12RB2/IL13RA1/IL13RA2/IL15RA/IL20RA/IL20RB/IL21R/IL22RA1/IL22RA2/IL23R/IL2RA/IL2RB/IL2RG/IL3RA/IL4R/IL5RA/IL6R/IL6ST/IL7R/IL9R/LEPR/LIFR/MPL/OSMR/PRLR
→
JAK1/JAK2/JAK3/TYK2
(protein-protein, phosphorylation)
-
NCI Pathway Database EPO signaling pathway:
EPO/EPOR (dimer)/JAK2 complex (EPO-EPOR-JAK2)
→
TRPC6 (TRPC6)
(elevation of cytosolic calcium ion concentration, collaborate)
Chu et al., J Biol Chem 2004*
-
NCI Pathway Database EPO signaling pathway:
EPO/EPOR (dimer)/JAK2 complex (EPO-EPOR-JAK2)
→
STAT5 (STAT5A/STAT5B)
(modification, activates)
Penta et al., J Biol Chem 1995
Evidence: assay, other species
-
NCI Pathway Database EPO signaling pathway:
EPO/EPOR (dimer)/JAK2 complex (EPO-EPOR-JAK2)
→
EPO/EPOR (dimer)/LYN complex (EPO-EPOR-LYN)
(modification, activates)
Penta et al., J Biol Chem 1995
Evidence: assay, other species
-
NCI Pathway Database EPO signaling pathway:
SHP1 (PTPN6)
→
EPO/EPOR (dimer)/JAK2/SOCS3 complex (EPO-EPOR-JAK2-SOCS3)
(modification, inhibits)
Tong et al., Blood 2005, Klingmüller et al., Cell 1995, Witthuhn et al., Cell 1993
Evidence: assay, other species
-
NCI Pathway Database EPO signaling pathway:
SHP1 (PTPN6)
→
EPO/EPOR (dimer)/JAK2 complex (EPO-EPOR-JAK2)
(modification, inhibits)
Tong et al., Blood 2005, Klingmüller et al., Cell 1995, Witthuhn et al., Cell 1993
Evidence: assay, other species
-
NCI Pathway Database EPO signaling pathway:
EPO/EPOR (dimer) complex (EPO-EPOR)
→
EPO/EPOR (dimer)/JAK2/SOCS3 complex (EPO-EPOR-JAK2-SOCS3)
(modification, collaborate)
Tong et al., Blood 2005, Klingmüller et al., Cell 1995, Witthuhn et al., Cell 1993
Evidence: assay, other species
-
NCI Pathway Database EPO signaling pathway:
EPO/EPOR (dimer) complex (EPO-EPOR)
→
EPO/EPOR (dimer)/JAK2 complex (EPO-EPOR-JAK2)
(modification, collaborate)
Tong et al., Blood 2005, Klingmüller et al., Cell 1995, Witthuhn et al., Cell 1993
Evidence: assay, other species
-
NCI Pathway Database EPO signaling pathway:
EPO/EPOR (dimer) complex (EPO-EPOR)
→
JAK2 (JAK2)
(modification, collaborate)
Tong et al., Blood 2005, Klingmüller et al., Cell 1995, Witthuhn et al., Cell 1993
Evidence: assay, other species
-
NCI Pathway Database EPO signaling pathway:
LNK (SH2B3)
→
EPO/EPOR (dimer)/JAK2/SOCS3 complex (EPO-EPOR-JAK2-SOCS3)
(modification, inhibits)
Tong et al., Blood 2005, Klingmüller et al., Cell 1995, Witthuhn et al., Cell 1993
Evidence: assay, other species
-
NCI Pathway Database EPO signaling pathway:
LNK (SH2B3)
→
EPO/EPOR (dimer)/JAK2 complex (EPO-EPOR-JAK2)
(modification, inhibits)
Tong et al., Blood 2005, Klingmüller et al., Cell 1995, Witthuhn et al., Cell 1993
Evidence: assay, other species
-
NCI Pathway Database EPO signaling pathway:
EPO/EPOR (dimer)/JAK2/SOCS3 complex (EPO-EPOR-JAK2-SOCS3)
→
EPO/EPOR (dimer)/JAK2 complex (EPO-EPOR-JAK2)
(modification, collaborate)
Tong et al., Blood 2005, Klingmüller et al., Cell 1995, Witthuhn et al., Cell 1993
Evidence: assay, other species
-
NCI Pathway Database EPO signaling pathway:
EPO/EPOR (dimer)/JAK2/SOCS3 complex (EPO-EPOR-JAK2-SOCS3)
→
JAK2 (JAK2)
(modification, collaborate)
Tong et al., Blood 2005, Klingmüller et al., Cell 1995, Witthuhn et al., Cell 1993
Evidence: assay, other species
-
NCI Pathway Database EPO signaling pathway:
EPO/EPOR (dimer)/JAK2/SOCS3 complex (EPO-EPOR-JAK2-SOCS3)
→
SOCS3 (SOCS3)
(modification, collaborate)
Tong et al., Blood 2005, Klingmüller et al., Cell 1995, Witthuhn et al., Cell 1993
Evidence: assay, other species
-
NCI Pathway Database EPO signaling pathway:
EPO/EPOR (dimer)/JAK2 complex (EPO-EPOR-JAK2)
→
JAK2 (JAK2)
(modification, collaborate)
Tong et al., Blood 2005, Klingmüller et al., Cell 1995, Witthuhn et al., Cell 1993
Evidence: assay, other species
-
NCI Pathway Database EPO signaling pathway:
EPO/EPOR (dimer)/JAK2 complex (EPO-EPOR-JAK2)
→
SOCS3 (SOCS3)
(modification, collaborate)
Tong et al., Blood 2005, Klingmüller et al., Cell 1995, Witthuhn et al., Cell 1993
Evidence: assay, other species
-
NCI Pathway Database EPO signaling pathway:
