◀ Back to NFKB1

MAP3K3 — NFKB1

Text-mined interactions from Literome

Zhao et al., J Biol Chem 1999 : We now show that MEKK2 and MEKK3 can in vivo activate IKK-alpha and IKK-beta, induce site-specific IkappaBalpha phosphorylation, and, relatively modestly, activate an NF-kappaB reporter gene ... In addition, dominant negative versions of either IKK-alpha or IKK-beta abolish NF-kappaB activation induced by MEKK2 or MEKK3 , thereby providing evidence that these IKKs mediate the NF-kappaB inducing activities of these MEKKs
Yang et al., Nat Immunol 2001 : The essential role of MEKK3 in TNF induced NF-kappaB activation ... Using mitogen activated protein kinase kinase kinase 3 ( MEKK3 ) -deficient fibroblast cells, we found that MEKK3 plays a critical role in TNF induced NF-kappaB activation
Che et al., Circ Res 2002 : Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells : role of Gab1 and MEKK3 in TNF-alpha induced c-Jun and NF-kappaB activation and adhesion molecule expression ... Gab1 associated with MEKK3, and a catalytically inactive form of MEKK3 inhibited TNF-alpha induced c-Jun and NF-kappaB transcriptional activation, suggesting a critical role for Gab1 and MEKK3 in TNF-alpha signaling
Chiao et al., Cancer 2002 (Carcinoma, Hepatocellular...) : The current study data demonstrate that 1 ) RelA/NF-kappaB activity is activated constitutively in Hep3B cells, as determined by electrophoretic mobility shift assays ; 2 ) RelA/NF-kappaB reporter gene activity is inhibited specifically by dominant negative mutants of IkappaB(alpha), IKK1, IKK2, MEKK1, and MEKK3 and it is activated by overexpression of wild-type MEKK3, suggesting that upstream kinase cascades induce phosphorylation of IkappaB(alpha) and activate RelA/NF-kappaB in Hep3B cells ; 3 ) overexpression of the HBV x gene fails to activate NF-kappaB in HepG2 and Chang cell lines ; 4 ) The NF-kappaB-inducible gene, bcl-xl, is overexpressed in Hep3B cells and is inhibited by the proteosome inhibitor PS341, which prevents IkappaBalpha degradation and RelA/NF-kappaB activation ; and 5 ) inhibition of constitutive RelA/NF-kappaB activity by PS341 sensitizes Hep3B cells to doxorubicin induced apoptosis
Lerner-Marmarosh et al., Arterioscler Thromb Vasc Biol 2003 (Inflammation) : Because MEKK3 and Gab1 are critical for TNF-alpha induced c-Jun and NF-kappaB activation, we determined the role of SHP-2 phosphatase activity in MEKK3 signaling ... A catalytically inactive form of SHP-2 increased MEKK3/Gab1 interaction and inhibited MEKK3 ( but not MEKK1 ) -mediated c-Jun and NF-kappaB activation
Samanta et al., J Biol Chem 2004 (Breast Neoplasms...) : In this study, we established cell model systems to examine whether stable expression of MEKK3 could lead to increased NFkappaB activity and confer resistance to apoptosis ... Thus, our results established that elevated expression of MEKK3 appears to be a frequent occurrence in breast and ovarian cancers and that overexpression of MEKK3 in cells leads to increased NFkappaB activity and increased expression of cell survival factors and ultimately contributes to their resistance to apoptosis
Blonska et al., Mol Cell Biol 2004 : We found that TNF-alpha induced NF-kappaB activation was fully restored by MEKK3-DD in these cells
Fritz et al., J Biol Chem 2006 : MEKK3 dependent activation of an NF-kappaB reporter gene as well as ERK, JNK, and p38 MAP kinases correlated with a requirement for serine at position 526
Neumann et al., Biol Chem 2006 : Furthermore, we show that mitogen activated protein kinase kinase kinases ( MAP3K ), like TPL2 ( tumour progression locus 2 ) and transforming growth factor beta activated kinase 1 ( TAK1 ), have no impact on H. pylori induced activation of NF-kappaB
Qin et al., J Biol Chem 2006 : TLR8 mediated NF-kappaB and JNK activation are TAK1 independent and MEKK3 dependent
Gohda et al., Biochem Biophys Res Commun 2007 : These results strongly suggest that unlike cytokine signaling, Tax induced NFkappaB activation does not involve K63 polyubiquitination mediated MAP3K activation
Di et al., Cell Signal 2008 : However, the mechanism by which MEKK3 mediates NF-kappaB signaling is not fully understood ... Expression of non phosphorylated TAK1 interferes with MEKK3 phosphorylation and NF-kappaB reporter activity induced by transient MEKK3 expression or TNFalpha stimulation
Kim et al., J Endocrinol 2008 (Insulinoma) : Overexpression of MEKK3 , a possible mediator from the TNF-alpha receptor to the JNK/p38 and NK-kappaB signaling cascade, increased the levels of phospho-JNK, phospho-p38, and NF-kappaB , and reduced the glucose stimulated Ca(2) ( + ) influx and GSIS
Shinohara et al., Int Immunol 2009 : The serine/threonine kinase MEKK3 , also known as mitogen activated protein kinase kinase kinase 3, is a critical activator of the transcription factor NF-kappaB in innate immunity
Sun et al., Cell Signal 2009 : MEKK3 is required for lysophosphatidic acid induced NF-kappaB activation ... Together, our results provide the genetic evidence that MEKK3 but not TAK1 is required for LPA receptor mediated IKK-NF-kappaB activation
Samanta et al., Cancer 2009 (Cystadenocarcinoma, Serous...) : The authors have demonstrated that MEKK3 plays a critical role in cytokine mediated NFkappaB activation, and that stable expression of MEKK3 in cultured cells leads to increased NFkappaB activity
Sun et al., J Biol Chem 2010 : Here we report the identification of two regulatory phosphorylation sites at Thr-516 and Ser-520 within the kinase activation loop that is essential for MEKK3 mediated IkappaB kinase beta (IKKbeta)/NF-kappaB activation
Sun et al., J Biol Chem 2010 : Overexpression of PP2A catalytic subunit (PP2Ac) beta-isoform results in dephosphorylation of MEKK3 at Thr-516 and Ser-520 and termination of MEKK3 mediated NF-kappaB activation