Moustafa et al., J Invest Dermatol 2002
:
We have previously shown that alpha-MSH can inhibit tumor necrosis factor-alpha stimulated intercellular adhesion molecule 1 upregulation and nuclear factor kappaB (NFkappaB) transcription factor activation in melanocyte and melanoma cells
Scholzen et al., Endocrinology 2003
(Vasculitis) :
In addition, alpha-MSH significantly impaired the LPS induced ICAM-1 and VCAM-1 mediated adhesion of lymphocytes to HDMEC monolayer in a functional adhesion assay
Hill et al., Peptides 2006
:
The present study confirms MC1R expression in cultured human dermal fibroblasts and reports that the MSH peptides alpha-MSH and KP ( -D- ) V inhibit TNF-alpha stimulated NF-kappaB activity and ICAM-1 upregulation, consistent with an anti-inflammatory role
Morandini et al., J Cell Physiol 1998
(Melanoma) :
We conducted a study in order to evaluate the possible effect of MSH on ICAM-1 expression in human cultured malignant and normal melanocytes
Hedley et al., Br J Dermatol 1998
(Melanoma) :
The maximum inhibitory response to alpha-MSH was obtained at around 10 ( -10 ) mol/L alpha-MSH when cells were coincubated with alpha-MSH and TNF-alpha for 24 h. alpha-MSH had little or no effect on basal ICAM-1 expression in melanocytes and the effects of alpha-MSH could be mimicked with 3-isobutyl-1-methylxanthine ( IBMX )