Sabina et al., Haematologica 2006
(Anemia, Hemolytic, Congenital...) :
Exposure to a calmodulin antagonist significantly slows IMP accumulation during experimental energy imbalance in patients ' cells to levels that are similar to those in untreated controls, implying that Ca2+-calmodulin is involved in erythrocyte AMP deaminase activation in familial phosphofructokinase deficiency
Sabina et al., Br J Haematol 2009
(Anemia, Sickle Cell) :
Ca2+-calmodulin (Ca2+-CaM) activates erythrocyte adenosine monophosphate deaminase ( AMPD ) in conditions of disturbed calcium homeostasis, prompting us to investigate adenine nucleotide metabolic dysregulation in sickle cell disease (SCD) ... We conclude that Ca2+-CaM activation of AMPD contributes to increased turnover of the adenine nucleotide pool in sickle erythrocytes and that this metabolic dysregulation promotes PS exposure that may contribute to the pathogenesis of SCD