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GSK3B — INSR

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: INSR → GSK3B (directlyIncreases, INSR Activity)
  Evidence: The insulin receptor and some of its substrates are also subject to serine/threonine phosphorylation. Data from some experimental models suggest that this might represent a mechanism by which signaling is terminated, or perhaps attenuated in states of insulin resistance. Numerous in vitro studies have shown that the tyrosine kinase activity of the receptor decreases as a consequence of serine/threonine phosphorylation. This might occur via feedback "retrophosphorylation" events in which the rec...