Rössler et al., Arch Biochem Biophys 2008
(Neuroblastoma) :
Expression experiments revealed that both MKP-1 and a constitutively active mutant of calcineurin A impaired carbachol induced upregulation of AP-1 activity
Lee et al., J Immunol 2008
(Encephalitis) :
Of interest, the negative effects of 15d-PGJ ( 2 ) on AP-1/specificity protein-1 signaling and the resulting inhibition of MCP-1 expression were mediated by MAPK phosphatase (MKP)-1 activity, which was induced by 15d-PGJ ( 2 ) in a peroxisome proliferator activated receptor independent manner
Casals-Casas et al., Eur J Immunol 2009
:
CREB and AP-1 activation regulates MKP-1 induction by LPS or M-CSF and their kinetics correlate with macrophage activation versus proliferation
Murciano et al., Infect Immun 2011
(Inflammation) :
This occurs through phosphorylation of the MAPK phosphatase MKP1 and activation of the c-Fos transcription factor by the hyphal form