◀ Back to KIT

KIT — MITF

Text-mined interactions from Literome

Wen et al., Pigment Cell Melanoma Res 2010 : In vitro, KIT signaling leads to MITF phosphorylation, affecting MITF activity and stability
Lee et al., Blood 2011 (Mastocytosis, Systemic) : KIT signaling regulates MITF expression through miRNAs in normal and malignant mast cell proliferation ... We found that miR-539 and miR-381 are down-regulated by KIT signaling and they repressed MITF expression through conserved miRNA binding sites in the MITF 3'-untranslated region
Phung et al., PloS one 2011 : In this study, we therefore sought to identify the signaling pathways and mechanisms involved in c-KIT mediated regulation of Mitf ... We report that c-KIT stimulation leads to the activation of Mitf specifically through the c-KIT phosphorylation sites Y721 ( PI3 kinase binding site ), Y568 and Y570 ( Src binding site ) ... Using specific inhibitors we observe and verify that c-KIT induced activation of Mitf is dependent on PI3-, Akt-, Src-, p38- or Mek kinases ... Our results reveal novel mechanisms by which c-KIT signaling regulates Mitf , with implications for understanding both melanocyte development and melanoma