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ATR — CDKN1A

Text-mined interactions from Literome

Ding et al., Biochem Biophys Res Commun 2003 (Lung Neoplasms) : Caffeine, an ataxia telangiectasia mutated (ATM), and ATM- and Rad3 related kinase (ATR) inhibitor, abrogated genistein induced p21 ( WAF1/Cip1 ) and largely blocked etoposide induced p21 ( WAF1/Cip1 ) expression
Bendjennat et al., Cell 2003 : ATR activation after UV irradiation is essential for signaling p21 degradation
Pedram et al., Mol Biol Cell 2009 : ATR-phosphorylation of p53 induces p21 transcription, prevented by E ( 2 ) /ER
Lei et al., Photochem Photobiol Sci 2010 : Degradation of p21 following UVB radiation does not require ATR , ATM, or both, because either the ATR/ATM inhibitor caffeine or siRNA knockdown of ATR, ATM, or both failed to reverse p21 degradation
Al-Khalaf et al., Mol Carcinog 2012 : ATR controls the p21 ( WAF1/Cip1 ) protein up-regulation and apoptosis in response to low UV fluences ... Since the protein kinase ATR plays a major role in the cellular response to these carcinogenic lesions, we investigated the possible role of ATR in the modulation of p21 ( WAF1/Cip1 ) expression in response to UVC radiation