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FOSB — JUN

Pathways - manually collected, often from reviews:

• NCI Pathway Database AP-1 transcription factor network: JUN/FOSB complex (FOSB-JUN) → JUN (JUN) (modification, collaborate) Smeal et al., Nature 1991*, Humar et al., Int J Biochem Cell Biol 2007*, Ryseck et al., Oncogene 1991, Ryseck et al., Oncogene 1990*, Zerial et al., EMBO J 1989*, Skinner et al., Mol Cell Biol 1997*
  Evidence: physical interaction
• NCI Pathway Database AP-1 transcription factor network: JUN/FOSB complex (FOSB-JUN) → FOSB (FOSB) (modification, collaborate) Smeal et al., Nature 1991*, Humar et al., Int J Biochem Cell Biol 2007*, Ryseck et al., Oncogene 1991, Ryseck et al., Oncogene 1990*, Zerial et al., EMBO J 1989*, Skinner et al., Mol Cell Biol 1997*
  Evidence: physical interaction
• NCI Pathway Database AP-1 transcription factor network: JUN (JUN) → FOSB (FOSB) (modification, collaborate) Smeal et al., Nature 1991*, Humar et al., Int J Biochem Cell Biol 2007*, Ryseck et al., Oncogene 1991, Ryseck et al., Oncogene 1990*, Zerial et al., EMBO J 1989*, Skinner et al., Mol Cell Biol 1997*
  Evidence: physical interaction
• NCI Pathway Database AP-1 transcription factor network: JUN/FOSB complex (FOSB-JUN) → TH (TH) (transcription, inhibits) Gizang-Ginsberg et al., Mol Endocrinol 1994*
  Evidence: physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: FOSB — JUN Newman et al., Science 2003
• IRef Bind_translation Interaction: FOSB — JUN (array technology) Newman et al., Science 2003
• IRef Dip Interaction: Complex of JUN-FOSB-MECOM-JUNB-YY1-FOS-FOSL2 (anti bait coimmunoprecipitation) Bard-Chapeau et al., Proc Natl Acad Sci U S A 2012
• IRef Ophid Interaction: FOSB — JUN (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Pearse et al., Brain Res 2001 : In contrast, FosB was induced and continued to rise in all areas, whereas the basal expressions of c-Jun and Krox-24 were initially reduced but then returned during the subsequent 36 h
Inoue et al., J Neurosci Res 2003 : Fos-B expression is required for polyamine induced increase in nuclear activator protein-1 DNA binding in discrete structures of murine brain
Yang et al., Pigment Cell Res 2004 (Melanoma) : There are progressive variations in AP-1 composition in different melanoma cell lines compared with normal melanocytes, in which c-Jun, JunD and FosB were involved in AP-1 complexes
Nakabeppu et al., Cell 1991 : Rather, delta FosB inhibits gene activation by Jun or Jun + Fos and inhibits repression of the c-fos promoter by FosB or c-Fos, presumably by competing with full-length Fos proteins at the steps of dimerization with Jun and binding to DNA
Dai et al., Hum Reprod 2011 (Pre-Eclampsia) : Both JunB/FosB and p65 were increased in placenta from women with severe pre-eclampsia versus a normal pregnancy, with elevated expression of miR-155 ( P < 0.05 )
Hong et al., J Leukoc Biol 2011 : AP-1 protein induction during monopoiesis favors C/EBP : AP-1 heterodimers over C/EBP homodimerization and stimulates FosB transcription