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LEP — LIPE

Text-mined interactions from Literome

O'Rourke et al., Diabetes 2001 : We investigated the effects of leptin on hormone-sensitive lipase (HSL) , which acts as a neutral cholesterol esterase in macrophages and is a rate limiting step in cholesterol ester breakdown ... Leptin significantly increased HSL activity in J774.2 macrophages, and these effects were additive with the effects of cAMP and were blocked by PI 3-kinase inhibitors
Li et al., Sheng Wu Gong Cheng Xue Bao 2008 : The results showed that 100 nmol/L leptin up-regulated the mRNA expression of ATGL, TGH-2, HSL , MGL and LPL ( P < 0.01 ), but down-regulated the Perilipin mRNA expression ( P < 0.01 ). At the same time, leptin promoted the glycerol release in a dose dependent manner ( P < 0.01 ), but had no effect on the FFA release ( P > 0.05 )