EPO/EPOR (dimer)/JAK2 complex (EPO-EPOR-JAK2)
→
EPO/EPOR (dimer)/LYN complex (EPO-EPOR-LYN)
(modification, activates)
Ren et al., J Biol Chem 1994*
Evidence: assay
-
NCI Pathway Database EPO signaling pathway:
EPO/EPOR (dimer)/JAK2 complex (EPO-EPOR-JAK2)
→
EPO/EPOR (dimer)/LYN complex (EPO-EPOR-LYN)
(modification, activates)
Penta et al., J Biol Chem 1995
Evidence: assay, other species
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
JAK2
—
EPOR
(physical association, affinity chromatography technology)
van den Akker et al., Blood 2004*
-
IRef Biogrid Interaction:
JAK2
—
EPOR
(physical association, affinity chromatography technology)
Huang et al., Mol Cell 2001*
-
IRef Biogrid Interaction:
JAK2
—
EPOR
(direct interaction, pull down)
Huang et al., Mol Cell 2001*
-
IRef Biogrid Interaction:
JAK2
—
EPOR
(direct interaction, pull down)
Witthuhn et al., Cell 1993
-
IRef Hprd Interaction:
JAK2
—
EPOR
(in vivo)
Huang et al., Mol Cell 2001*, Ketteler et al., J Biol Chem 2003*, Witthuhn et al., Cell 1993
-
IRef Hprd Interaction:
JAK2
—
EPOR
(in vitro)
Huang et al., Mol Cell 2001*, Ketteler et al., J Biol Chem 2003*, Witthuhn et al., Cell 1993
-
IRef Ophid Interaction:
JAK2
—
EPOR
(aggregation, confirmational text mining)
Witthuhn et al., Cell 1993
-
IRef Ophid Interaction:
JAK2
—
EPOR
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Digicaylioglu et al., Nature 2001
:
We show that
EPOR mediated activation of
Jak2 leads to phosphorylation of the inhibitor of NF-kappaB ( IkappaB ), subsequent nuclear translocation of the transcription factor NF-kappaB, and NF-kappaB dependent transcription of neuroprotective genes
Royer et al., DNA Cell Biol 2004
:
Epo dependent proliferation assays and analysis of
Jak2 dependent
EpoR cell-surface expression showed that these vectors were able to function indistinguishable from the original pMX-EpoR-IRES-GFP
Kakihana et al., Biochem Biophys Res Commun 2005
:
Binding studies using various EpoR mutants in hematopoietic cells showed that CaM binds the membrane-proximal 65-amino-acid cytoplasmic region ( amino acids 258-312 ) of EpoR that is critical for activation of
Jak2 mediated
EpoR signaling ... Together, these results indicate that CaM binds to the membrane-proximal EpoR cytoplasmic region and plays an essential role in activation of
Jak2 mediated
EpoR signaling
Lu et al., J Biol Chem 2008
(Cell Transformation, Neoplastic) :
We further showed that disruption of EpoR dimerization by coexpressing a truncated EpoR disrupted JAK2V617F mediated transformation, indicating that
EpoR dimerization
plays an essential role in the activation of
JAK2V617F
Funakoshi-Tago et al., Mol Cell Biol 2008
:
Jak2 FERM domain interaction with the
erythropoietin receptor regulates
Jak2 kinase activity
Funakoshi-Tago et al., J Biol Chem 2010
(Cell Transformation, Neoplastic...) :
Although it remains unclear why the presence of
EpoR is
required to activate oncogenic signaling via the
JAK2 mutant and STAT5, its interacting ability is a target for the treatment of these hematopoietic diseases
Griner et al., Br J Haematol 2013
(Leukemia, Erythroblastic, Acute...) :
Recent work has suggested a potential role for cellular cholesterol in the
activation of
JAK2 by the
erythropoietin receptor and in the development of an MPN-like disorder in mice
Klingmüller et al., Cell 1995
:
The binding of erythropoietin (EPO) to its receptor (
EPO-R )
activates the protein tyrosine kinase
JAK2
Klingmüller et al., Proc Natl Acad Sci U S A 1997
:
Homodimerization of the
erythropoietin (EPO) receptor ( EPO-R ) in response to EPO binding transiently
activates the receptor associated protein tyrosine kinase
JAK2
Cohen et al., Biochem J 1997
:
Both EPO-R and JAK2 were phosphorylated with similar kinetics by PV treatment, suggesting that
JAK2 , as well as protein Tyr kinases different from JAK2, might
mediate PV-dependent
EPO-R phosphorylation
Chin et al., Blood 1998
:
These results suggest that Lyn may play a role in
activation of the
Jak2/Stat5 and other signaling pathways by the
EpoR