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MAPK15 — SYK
Text-mined interactions from Literome
Canobbio et al., Thromb Haemost 2004
:
How-ever, phosphorylation of
p38MAPK was
prevented by the tyro-sine kinase
Syk inhibitor piceatannol
Hayashi et al., J Biol Chem 2004
:
It also elicited tyrosine phosphorylation of DAP12, Syk, and SLP-76, and a
Syk inhibitor
blocked the promotion of phagocytosis and activation of
MAPK by SIRPbeta
Takada et al., J Immunol 2004
:
Overall, our results demonstrate that
Syk activation
plays an essential role in TNF induced activation of JNK, p38 MAPK, p44/p42
MAPK , NF-kappaB, and apoptosis
Ulanova et al., Biochem Biophys Res Commun 2006
:
Inhibition of
Syk down-regulated TNF induced p38 and p44/42
MAPK phosphorylation and nuclear translocation of p65 NF-kappaB
Wang et al., J Immunol 2006
:
Syk is downstream of intercellular adhesion molecule-1 and
mediates human rhinovirus activation of p38
MAPK in airway epithelial cells
Lau et al., J Immunol 2008
:
We recently demonstrated the Syk tyrosine kinase to be an important mediator of HRV-ICAM-1 signaling :
Syk regulates replication independent p38
MAPK activation and IL-8 expression
Honda et al., J Biol Chem 1997
:
The onsets of the series of events including tyrosyl phosphorylation of
Syk ,
mitogen activated protein ( MAP ) kinase activation , elevation of intracellular calcium concentration ( [ Ca2+ ] i ), and histamine release were all stepwisely delayed in Csk expressing cells and in mCsk expressing cells
Jiang et al., J Exp Med 1998
:
However, BCR mediated p38 MAPK activation was abolished in Lyn/Syk double deficient cells, demonstrating that either Lyn or
Syk alone may be
sufficient to activate p38
MAPK